<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17696

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMENGRNGSHTNHDRDQRPNGINGANHVPEKNQEKGKGKAEPQQNMTPISPTISNGLNGNFMDGQRHQNGGTDAVSENLQERLNQLPPEIVHITQGYMPLSKLLSRLAQKTHSDLSSTILELAQMPIPASALNGNSSHVTTVDDNSPENLAKKLRMLKFAQDAHTEWTKALVITGWSRRAEDVSRTIDLKIHLDNQMGFYDSAFSELAEVKRGLIHARLPNPDLRTALEVLTTGKASWMPDLGYIQPPPLTAKEILKSLENLNTLLTIRLNLHDYNSIPLQFKDFAIKSGRVTFKVAGEFEIDLTIADEDPETQFWFIDFRFMFWPSVSTLAPQLRFHIESKVNEALAKDGLAGCYKYLHEMVLTHKISQFRKQAMDLARAKWIDTLKVEALNRALSIQYWLDRYGAKGPRSWIILGVHSGKRKDGRPDPKATSRLFIRWFRDSKEVPDIDVHFDTVNINTQSLLKTVIAKHVSHALTSIHDNLAAQPLFANRELALSLSISLTEPAESALKVQLTSEQYLTVKIEPISGRFVFSPASRLTAEWENRLNLQTMNPANDGHTYIERLRTQLLAEEIISRGQSVGWMVIRNPGLKADVLQPYFPRNTQPQTLWFRRPGWLDDWCVAVIMSPGGEQWLLFETADAPTTLSSSNITPSRRITSSIKIPSKLASPVPTYEFLSTLNIFAAALVSHYCNLRALHGKRAVHILRKGRPSKAVTLPSIYVRLSELLVSKGKSARTGNPWAKDVIRLTFQGLELVPQKSADANAPIPENQAQAPGDLVSRRPTPQETAVMISEARMIVSQSSEASVLVNINEKVDKDIAFDPNSGSFAFRLRSQVGGSVIPDLVERLVRVERLVEFVQVLQKHEKTLKCETVSLGKIVFTYGNASASREFDGMDLDTTSHPYKATVDFSAMENNMTLVLERENPHLRIADYLAKVLNGPEGLDGVATFLPLTLPVLRGLDAMESAWTLAPDTEKGELFINVRAMDWYMIRYNVKQPSPTADSPPTLRKIMFEVRLRHRRGDPWWYVRRSDTITRSSKETDDIDDALKAVWNSKGSGWQGMRVSGVAQVSGVEELLGKLDEVMRNLPVASS
Length1095
PositionTail
OrganismPezoloma ericae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha.
Aromaticity0.07
Grand average of hydropathy-0.343
Instability index41.92
Isoelectric point8.78
Molecular weight122664.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17696
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.25|      34|      36|      24|      57|       1
---------------------------------------------------------------------------
   24-   57 (60.46/39.38)	NGINGANHVPEKNQEKGKGKAEP..QQNMTPISPTI
   59-   94 (55.80/35.75)	NGLNGNFMDGQRHQNGGTDAVSEnlQERLNQLPPEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.41|      24|      36|     588|     614|       2
---------------------------------------------------------------------------
  588-  614 (41.02/33.69)	W..MVIRNPGLKADVLqpyFPRNTQPQTL
  625-  650 (41.38/24.50)	WcvAVIMSPGGEQWLL...FETADAPTTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.50|      21|      35|     975|     995|       3
---------------------------------------------------------------------------
  975-  995 (39.85/25.81)	PDTEKGELF.INVRAMD....WYMIR
 1008- 1033 (30.65/18.14)	PPTLRKIMFeVRLRHRRgdpwWYVRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.14|      14|      28|     688|     701|       4
---------------------------------------------------------------------------
  688-  701 (24.71/15.89)	AAALVSHYCNLRAL
  718-  731 (23.43/14.72)	AVTLPSIYVRLSEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.99|      27|      28|     235|     262|       6
---------------------------------------------------------------------------
  235-  262 (44.39/28.70)	LTTGKASWMPDLGYiQPPPLTAKEI.LKS
  266-  293 (41.60/22.50)	LNTLLTIRLNLHDY.NSIPLQFKDFaIKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.64|      63|     590|     294|     387|       7
---------------------------------------------------------------------------
  320-  387 (101.73/108.38)	WF........IDFRFMFwPSVSTLAPQLRFHIESKVNEAL.A..KDGLAGCYKYLH.EMVLTHKISqFRK.QAMDLArakW
  444-  506 (61.96/23.32)	WFrdskevpdIDVHFDT.VNINTQS.LLKTVIAKHVSHAL.TsiHDNLAAQPLFANrELALSLSIS...............
  929-  971 (51.95/20.13)	.........................PHLR..IADYLAKVLnG..PEGLDGVATFLP....LTLPV..LRGlDAMESA...W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.16|      36|     358|     526|     566|       8
---------------------------------------------------------------------------
  526-  566 (58.34/43.57)	TVKIEPIS.GRFVFSPASRLTAEWENRLNLQTMNpandgHTY
  871-  907 (59.82/33.56)	TLKCETVSlGKIVFTYGNASASREFDGMDLDTTS.....HPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17696 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMENGRNGSHTNHDRDQRPNGINGANHVPEKNQEKGKGKAEPQQNMTPISPTISNGLNGNFMDGQRHQNGGTDAVSENLQERLNQLPPEIV
1
95










Molecular Recognition Features






MoRF SequenceStartStop




1) GDPWWYVRR
2) IMFEVRL
3) RLFIRWF
1025
1014
439
1033
1020
445