<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17559

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNVSAGGIKPRVDVQDSRNGITHPPGSTGNIQNGSFHVNGGMDDQGHKAAVIPAVSAQNPPELLHITQGFFPFSTLINRSVQQCWNDLSELITELAEVQIPSQGSGSPTSNLNGKPPGNQSPENLQKKLRVLNFAHAKRAEFIKLLVLSRWSRQAVDVSKLIDLQNFIRIRHQAYVGALQSIGDMKRDLVQAQVANPDLQTALEVLSKGQVVSMSDLGYKPPRPLTAKGALKRLKKINRIISVRLALHDAVPPSLKTYHVHDGRVTFSVPGEFELDLSIGEENELSQFYFVDVRFLFTPSSPIPSGRVFNELDLRINDILRNDGLAGCFHFLHSLVLTNKVNILFKQAIQLARGLWTDILHVELLHRTLVVQYWALKPGPKSWLEIGVKCGRRKTEGQGPGLPYLGLRWLRDGQEAGSEEIHFDAANLSMEHILRSAIALHISHILSSAYNRIIKASLYAAGALSLRAQIDGTEPGDCQLDVQLTTSRRARVSIEPMSGTIILSTTPNASERPDSDRSSDRTPVDDIVSRVSRLRCVSAIEQIESSVKMFGFQPVSPRGLMIDFRKIFPPNVLKFSFFSHRLWKRDWMIAATSSVDGDSWWIVHVQSASSSRHQSVLSTDIYSPSTLHSAQPVSNSLFPVEYGTSYASLADLGHCLSGILAVYANAVCLAGFQGITFYPHLHRLRIGSDLKVPDIFVKYDTSNIPCGLQISLPSWFKKRDFINDTIRIAFHGIDSRKKVAIMVAYGTLSNPVKVSGTLPSKWDHSVTFQKKGNGFAIRLLAPVGSPVILELFESLQRLECVLSMIDTLQAKKMELRKLSLSGISFAYGPGKNLAANIEMGTSRARAEAPCQLRLNIQLPFPNLHRRIQAPLADMLNRASTADAGLDSVSDLLSLTLPLMLALDQITANPSRKDTMKVQVIVRNARNYRIHYPGHQCRFQLLAGQYLGRMAWILKDAGGRQGGDHQEQLRTRLRSELYDSKGEGWKGLGNGAVSDFDKVGNLITQLDKIFHTNQNDLGAATSSGPGGELKNHKDPILPVAAGQPNGNNGLISPARPDGNATTTTGHSVKASGAAQNADFIMID
Length1088
PositionTail
OrganismAspergillus taichungensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.182
Instability index45.31
Isoelectric point9.33
Molecular weight119526.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17559
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     677.16|     238|     376|     253|     539|       1
---------------------------------------------------------------------------
  253-  539 (334.67/349.11)	LHDAVPPSLKTYHVHDGRVTFSVP..GEFeldLSigeenELSQFY........FVDVRFLftPSspIPSGRVFNelDLRINDI.LRND.GLAGCfHFLHSLvltnkvNILFKQ......AIQLA.RGlwtdilhVELLHR.TLVVQYWALKPG.......PKSWlEIGVKCgRRKTEG.....QGP.GLPYLgLRWLRDGQEAGSEEIHFDAANL.SMEhiLRSaiaLHISHIlSSAYnriikaslyAAGAlSLRAQID.GT......EPgdCQ..LDVQLTTSRRARVSIEPMSGTIILSTTPNASERPDSDRSSDRTP....VDDIVSRVSR
  633-  917 (342.49/230.36)	LHSAQPVSNSLFPVEYGTSYASLAdlGHC...LS.....GILAVYanavclagFQGITFY..PH..LHRLRIGS..DLKVPDIfVKYDtSNIPC.GLQISL......PSWFKKrdfindTIRIAfHG.......IDSRKKvAIMVAYGTLSNPvkvsgtlPSKW.DHSVTF.QKKGNGfairlLAPvGSPVI.LELFESLQRLECVLSMIDTLQAkKME..LRK...LSLSGI.SFAY.........GPGK.NLAANIEmGTsraraeAP..CQlrLNIQLPFPNLHRRIQAPLADMLNRASTADAGLDSVSDLLSLTLPlmlaLDQITANPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     284.35|     105|     908|      14|     126|       2
---------------------------------------------------------------------------
   14-   69 (66.89/34.37)	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IKPRVDVQ.DSRNGITHPPGSTGNIQ..NGSF..HVNGGMDDQGHKAAviPAVSAQNPPEL
   70-  126 (47.34/37.64)	LHITQGfFPFSTLINRSVQQcWNDLSELITELAEVQIPSQGS.GSPTSnlNGkpPGNQ.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  921-  978 (60.12/25.97)	..........................................................spenlqkklrvlnfahakraefikllvlsrwsrqavdvsklidlqnfirirhqayvgalqsigdmkrdlvqaqvanpdlqtalevlskgqvvsmsdlgykpprpltakgalkrlkkinriisvrlalhdavppslktyhvhdgrvtfsvpgefeldlsigeenelsqfyfvdvrflftpsspipsgrvfneldlrindilrndglagcfhflhslvltnkvnilfkqaiqlarglwtdilhvellhrtlvvqywalkpgpkswleigvkcgrrktegqgpglpylglrwlrdgqeagseeihfdaanlsmehilrsaialhishilssaynriikaslyaagalslraqidgtepgdcqldvqlttsrrarvsiepmsgtiilsttpnaserpdsdrssdrtpvddivsrvsrlrcvsaieqiessvkmfgfqpvsprglmidfrkifppnvlkfsffshrlwkrdwmiaatssvdgdswwivhvqsasssrhqsvlstdiyspstlhsaqpvsnslfpveygtsyasladlghclsgilavyanavclagfqgitfyphlhrlrigsdlkvpdifvkydtsnipcglqislpswfkkrdfindtiriafhgidsrkkvaimvaygtlsnpvkvsgtlpskwdhsvtfqkkgngfairllapvgspvilelfeslqrlecvlsmidtlqakkmelrklslsgisfaygpgknlaaniemgtsraraeapcqlrlniqlpfpnlhrriqapladmlnrastadagldsvsdllsltlplmlaldqitanpsrkdtMKVQVIVR.NARNYRIHYPGHQCRFQllAGQYlgRMAWILKDAGGRQG..GDHQEQLRTRL
  982- 1071 (110.00/55.36)	LYDSKG.EGWKGLGNGAVSD.FDKVGNLITQLDKIFHTNQNDlGAATS..SG..PGGE...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lknhkdpILPVAAGQpNGNNGLISPARPDGNAT..TTTG..H..........................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17559 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGIKPRVDVQDSRNGITHPPGSTGNIQNGSFHVNGGMDDQ
2) QNDLGAATSSGPGGELKNHKDPILPVAAGQPNGNNGLISPARPDGNATTTTGHSVKA
11
1019
51
1075










Molecular Recognition Features






MoRF SequenceStartStop




NANANA