<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17693

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSLQTWQHFLARSLATRLEPSDFESYVQLLSAKHPLPASRISDLFLQPTEYNDASLDPRVVRYVQVLVHLGLVTVPSVLRAMWKCSSFRDQDGGGARSAPLVDNNSGNGEAEKLGKMEEGKRWSNSYIAEETLFYRLTKYISSGAAPRDTQEAVELVLSCVQWMRTVVSVQQAAQEMLGLAQTHTAEMNAQNMALGTLIVAAVESGRVLHALGKGNVPKHVRKELKDTLASFVPLLLQSSPQSAGRLEVFRTQTMLAIEPVDKKEKAAAKEIEDILEEGMALGVESMVVAEMPTMNSRAGLYVYLNSLLVGRPLIDDHAIFAYLHNRYQGDIQSTIIDLILAAFDVLANATFRNERAQSITILRSFLINKIPPLLATLSASLFPPLTSEYCITEALNHVDTNAFPTLSGMFDESSTNDMFSDSVRQDFCFACCLHGLIEESSIETLLGDLPIQSLPAGGRYLKDDLVQQCLTDPARTEGLIDELEHMDGNVGAVSQAITEVVRRLCANKETMSLKSLCSQLARKPSSLDVMLLFDKPISILQPLCELLDNWRYDEDQGEYQPVYEEFGLILLLVLSFAQRYGLSVVDLGIRTPDSFVAKLLNQGHLSRAMDDLTEQEQSHLDGWIRGLFETGTLGDELMSSCPPQDFYLLVPTLFHHIVLACSTKNLTDEGLKSGLEYLVEPFLIPSLIPGITWLSSHLWESRGDANACVAILTALITNSSNNTEASQMLTAILNIVAKNLEHSLRWLQRAEPSRQDVEPLSKALRPSLGWERRGASDHTELESWTSSPGGGLVISIKNTIANLVQWGLNPGININPANYTHRQILVGVKMLGAKRILTAIIEEVKSQTENGNGSVVLDIATALICAPDPQSWDNGVPGIGIDGLGAEIRPLQRRMTLREALKNEAEAAPKAQKTDAFHAETVVRLFRKVEAQAQMPQQALMSHEALNIHQALDEAALDGAMAGVGSLDGMGGTDMLGDGMGGDDLMNDLMGTGGGDLFGNGELGDGMGF
Length1011
PositionTail
OrganismPezoloma ericae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha.
Aromaticity0.06
Grand average of hydropathy-0.068
Instability index47.99
Isoelectric point4.91
Molecular weight110565.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17693
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.81|      10|      65|     808|     817|       1
---------------------------------------------------------------------------
  786-  799 (14.52/ 6.19)	WTSSPGgglvISIK
  808-  817 (21.29/12.55)	WGLNPG....ININ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.49|      29|      86|     859|     887|       2
---------------------------------------------------------------------------
  838-  857 (19.28/ 6.71)	..ILTAIIEEVKSQT.ENGNGSV.......
  859-  887 (55.50/32.11)	LDIATALICAPDPQSWDNGVPGIG.IDGLG
  948-  973 (38.71/20.34)	LNIHQAL....DEAALDGAMAGVGsLDGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.02|      43|      86|     360|     403|       3
---------------------------------------------------------------------------
  360-  395 (53.93/29.10)	..............................................SI.T.ILRSFLINKIPP....LLATL.SASLFPPLTSEYCITE
  397-  484 (38.33/19.89)	LNHVDTNafptlsgmfdesstndmfsdsvrqdfcfacclhglieesSIeT.LLGDLPIQSLPAggryLKDDLvQQCLTDPARTEGLIDE
  485-  522 (31.76/11.50)	LEHMDGN.................................vgavsqAI.TeVVRRLCANKETM....SLKSL.CSQL............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.48|      29|      68|     667|     705|       4
---------------------------------------------------------------------------
  667-  705 (45.85/47.70)	NLTDEGLKSGLEYL..VEPF..........LIPSLIpgitwlsshlWESRG
  736-  776 (42.64/24.03)	NIVAKNLEHSLRWLqrAEPSrqdveplskaLRPSLG..........WERRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.08|      24|     145|      66|      89|       5
---------------------------------------------------------------------------
   66-   89 (43.38/29.40)	QVLVHLGLVTVPSVLRAMWK..CSSF
  208-  233 (35.70/22.88)	RVLHALGKGNVPKHVRKELKdtLASF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.93|      14|      25|     974|     987|       7
---------------------------------------------------------------------------
  974-  987 (26.88/12.81)	GTDMLGDGMGGDDL
  996- 1009 (28.06/13.67)	GGDLFGNGELGDGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.56|      13|      25|     595|     607|       8
---------------------------------------------------------------------------
  595-  607 (22.20/14.85)	DSFVAKLLNQGHL
  623-  635 (24.35/17.07)	DGWIRGLFETGTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17693 with Med5 domain of Kingdom Fungi
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