<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17689

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNTMGSLPSDFAISLKAQPSSKTNANLPSLIERINIERGGFQTITEESLRQEIAEAELDNEDGDEDDTSDEEEEELDRMKELMTSREEMLGQIETAHQSAMFALDFVSLLLSKDTPVQASLSISPALRELVGMGTLGADKLHAPRITDAQKQDNKQIAKGWKSQSLNKTVDSILASASRLEKEIELETKYWQQVLAVSESGWSVCRLPNEKHTLGVRFGFSEASPAFKNRSLAALRRNPDGSISLDQGIVSSEPQILRVRIQSGNKQTGSSAVPQPAAENAPVEALILQARNTIFAEELWQELNREARSLGSYGVQSKDDTLVCPLSATKTAVFDLVPLGEASLTGPDDSMAEGVFISLNLLLSYAHRQNHRRRTQPPPPISSQKKIIQPYNLLRFLLTRLKHQETIGQLNHLLGSLCRVIELAQVKPLPSFKVTFTPWTPPSHISQAERTMLSLIDRLEGIATFSITETTTITITARTTIFPIGSTFALSLSPGSPLMSICPPHPVLTSYPALRDYIHYFTACTIATSISSVGGSGIDDINDGGQAVWHQTPHPTTLRTLLAPSVTGSKLPRTKQLSLSIQPLSTEPKTGVRMRAHWEWNGPEQPEHGSIGRRASFEATPLQKEDIQMALELEKEKKEKEEAEGEEGEKMRRVKGKGEGVYDWVMWETEDGKGWDEGEGEVFRSLESVVTDAGK
Length695
PositionHead
OrganismPezoloma ericae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Hyaloscyphaceae> Hyaloscypha.
Aromaticity0.05
Grand average of hydropathy-0.425
Instability index54.80
Isoelectric point5.30
Molecular weight76637.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17689
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.35|      46|      53|     261|     313|       1
---------------------------------------------------------------------------
  261-  313 (67.00/56.33)	IQSgnkQTGSSAVPQPAAENA.....PVEALILQARNTIFAEELWQELNrearSLGSY
  315-  365 (71.35/42.98)	VQS...KDDTLVCPLSATKTAvfdlvPLGEASLTGPDDSMAEGVFISLN....LLLSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.41|      37|     420|       7|      46|       2
---------------------------------------------------------------------------
    7-   43 (64.90/33.59)	LPSDFAISLK..AQPS..S...KTNANLPSLIERINIERGGFQT
  429-  464 (43.94/19.31)	LPS.FKVTFTpwTPPShiS...QAERTMLSLIDRLE....GIAT
  571-  602 (42.58/18.38)	LPRTKQLSLS..IQPL..StepKTGVRM.....RAHWEWNG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.61|      34|      48|     471|     506|       3
---------------------------------------------------------------------------
  471-  506 (57.76/43.39)	TTITITarTTIFPIGSTFALSLSPGSPLMSICPPHP
  522-  555 (62.84/41.01)	TACTIA..TSISSVGGSGIDDINDGGQAVWHQTPHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.97|      24|     561|      50|      80|       5
---------------------------------------------------------------------------
   57-   80 (40.39/32.73)	ELDNEDGDEDDTSDEEEEELDRMK
  632-  655 (38.58/17.26)	ELEKEKKEKEEAEGEEGEKMRRVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17689 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TEESLRQEIAEAELDNEDGDEDDTSDEEEEELDRMKELMTSREEMLG
2) TGVRMRAHWEWNGPEQPEHGSIGRRASFEATPLQKEDIQMALELEKEKKEKEEAEGEEGEKMRRVK
45
590
91
655










Molecular Recognition Features






MoRF SequenceStartStop




1) EGEVFRSL
2) GVYDWVMWETEDGK
3) KMRRVK
679
660
650
686
673
655