<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17570

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPTAGVPSWGPPPRAFNPSGARRPPDLSQSQAYAVPQSEMSTSMPQPLPRQPAVIDLTANVGDTQEREPPAKRPRLDLPVAASSVGDRSPVPGSGGEARITPGVGSAKPPSFALRGRPVWSFQALVSEAPGAGEVREGDAVAVAQRGKRAEPPPFPVLPWKAPPPSSLETSGAKSRDSSPSKVVQTTPYHIEVPPSAPVLKGDRIADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLHMLSSVFTAALEKRQNHNTVANPSTFKPPPRVTLTDNKREVWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLSKWIPVSRAVWLAKCVGANEIRAFKRKGTSGTLAVGLEAKWVREWTATVQQFLEGVIAACGSADWRRKMTYAVSLTARLFFERLLDHDQYLGWFLTSLEVAPLNTVPAWLLMLGIYWDSILRYRKRARRLSESLLAKLHPISKLDPTAPLRPLADRLSFFVKRLILEHTSSVVLLDSWDKYKDLISSCLDFNDNVHQAKFQNLAERNLRIQSPKSQQGLGQQSPQQRLIHLLDSINATHDISATSAACLNAIDDRGIVVSKLLEWTATSFRYGICRVYIAVRLLRKWKASGVDIDSHILDFLNGERNTDSLNMGNVYHVISELVRSQTFSVGRYLQWLMAKGVAADGSGSGQPQQSEALGLLLQLPTGRLPEHVRNLRNTLLTRAGISASQEESTIASLKVSVAEQLPEVFEIQMLGVAMADISPNDLTWAVKSEIGQWMRRGVTGYARESHLKIPGASWASEARVCALSPDQFYRVRSILESFEDLSMLADVLKQASNSQDSVVLASAADTVSYHFSSFSAIGAVADLFKGLVESYSCLKRLGPPNLDLVFSLIELGLQMPNELNTVALLRQDLCRIENRSALTAPSPLSDHAPLAFNPMDSAIHEKLDQLLGSNGGIDESTMDTIFSSLTKILGSVDGQPRLSANDTCRYLAQLRLFRPKHFDGMLVRWICSLLRSPARPALSQILPPLIGVGCVTIQAFVFLVKRILQSEKVSTAFPNLADLRIDLLELLIPSDSFEPSNHPDLVTYRFHLAQREFIAKHPRETFDIVRDAISLVNTHHGQVNPRRADLTSCAMSLVHVLLTQDPERAVKYCMEKFVDHSSSTGVLQQALDHLLGFDSGPERPAEKVVDMNDDFSLPFCQLKLQMMFNAEPGNSANNGIVDAMFSAAVADSRANRTHWVGLVSLMSLDAVRQIRERAEKAFFSISMFEDPTHDSTTDRASSPDIAKLYLTIIEKLAFSVPETGVPSVAPILVEKMDLLLHRLVVMQSNFLGSAANKQGGGSEQMVRARANFERTLAFWFSALLKIVVIHRSSFVTSSLTARPTISQEQSRLLISIFCISLARLPDHVLRLFPAADYFPHPVLSETHRPCPGILLQTHALDVAASLIDMFPDEARQHCARFLKEKCPPFIQVQANPRVPYLLGPVPDVAANAPQPASLPSPSPVAGGSTPTPIPSGNFTPGPAAPQQHIPAANIAPGLSEGTDYIAGQLRLQCRGRVVGPYPVRPWELLEDAAPIVGVNDTAINLKYFDARRVRA
Length1591
PositionKinase
OrganismAspergillus taichungensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.153
Instability index50.55
Isoelectric point8.77
Molecular weight174930.25
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17570
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.57|      33|      42|      50|      86|       1
---------------------------------------------------------------------------
   50-   86 (49.38/35.19)	PLPRQPAVIDLTANVGDTQEREP....P..AKRPRldlPVaAS
   93-  124 (49.72/25.37)	PVPGSGGEARITPGVGSAK...P....PsfALRGR...PV.WS
  136-  166 (33.48/13.26)	GEVREGDAVAV.AQRGKRAEPPPfpvlP..WKAP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     224.46|      59|     172|     880|     939|       3
---------------------------------------------------------------------------
  880-  939 (98.40/53.71)	PNL...DLVFSLIELGL.....QMP.NELNTVaLLRQ..DLCRIENRSALTAPSPLSDHAPLAFNPMDSAI
  976- 1023 (56.81/25.85)	PRLsanDTCRYLAQLRL.....FRP.KHFDGM.LVRWicSLLRSPARPALSQILP................
 1054- 1109 (69.25/33.15)	PNL..aDLRIDLLEL.LipsdsFEPsNHPDLV............TYRFHLAQREFIAKHPRETFDIVRDAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.49|      22|     258|     942|     963|       9
---------------------------------------------------------------------------
  942-  963 (36.76/21.87)	KLDQLLGSNGG..IDEST......MDTIFS
 1169- 1192 (20.96/ 9.28)	...HLLGFDSG..PERP.aekvvdMNDDFS
 1199- 1222 (31.77/17.89)	KLQMMFNAEPGnsANNGI......VDAMFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.71|      35|      40|     336|     374|      10
---------------------------------------------------------------------------
  336-  374 (51.05/42.55)	KWIPVSRAvWLAKCVGANEIRAFKRKgtsGTLAVGLEAK
  378-  412 (61.66/38.11)	EWTATVQQ.FLEGVIAACGSADWRRK...MTYAVSLTAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.02|      28|      99|     473|     503|      11
---------------------------------------------------------------------------
  473-  503 (37.36/38.67)	HPISKLDpTAPLRPLADRlSFFVKRLiLEHT
  573-  600 (49.66/33.04)	HDISATS.AACLNAIDDR.GIVVSKL.LEWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.16|      24|      99|     662|     690|      12
---------------------------------------------------------------------------
  616-  644 (36.01/20.22)	RLLRKWKASGVDIDSHildflNGERNTDS
  667-  690 (43.15/22.29)	RYLQWLMAKGVAADGS.....GSGQPQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.72|      15|      41|    1315|    1329|      13
---------------------------------------------------------------------------
 1315- 1329 (26.08/21.19)	LLHRLVVMQSNFLGS
 1359- 1373 (24.64/19.52)	LLKIVVIHRSSFVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.54|      14|      15|     730|     743|      15
---------------------------------------------------------------------------
  730-  743 (22.00/13.48)	IASLKVSVAEQLPE
  747-  760 (24.54/15.92)	IQMLGVAMADISPN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17570 with Med12 domain of Kingdom Fungi
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