<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17456

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTLDFSALVTRAAEDSFLSLKELVDKEKSRSSSTSASAAGDPQSDTERKINLLKYIYKTQQRMLRLNVLAKWCQQVPLIQYCQQLSSTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYQRIPKCIENVGIQSTLNEDQQKPALKKLDMLVRTKLLEVSLPREISEVKVSDGTAQLRVDGEFKVLVTLGYRGHLSMWRILHMELLVGERSGLVKLEESRRHILGDDLERRMAAAENPFLTLYSVLHEFCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSTGHGGSAGSTQLNPDGEADSSGLRTPGLKILYWLDFDKNVGTPDSTSCPFIKIEPGPDLHIKCLHSTFIIDPITGKEAELFLDQSCIDVDKLLLKAICCNRYTRLLEIQKELGKNVQICRTAGDVVLQLPLDELDIDYRKNDKKSDSREYEGQEVLRVRAYGSSFFTLGINIRNGSFLLQTSRNILEPSVLSDCEEALNQGSMTAAEVFISLRSRSIMHLFASIGRFLGLEVYEHGFAAVKVPKNMLNGSSMLLMGFPDCGSSYFLLMLLDKEFKPLFKLLETQPDPSGKAHSFNDLNHVVRIKKIDIGQMQMLEDEMNLSLLDWGKLLSFLPSSGGPNHSSEHGILPEIGPESSMQIAGCPPSSFSSFVDEVFELEKGSSAIPFSVHNLSSSYSTSPASHFVSAPMNLHTMKAKTPSPKWEGSMQISQINNISKVSSMTTHYNGSLYSLSNLKGPAQSHSLSSLSSGTGRGTTMKKLSASKSEQDLASLRSTHSVEVGSGSPMDEDQLRLLNDTSNDAYGSKSARLLSPQVTAPRMSVPGAKSNGIRNSPSRPLAGSLRIAGSSSCTTTPVSHAPESAICPSPSQDVVSKHDKNPRKRTVSDVLNLIPSLQGLEAASRFCKRRKISEYAHALHPSSQAPISTEVVTKMEGYSYGNLIGEANKGNASSSIYVSALLHVVRHCSLSIKHARLTSQMEALDIPYVEEVGLRNASSNIWFRLPFARGDSWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNSTLWGSGVRIANTSDIDSHIRYDPDGVVLSYQSVDADSIKKLVADIRRLSNARMFALGMRKLLGIRGDEKPEECSTNSDVKAPIGAKGAPETADKLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPGPGVPGVAAALSSIPKQAGYIATSQGLLPSNSTTSIGQATSVPVGNPAAPSGTGTLANHGLHGAAMLTAAGRSGPGIVPSSLLPIDVSVVLRSPYWIRIIYRKNFAVDMRCFAGDQVWLQPATPPKGGSSVGGSLPCPQFRPFIMEHVAQELNGLDPNFTGGQQMGGLANSNTHNPISGSQLSAANGNRINLPSSAVMARVGTQVSGLNRVGNTLSGSPNLAVVGSGMALRRTPGTSVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPNLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQNSPAAQEELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISILREFLKLIAWKKGLAQAQGGDIAPAQKPRIELCLENHTGLNMDDNSENSSVAKSNIHYDRPHNSVDFALTVVLDPALIPHINAAGGAAWLPYCVSVRLRYAFGENPSVSFLDMEGSHGGRACWFRADDWEKCKQRVARTVELNGSSAADVNQGRLRIVADTVQRALHSYLQGLRDGGGITASSGSM
Length1843
PositionTail
OrganismJuglans regia (English walnut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fagales> Juglandaceae> Juglans.
Aromaticity0.06
Grand average of hydropathy-0.188
Instability index43.20
Isoelectric point7.97
Molecular weight200482.06
Publications
PubMed=27145194

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17456
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.19|      15|      49|     581|     595|       1
---------------------------------------------------------------------------
  581-  595 (27.86/16.15)	KLLETQPDPSGKAHS
  629-  643 (28.33/16.57)	KLLSFLPSSGGPNHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.53|      19|      19|     786|     804|       2
---------------------------------------------------------------------------
  786-  804 (31.86/15.53)	EQDLASLRSTHSVEVGSGS
  808-  826 (30.66/14.69)	EDQLRLLNDTSNDAYGSKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.76|      32|      43|    1416|    1457|       3
---------------------------------------------------------------------------
 1418- 1456 (46.17/38.28)	QMGGLanSNTHNPISGSQLSAANGNRINLPSSAvmarvG
 1458- 1489 (55.59/27.45)	QVSGL..NRVGNTLSGSPNLAVVGSGMALRRTP.....G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.58|      41|      49|    1031|    1073|       4
---------------------------------------------------------------------------
 1031- 1073 (71.30/58.72)	HIclRLGRPGSMYWDVKINDQHFRDL.WELQKGSNSTLWGSGVR
 1083- 1124 (64.28/44.93)	HI..RYDPDGVVLSYQSVDADSIKKLvADIRRLSNARMFALGMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.95|      45|      49|     908|     952|       6
---------------------------------------------------------------------------
  857-  902 (50.67/33.30)	.LAGSLR..IAGSSSCTTTPVSHAPEsAICPSpSQDVVSKhdKNPRKRT
  908-  952 (73.78/52.66)	NLIPSLQGLEAASRFCKRRKISEYAH.ALHPS.SQAPIST..EVVTKME
  958-  998 (62.49/43.21)	NLIGEANKGNASSSIY....VSALLH.VVRHC.SLSIKHA..RLTSQME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.12|      34|      52|    1250|    1283|       7
---------------------------------------------------------------------------
 1250- 1283 (59.34/34.86)	ARAGPGP.GVPGV.AAALSSIPKQAGYIATSQGLLP
 1303- 1338 (50.78/28.63)	APSGTGTlANHGLhGAAMLTAAGRSGPGIVPSSLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.86|      30|      43|     680|     720|       8
---------------------------------------------------------------------------
  680-  714 (44.01/54.31)	KGSSAIPfSVHNLS...........SSYSTSPashfVSAPMNLHTM
  724-  764 (43.85/22.61)	EGSMQIS.QINNISkvssmtthyngSLYSLSN....LKGPAQSHSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17456 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PVSHAPESAICPSPSQDVVSKHDKNPRKRTVS
2) QSHSLSSLSSGTGRGTTMKKLSASKSEQDLASLRSTHSVEVGSGSPMDEDQLRLLNDTSNDAYGSKSARLLSPQVTAPRMSVPGAKSNGIRNSPSRPLAGSLRIAGSSSCTT
873
760
904
871










Molecular Recognition Features






MoRF SequenceStartStop




NANANA