<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17706

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPGEYLTNVLSSNCFSSIIYEYFEPQNLSLGTARKHLQRLEAGWRLEGKLVLCDPFKDGIWIFQGTPNTSNNTPAREADCSSIVEAFSAGLVQRDKGTYEPASLVKSKQAISNNTSTPSSSSSPSSSLDSTLRNAQALNSRSNSALGIMQEPPTPTPGARSAIGAETPTSLKDIHEYFISAVLGSIVYFLCRDYGFVPLNSRTLILTPLKPKFKGYSTNKHAHITNAIELATLDISLTSLGTLVVKAHSDLAPGLQPLFNTASSPGLPSKLVQGAALWLAPGGNAARFYSYTDDKNLSTNLSISQNQVGSADPRANCTNALIIKSWQSKYLEWLTTKGLNASALEDGGWLFVQVIGSHAPYFNAELQSLPIMEESAIVPWPALLCFQTSSPGLRYLEAVSNNPLGPRDSLSFAEEWFTGKDERASAISRRQKDRQAAEILSREQADVEARALQSINYSPATLRRGSNAGAMYPTPPDAPHHPIGATPSFDGNVSTPGNPHPFASHDPGPAIPLNPGANEGDADLWSLSNKKERNSSGMQFNDNENDSSNIYGDLGADIFVSDITDADFSFFDEPDAVQPDQKVDSPAAVSPPISQKPFSVAETAISNPANLQVFEPPDTTMLDLEIDQRDVDELPPHSLEKVVVKSNADSREARSSEMIDPDKQVRTSIDPPLDKETVFKHLLRDPSAKKSQRQPRRASLFHRVEFDDTLLSVNEKYGAHGYFNFSAKFKPKRVTKQSGLPQTQYLTSRRRMQENGEQFSNIARILNEKGLEAPTNSREPMDYLMDSDCASQASEQDDTSHPTDDLSLLPNVGVKRKWEKEEGDDMTSSFDALAMDLEHSTSTPQSISGSQIPLLEADPADWSLTTYFTSLEPDIQSNTLSDLERIATAQILADQAVSGTLRLPKAAGSETPFTSSTTFTTRELMSSVARAAKSCLIEVNSCTMRSYMEIQGIPAMNQGLRLPPRPNVNPRGQNSVDAARSNNPFSIPPPQLEVRRSDTKLSVLPAAITFWENLGLGPSKGPKDVSAICIYPNFEGVAANAESFLDQMRSIYECSRLGSHDRLVTKDLTNGLMPFTVESPQQSKLHHLSALKDVAARLSRMLSSATAEEKNFVVYFVYPTDNSALLVHICSAFQHLFNLYRKALSERRATISNELVLQLVPLDFISSSTSLAIPLPSEYFRLAMEVYDRCIDFVSSSSTAAIMLEQPLPKSIDFKLNSTPSASLLQENTCLHIAYAQSIDDRWITATWTDNRGTQQMTASYCLGRKNEPISMPFSDVAHEIWDTTLDYISNKKIHWRIMIARVGVMDPTEIDFWTGLASTESDAQVSLTLIAVQTDPSLRLLPASITLTPIANTTTSVATPVSTPQALQSSIVSPGDAATPARENASAATPVDGPAEPDSDARLIDSTDQSWGAILSHRLNNSNSLMELNPALISGYLIKRGGVNSDDPPIIMEVNILYSEVVGNPRTFHEGLLREILGYYRGLGTLARVRGLVDPVGDVRPWHIAAAEKAVKALYMLM
Length1520
PositionKinase
OrganismPezoloma ericae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha.
Aromaticity0.07
Grand average of hydropathy-0.335
Instability index43.49
Isoelectric point5.17
Molecular weight166158.59
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.09|      35|      94|     477|     519|       1
---------------------------------------------------------------------------
  477-  519 (49.55/39.94)	PDA..PHHPIGaTPSfdgNVSTPGNPHPFASHDpgPAIPlNPgAN
  575-  611 (60.54/24.86)	PDAvqPDQKVD.SPA...AVSPPISQKPFSVAE..TAIS.NP.AN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     272.73|      88|      94|    1104|    1196|       2
---------------------------------------------------------------------------
 1104- 1196 (133.79/90.16)	SSATAE...EKNF..VVYFVYPTDNSALLVHICSAFqHLfnLYRKALSER..RATISNELVLQLVPLDFISSSTSLAIPLPseYFRLAMEVYDRCIDFVS
 1197- 1291 (138.94/78.89)	SSSTAAimlEQPLpkSIDFKLNSTPSASLLQENTCL.HI..AYAQSIDDRwiTATWTDNRGTQQMTASYCLGRKNEPISMP..FSDVAHEIWDTTLDYIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.98|      13|      84|     333|     345|       3
---------------------------------------------------------------------------
  333-  345 (23.88/17.76)	EWLTTKGLNASAL
  416-  428 (25.10/19.11)	EWFTGKDERASAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     228.61|      61|     321|      94|     156|       9
---------------------------------------------------------------------------
   94-  156 (93.21/63.42)	QRDKGTyEPASLVKSKQAISNNTSTPSSSSSPSSSLDSTLRNAQALnSRSNSAL.........GIMQEPPTP
  430-  476 (80.17/45.65)	RRQKDR.QAAEILSREQADVEARALQSINYSP.....ATLR.......RGSNA..........GAMY..PTP
 1400- 1451 (55.23/28.57)	..................DSDARLIDSTDQSWGAILSHRLNNSNSL.MELNPALisgylikrgGVNSDDP.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.15|      14|      40|     688|     701|      10
---------------------------------------------------------------------------
  688-  701 (23.86/16.08)	SAK.KSQRQPRRASL
  727-  741 (19.28/11.45)	SAKfKPKRVTKQSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.97|      35|      40|    1012|    1049|      12
---------------------------------------------------------------------------
 1012- 1049 (50.30/42.96)	WENLGLGPSKG..PKDVSAiCIYPnFEgVAANAESFLDQM
 1053- 1089 (58.67/35.24)	YECSRLGSHDRlvTKDLTN.GLMP.FT.VESPQQSKLHHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.77|      28|     124|     241|     268|      14
---------------------------------------------------------------------------
  241-  268 (48.75/26.93)	LGTLVVKAHSDLAPGLQPLFNTASSPGL
  367-  394 (52.02/29.24)	LQSLPIMEESAIVPWPALLCFQTSSPGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.77|      14|      17|    1325|    1339|      15
---------------------------------------------------------------------------
 1325- 1339 (19.72/14.16)	AQVSLTLIAvQTDPS
 1345- 1358 (24.05/12.86)	ASITLTPIA.NTTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.30|      10|      15|     981|     990|      18
---------------------------------------------------------------------------
  981-  990 (20.15/11.90)	RSNNPFSIPP
  997- 1006 (17.15/ 8.84)	RSDTKLSVLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.55|      14|      17|    1365|    1378|      19
---------------------------------------------------------------------------
 1365- 1378 (24.55/14.81)	TPQALQSSIVSPGD
 1381- 1394 (24.00/14.29)	TPARENASAATPVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17706 with Med13 domain of Kingdom Fungi
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