<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17579

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDSFSLPLRPRLDRPDPPDPLPLEIAQINAQWGSFRHVSEDFLRHRIADQSDDASEDHDESPTEVDTTERLDQLYRKRAEITQFAHQAHMEALFALDFVSLLISHHAPRQAETSMSAYLKQVAPMGSLTPEVVDPPPKPDAVRRDTAAVARGWRLQNFHSAANKLLTAATRLESEVAAETRYWNEVLSIQHQGWKVCRLPRDRQALGVQYGFLEATPIFRDRGLASLRRADDGSLLLDQGLVPQKARRVRVRVKTAGRWTGASRTPPPSTSDPDAIEARIRQARDTVYEEELFHEMMREARILAPHGVTTRQNLVRVPVSDEQEIWLDLVDTDGEAPPPPADDGPPAPADDDRLADALAHALRILLTHAHRQNRHRREQPPPPLTPRRRHTPEYHLLRPLLAGLQHRAHVRALEAVLRDLHRVRRAAGLAGDGTVTPFASVRPPAPHPGLPTVESLVRSLLRPLESTLGGPLAAPQASVHVTVRTAITGPPGGTVFDLAVHLPAFPDVQPPARIALRSEVEAVLSHVLLLDVVAAVAAAPATAPGRRWEPAAPHHGELVTAGGSSAAQNRKLTIHLSRDGLRVEAVAVGGLDPFGRPMPDPTATPSSRTWTAESTGPGLLEFVGEVSRE
Length630
PositionHead
OrganismAspergillus taichungensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.05
Grand average of hydropathy-0.417
Instability index50.88
Isoelectric point6.54
Molecular weight69166.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17579
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.44|      30|      34|     361|     390|       1
---------------------------------------------------------------------------
  248-  282 (35.88/13.55)	R.....RVRVRVKTAGRWTGAS..............RTPPPstsDPdaIEARIR
  283-  312 (25.24/ 7.23)	QardtvYEEELF...HEMMREA..............RILAP...HG..VTTR..
  361-  390 (55.92/25.45)	H.....ALRILLTHAHRQNRHR..............REQPP...PP..LTPRRR
  407-  452 (26.40/ 7.92)	HrahvrALEAVLRDLHRVRRAAglagdgtvtpfasvRPPAP...HP..GLP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.15|      47|      62|     514|     566|       2
---------------------------------------------------------------------------
  514-  566 (69.65/49.11)	RIALRseVEAVlsHVLLLDVVAAVAAAP.ATAPGRRW..EPAAPHHGELVtaGGSS
  579-  628 (79.51/40.51)	RDGLR..VEAV..AVGGLDPFGRPMPDPtATPSSRTWtaESTGPGLLEFV..GEVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.65|      31|     120|     199|     233|       4
---------------------------------------------------------------------------
  199-  233 (47.04/27.94)	RLP.RDRQALGVQY....GflEATPIFRDRGLASlrRADD
  317-  352 (51.61/21.27)	RVPvSDEQEIWLDLvdtdG..EAPPPPADDGPPA..PADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.19|      20|     120|      19|      57|       6
---------------------------------------------------------------------------
    2-   26 (28.57/28.09)	SDSFslpLRPRL.DRPD....ppDPLPLEI
   40-   66 (26.62/12.42)	SEDF...LRHRIaDQSDdasedhDESPTEV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17579 with Med17 domain of Kingdom Fungi
Unable to open file!