<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17569

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPGGSITNIRAIDGFSSIYWRIYTEEPNIASIPGETPANGYTILRHLSRLKDLELRLRNADCLVSSYPRRLGLWVFSATPDFESLDPLCPNKGQDERSRLVVDSFTLKASGLGSTTAADLIKNLSTEPQTPGQNAPASQRPPNGPPPARRMDGYASPGAIYAAFISAVTGALSLQLIRRDHAIPLGSRTLFTAVERDDHECPRIANDDPASIPTLTTLHVQLTSVGKLMISLPTVAQDGITRLSQPDSAPEDIVDAPRGTDLWLSPSGSVARLVSGNPDSATAPSPYVLADATGNDRSRSVHHKQWKLAVLDWLKCFGLPVRPIDEMTWVEIEVWEPFYSRLAGETWRVGEDNTPTLPLKRILWPAIYCFRRTRAAVSTLVNPLCSSPSLHNDPLGFAEMWRTVEIPKPVERDPMPLASHQDEQPKAETDSGELDLPEGIESLSRASQYPELQTASLVYPTPPDGAASLGVHPTNTTDFFVEDSSFGSLPSQTKVGSLAQIPTGDSDVPMVFGPAAGLVVGSGLYDTNDDDLFGDMDEQNFGDKGITDADFNFFDDADFQGLGDGPPGQGTDEMADLLGAEPDASPAVSMQPPLETEQPSDRQDPVEHIEAPQFSSTDQQVKLEEEQIGPRDNTTPPSSQNDNNQTISPPLSPVEVKKIILPAPDGNGQLPVPKGQKSYYKPVAFKQDMSNWDQKYGAAGKFWFTNAPSGPGKSSKADGDIPTIGLPRHTRNSVASRDVAKTMDGHGSPSTEMAQDDQSSVTSEGSDESASDSESSHVTLPTLKRKRVRSNSPSTPAMSHGIAPTEDEQDSQGYRAEDAVFLGNLLSTFSDWSMTGYFSFPDNRVLPAIARREVQVQIAQLLSDQVTQTSLDHKLDGDLGLGDFGSKLYSLRTSLEDTPFVGGSERLDLSNFASLQDNNNLFSPPSGGLTPRQSSQRREAGRGSVSKLPSPHLRVRRGKDYLEVLPAAISFWETFGLEPAHGPKNITAYCIHPHTAGDAADVFLERLSLAYASCNLGTHSRGNESSFFEHGLGKWVTTVTEGIGYPNVMLSLRTMCEEFGAVLTQGMPKEGNIVLYIVNPFTHATALADICAAFWSLFQKYSADADTQQTRQLNELVLQIVPSDFVMSAESLVVPPQTRYLSLALEVYSRCHPKPPSTSLAGCAPPVLLADSIPRSINFRLAPEKSSPLQDGRCLHIACSRSQDQRWLSVAWSDTSGNLQRSISYCLRFRNASAYTAMSDIRGEIWKATKEMLDQAQARWRIMLAYTDTVDQEEIDTWSNFIDQYSKTNAVSLELTIFAINTTSDLSLEPPATPIPMSVFSSQTASTPVATPNPSGSVLSPEQSANAPTPPSGGGAAANAPTPTDAQIEAESEATLTDVCDETWSVILSHRLNNSPHLTELRPVLASGYLLRRRGAADGDGVYSMCVNLIHTTRPTQSYEGILRETLGMYRGLATLARTRGTITVQHSTLPWHVATAVRAQEVLSYVL
Length1490
PositionKinase
OrganismAspergillus taichungensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.381
Instability index51.15
Isoelectric point4.92
Molecular weight161883.86
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17569
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.38|      12|      15|     749|     763|       1
---------------------------------------------------------------------------
  749-  762 (18.58/10.58)	GspSTEMAQDDQSS
  767-  778 (20.81/ 6.33)	G..SDESASDSESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     735.50|     174|     287|     511|     686|       2
---------------------------------------------------------------------------
   78-  235 (127.64/59.34)	..........................F.SATPDFESLDPLCPNKGQD.......ERSRLvvdsftLKASGlGSTTAADLIK.NLSTE.P...QTPGQNAPASQ.................RpPNGP...............PPA.......RRM.............DGYA...........SPGAIYAAFISAVTGalSLQLirrdhAIPLGSRTLFTAVE...........................rddhecPRIANddPASiptlttlhvQ....LTSVGKLmisLP
  236-  368 (128.17/60.05)	TVAQD.............GIT..RLSQ.PDSAP.EDIVDAP..RGTDlwlspsgSVARL......VSGNP.DSATAPS..PyVLADATGNDRSRSVHH.KQWKLAVLD.WLKCFGLPVRPI.DEMTwveievwepfysrlaGET.......WRV...........geDNTPTL....P...L.....KRILWPA.................................................................................................
  370-  528 (144.97/68.56)	........................YCFrRTRAAVSTLVN.PLCSSPS.......LHNDP......LG.FA.E......MWR.TVEIPKPVER.DPM.....PLASHQDEQPKAETDS.GEL.D..L...............PEGieslsraSQY.............PELQTASlvYP..............TPPDG..AASL.....GV........HPTNttdffvedssfgslpsqtkvgslaqiptgdsdvPMVFG..PAA.........G....LVVGSGL...YD
  529-  715 (292.34/151.79)	TNDDDLFGDMDEQNFGDKGITdaDFNF.FDDADFQGLGDGPPGQGTD.......EMADL......LGAEP.DASPAVSMQP.PLETEQPSDRQDPVEHIEAPQFSSTDQQVKLEEEQIGPR.DNTT...............PPS.......SQN.............DNNQTIS..PP...LSPVEVKKIILPAPDG..NGQL.....PVPKGQKSYYKPVA.........................fkqdmsnwDQKYG...AA.........GkfwfTNAPSGP...GK
  872-  933 (42.38/14.43)	SLDHKLDGDLGLGDFGSKL.....YSL.RT.....SLEDTPFVGG.............................................................................................................serldlsnfaslqDNNNLFS..PPsggLTP...........................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.19|      10|     287|    1086|    1098|       4
---------------------------------------------------------------------------
 1089- 1098 (20.70/16.05)	LADICAAFWS
 1378- 1387 (20.49/ 6.66)	LTDVCDETWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.68|      16|      22|     990|    1005|       5
---------------------------------------------------------------------------
  990- 1005 (31.66/19.02)	AY..C.IHPHTAGDAADVF
 1012- 1030 (22.02/10.89)	AYasCnLGTHSRGNESSFF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17569 with Med13 domain of Kingdom Fungi
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