<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17468

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMQRYHPAGCASAVNNSTIGGPSARDTARADSSSLSANFGLNSRRQSQLTPYKLKCDKEPLNSRLGPPDFHPPTTNCPEETLTRDYVQSGYKETIEGIEDSREISFTQVQAFTKPVVVKCKEAIRKRFRAINESRAQKRKAGQVYDVPLSGSQLTKPGIFPEQRASGEDFRKKWIEGLSQPHKRLRFLADHVPHGFRRKSLFEILIRNNVPLLRATWFIKVTYLNQVRPGSASISSGAPEKAQLSRTELWTKDVIDYMQYLLDEFFSRNNFHSIPHGRDRSTQVPYAGSLQHRSDLSSAVLDGEEPSLHFKWWYMARLLQWHHAEGLLLPSLIIDWVLNQLQEKDFLEILQFLLPIIYGVLETVVLSQTYVRSLAGVAIRFIREPSPGGSDLVDNSRKAYTTSALVEMLRYLILAVPDTFVALDCFPLPPYVVSHAVNDGNFISKVSGDAEKKKNGSAEVASLFKSKAIDAQYQSLAFDHVVSSIQKRANNLATAARPGYPGRSLAKAVQSLDKSLVHGDVRGACKFLFEDHCDGAIAEGWIAEVSRCLRSSLKWIGTVTLSFVCSVFFLCEWATCDYRDFRTVPPDNLKFSGRKDFCEVYIAIRILKLKVKDLQSSSRGKSGNALGISGVGRGSSQQNSGRTSVGNVFEINNNLRSVDRSCVKSDIFDSPGPLHDIIVCWIDQHEVRNGEGCKRLHLLFVELVRAGIFYPQAYVRQLIVSGILEMNGPVVDLDRRKRHYRILKQLPGLFMCDALEEARIAERPKLLEAMHIYSNERRLVLRGLSCDQRKNSKTANISAQKPIHGKDGVSLAPIEHWKASQSSSNVLPAKNVKNDFDVEELKMAISVLLHFPNNSSLSMDIGLDESQGSVKRDFGSIINKMDLLEGTPGCEECRRAKRQKLSEERSPYLQVHSPIPSDDEDTWWVRKGPKSLESFKVEAPLKSTKQVPRSRQKTVRKTQSLSQLAYSRIEGSQGASTSHVCDGRISCPHHKSGMEGETPKSADGIKTTHCGDIVNIGKALKKLHFGEKRTLTVWLMTVVRQLIEETEKTVVKVGQFGRPFTPVDDRSSIQWKFGEDELSAILYLMDLTNDLVPAVKFLLWLFPKVLSSSNFTIHAGRNVLMLPRNVDNQVCEVGEAFLLSSLRRYENILVAIDLIPQALSATMHRAAAVMASIGRVSGSTALVYARYLLKKYGNVGSVIEWEKSFKATCDKRLLSELESGRSVDGELGFPLGVPAGVEDLDEFFRQKIGGGRSSRVGMNMRDIVQRHIDDTCNYFLGKERKLFAAGPPKGPVFDKWDDGYQVAQLIITGIMDCFRQTGGAAQEGDPSLVSSAVSAIVSNIGPTIAKMPDFPGYNNINISSAAGSLNFSRHILRIHITCLCLLKEALGERQSRVFEIALATEASSALAGVFSPVKASRTQFQLSPEAHESNANMSNESLSSSTKLVFSRSTKIAAAVSALVIGAVIHGATSLERIVTVFRLKEGLDVIQFVRNTRSNSNGNARSIGAPRVDNSVEVYVHWFRLLVGNCRTVCDGLIVELLGKPYIVALSRMQRMLPLSLVFPPAYSIFAYLMWRPFIVNTNLATREDINQLYQSLTMAMVDAIKHLPFRDVCLRDSRGFYDLVAADGSDAEFAAMLELTVSDNHLKSTAFLPLRARIFLNAIIDCKMPQSLSALEDGNRISGHGESRVQYLESETKLLDKLVHVLDTLQPAKFHWQWVELRLLLNEQSLIEKIENHDMSLVDALRSSSPTPEKAAASENENNFIVVILTRLLVRPDAAPLFSEVFHLFGQSLEDSMLLQAKWFLGGQDVLFGRKTIRQRLISIAESKGLSTKPQFWKPWGWFNSGSHPSPKRGDKKFEVSSLEEGEVVEEGIDLKRYGKGSTQILDTEGSNVNLQHVTEQALIELLLPCIDQSSDESRNTFASDLIKQFNGIEQQINAVTRGASKQAGLIPSGIEGPANKGNNRKVMRGGSPGLARRPAGTMDSAPPSPAALRASMSLRLQLLLRFLPIICGDGEPSGRSMRHTLASIILRLLGNRVVYEDADLSFYPTQNYFSKRELESPVEASSAASVDFSGESLFDRLLLVLHGLLSSFQPSWLRSKPTSKSSSEITKESPGLDREVAETLQNDLNRMPLPETIRLRIQTAMPILLPSVHWSVSCQPPSVPGAALALLQPSISTTGVHSCPPQRIPAPLARTAANTSGKFKSMPLQLDHDMEIDPWTLLEDGAGSGPSSSNTAVIGSGDQANLRASSWLKGAVRVRRTDLTYTGAMDEDS
Length2271
PositionKinase
OrganismJuglans regia (English walnut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fagales> Juglandaceae> Juglans.
Aromaticity0.07
Grand average of hydropathy-0.235
Instability index50.11
Isoelectric point8.85
Molecular weight251686.75
Publications
PubMed=27145194

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17468
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.36|      12|      17|     272|     283|       2
---------------------------------------------------------------------------
  272-  283 (22.24/14.15)	SIPHGRDRSTQV
  288-  299 (20.13/11.98)	SLQHRSDLSSAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     278.43|      88|     584|     635|     724|       3
---------------------------------------------------------------------------
  635-  724 (149.94/116.18)	SQQNSGRTSVGNV.FE..INNNLRSVD...RSCVKSDIFDSPG.PLHDIIVCWIDqhEVRNGEGCKRLHLLFVELVRAGIF..YPQAY.VRQLIVSGILE
 1214- 1311 (128.49/92.08)	SELESGRSVDGELgFPlgVPAGVEDLDeffRQKIGGGRSSRVGmNMRDIVQRHID..DTCNYFLGKERKLFAAGPPKGPVFdkWDDGYqVAQLIITGIMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.25|      22|     580|     367|     389|       4
---------------------------------------------------------------------------
  367-  389 (36.12/27.35)	QTYVR...SLAGVAIRFIrEPSPGGS
  951-  975 (33.13/19.57)	QKTVRktqSLSQLAYSRI.EGSQGAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.74|      68|     852|     991|    1067|       5
---------------------------------------------------------------------------
  991- 1067 (100.32/92.56)	SGMEgETPKSADG...IKTTHCGDIVNIGKALKKLHFGEKRTLTVWLMTVVRQLIeeTEKTVVKVgqfgrpFTPVDDRSS
 1842- 1912 (109.42/73.74)	SGSH.PSPKRGDKkfeVSSLEEGEVVEEGIDLKRYGKGSTQILDTEGSNVNLQHV..TEQALIEL......LLPCIDQSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17468 with Med12 domain of Kingdom Viridiplantae
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