<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17467

Description mediator of RNA polymerase II transcription subunit 12 isoform X3
SequenceMQRRQSQLTPYKLKCDKEPLNSRLGPPDFHPPTTNCPEETLTRDYVQSGYKETIEGIEDSREISFTQVQAFTKPVVVKCKEAIRKRFRAINESRAQKRKAGQVYDVPLSGSQLTKPGIFPEQRASGEDFRKKWIEGLSQPHKRLRFLADHVPHGFRRKSLFEILIRNNVPLLRATWFIKVTYLNQVRPGSASISSGAPEKAQLSRTELWTKDVIDYMQYLLDEFFSRNNFHSIPHGRDRSTQVPYAGSLQHRSDLSSAVLDGEEPSLHFKWWYMARLLQWHHAEGLLLPSLIIDWVLNQLQEKDFLEILQFLLPIIYGVLETVVLSQTYVRSLAGVAIRFIREPSPGGSDLVDNSRKAYTTSALVEMLRYLILAVPDTFVALDCFPLPPYVVSHAVNDGNFISKVSGDAEKKKNGSAEVASLFKSKAIDAQYQSLAFDHVVSSIQKRANNLATAARPGYPGRSLAKAVQSLDKSLVHGDVRGACKFLFEDHCDGAIAEGWIAEVSRCLRSSLKWIGTVTLSFVCSVFFLCEWATCDYRDFRTVPPDNLKFSGRKDFCEVYIAIRILKLKVKDLQSSSRGKSGNALGISGVGRGSSQQNSGRTSVGNVFEINNNLRSVDRSCVKSDIFDSPGPLHDIIVCWIDQHEVRNGEGCKRLHLLFVELVRAGIFYPQAYVRQLIVSGILEMNGPVVDLDRRKRHYRILKQLPGLFMCDALEEARIAERPKLLEAMHIYSNERRLVLRGLSCDQRKNSKTANISAQKPIHGKDGVSLAPIEHWKASQSSSNVLPAKNVKNDFDVEELKMAISVLLHFPNNSSLSMDIGLDESQGSVKRDFGSIINKMDLLEGTPGCEECRRAKRQKLSEERSPYLQVHSPIPSDDEDTWWVRKGPKSLESFKVEAPLKSTKQVPRSRQKTVRKTQSLSQLAYSRIEGSQGASTSHVCDGRISCPHHKSGMEGETPKSADGIKTTHCGDIVNIGKALKKLHFGEKRTLTVWLMTVVRQLIEETEKTVVKVGQFGRPFTPVDDRSSIQWKFGEDELSAILYLMDLTNDLVPAVKFLLWLFPKVLSSSNFTIHAGRNVLMLPRNVDNQVCEVGEAFLLSSLRRYENILVAIDLIPQALSATMHRAAAVMASIGRVSGSTALVYARYLLKKYGNVGSVIEWEKSFKATCDKRLLSELESGRSVDGELGFPLGVPAGVEDLDEFFRQKIGGGRSSRVGMNMRDIVQRHIDDTCNYFLGKERKLFAAGPPKGPVFDKWDDGYQVAQLIITGIMDCFRQTGGAAQEGDPSLVSSAVSAIVSNIGPTIAKMPDFPGYNNINISSAAGSLNFSRHILRIHITCLCLLKEALGERQSRVFEIALATEASSALAGVFSPVKASRTQFQLSPEAHESNANMSNESLSSSTKLVFSRSTKIAAAVSALVIGAVIHGATSLERIVTVFRLKEGLDVIQFVRNTRSNSNGNARSIGAPRVDNSVEVYVHWFRLLVGNCRTVCDGLIVELLGKPYIVALSRMQRMLPLSLVFPPAYSIFAYLMWRPFIVNTNLATREDINQLYQSLTMAMVDAIKHLPFRDVCLRDSRGFYDLVAADGSDAEFAAMLELTVSDNHLKSTAFLPLRARIFLNAIIDCKMPQSLSALEDGNRISGHGESRVQYLESETKLLDKLVHVLDTLQPAKFHWQWVELRLLLNEQSLIEKIENHDMSLVDALRSSSPTPEKAAASENENNFIVVILTRLLVRPDAAPLFSEVFHLFGQSLEDSMLLQAKWFLGGQDVLFGRKTIRQRLISIAESKGLSTKPQFWKPWGWFNSGSHPSPKRGDKKFEVSSLEEGEVVEEGIDLKRYGKGSTQILDTEGSNVNLQHVTEQALIELLLPCIDQSSDESRNTFASDLIKQFNGIEQQINAVTRGASKQAGLIPSGIEGPANKGNNRKVMRGGSPGLARRPAGTMDSAPPSPAALRASMSLRLQLLLRFLPIICGDGEPSGRSMRHTLASIILRLLGNRVVYEDADLSFYPTQNYFSKRELESPVEASSAASVDFSGESLFDRLLLVLHGLLSSFQPSWLRSKPTSKSSSEITKESPGLDREVAETLQNDLNRMPLPETIRLRIQTAMPILLPSVHWSVSCQPPSVPGAALALLQPSISTTGVHSCPPQRIPAPLARTAANTSGKFKSMPLQLDHDMEIDPWTLLEDGAGSGPSSSNTAVIGSGDQANLRASSWLKGAVRVRRTDLTYTGAMDEDS
Length2231
PositionKinase
OrganismJuglans regia (English walnut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fagales> Juglandaceae> Juglans.
Aromaticity0.07
Grand average of hydropathy-0.231
Instability index50.42
Isoelectric point8.84
Molecular weight247723.57
Publications
PubMed=27145194

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17467
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     410.12|     109|     224|     926|    1045|       1
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  926- 1042 (170.28/125.94)	SRIEGSQgaSTSHVCDGRISCphhkSGMEGETPKSADG...IKTTHCG...DIVNIGKALK.KLHFGEKRTLTVWLMTVVRQLIEETEKTVV....KVGQFGRPFTPVDDRSSiqWKFGEDELSAILY
 1156- 1267 (159.34/96.88)	SVIEWEK..SFKATCDKRLLS.......ELESGRSVDG...ELGFPLGvpaGVEDLDEFFRqKIGGGRSSRVGMNMRDIVQRHIDDTCNYFLgkerKLFAAGPPKGPVFDK....WDDGYQVAQLIIT
 1802- 1872 (80.49/43.49)	.........................SGSH.PSPKRGDKkfeVSSLEEG...EVVEEGIDLK.RYGKGSTQILDTEGSNVNLQHV..TEQALI....EL......LLPCIDQSS...............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.34|      38|     224|     468|     508|       2
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  468-  508 (60.48/40.06)	VQSLDKSLVHGDVRGACKFLFedHCDgAIAEGWIAEVSRCL
  689-  726 (66.86/34.71)	VVDLDRRKRHYRILKQLPGLF..MCD.ALEEARIAERPKLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17467 with Med12 domain of Kingdom Viridiplantae
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