<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17447

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVEFSALVTRAAEDSFLALNELVEKEKSRPSSTSASAARDPQSDTERKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLGSILSSHDTCFTQAADSLFFMHEGSRQVHAPVHDVPSAIEVLLTGSYQCLPKCVENVGIQSTLSEDEQKPALKKLDTLVQSKLLEVSLPKEISEVKVSNGTALLRVDGEFEVLVTLGYRGHLSMWRILHLELLVGERSGLVKLEESRRHVLGDDLERRMAAAENPFMTLYTVLHELCIVLIMDTVIRQVKALRQGRWKDTIRFELVSDGSISHGGSASSTQLNLDGESDFSALQTPVLKVLYWLDFDKISRTSESKSCPFIKIEPGQDLHIKCLHSTFVIDPLTGMEAEFYLNQSYIDVEKLLLRAICCNRYTRLLEIQKELGKSVQICRVADDVVLQSNLDEPDVDYKRNDKKSDSREYEGQEVLRVRAYGSSFFTLGINIRNGCFLLQSSQNILEPSVLLDCEEALNQGIMTVGEVFMSLRSKSILHLFASIGRFLGLEVYDHGFAAVKVPKNMVNGSSMLLMGFPDCGSSYFLLMLLDEEFKPLFKLLETQPDGPDPSGKAHSSNNLNHVIHIKKIDIGQMQILEDEMNMSLLNWGKLLSFMPSAAGSNGGSEQGILPEIGLESSMQLSGCPPSFSSAVDEVFGHEKGSPTIPFSVQNISSYSTSRASYFGSPPMNLHAMKAATPSPKWDTGMQISQINNVAKVSSMDTHYIASLHSSSNLKGPLLSNSVGSLSSGTGRSTTMKKLSASKSEQDLASLRSGHLIEVGSCTTMDDDQLRLISDNSKDTYGSRSARLLSHPQATSPQITVPGVKTNGLQSSPSRPVAGSSSCTTTPVSHPPESAIQSPSQDLVSKHDRNPRKHTVSDILSLIPSLQGLEAASGFCKKRKIAESVSALQPSTQAPISTEMVTKTEGYSYGKLIVEAYKGNTCCPLTNTPSGIYVSALLHVVRHCSLCIKHARLTSQMEALDIPYVEEVGLKNASSCIWFRLPFARGDLWKHICLRLGRPGSMYWDVKIKDQHFRDLWDLQKGSSNTPWGSGIRIANTSDIDSHIQYDLDGVVLSYQSVEADSMKKLVADIRRLSNARLFALGMQKLLGVQADEKLEECCTNSDVKAPTGIRGAPGTADKLSEQMRRAFRIEAIGLMSLWFSFGSGVLARFVVEWESSKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLPDCIRLTAGPLHALAAATRPARAGPVSRVTGVVAAVSSIPKQAGYMTSSLGLLPGNSAMNVSQAGSVPVGNPTASSATSILANQGLHGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFAVDMRCFAGDQVWLQPVTPPKGGSSIGGSLPCPQFRPFIMEHVAQELNGLDPNFTSGQQMVGGLGNSNTQNPSSGSQLSAANGNRVNLLSSAAMARAGNQIAGLNHVGNTLSGSSSLAVVGSGVALRRSPGTSVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPHLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQQNSAAQEELAHSEISEICDYFSRRVASEPYDTPRVASFITLLTLPISILREFLKLIAWKKGLALAQGGDIAPAQKPRIELCLENHTGLNNENNSENSSVAKSNIHYDRPHNSVDFALTVVLDPTHIPYINAAGGAAWLPYCVSVRLRYLFGENPSVSFLDMEGSHGGQACWFPVDDWEKCKQRVARAVEVNGSSPADVSQGRLRLVADGVQRTLHLCLQGLRDGGGFTASSGSK
Length1846
PositionTail
OrganismJuglans regia (English walnut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fagales> Juglandaceae> Juglans.
Aromaticity0.06
Grand average of hydropathy-0.132
Instability index44.68
Isoelectric point6.88
Molecular weight200814.93
Publications
PubMed=27145194

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP17447
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.03|      19|      22|    1520|    1540|       1
---------------------------------------------------------------------------
 1516- 1535 (31.88/22.22)	Y.GGGWV....PLVaLKKVLRGILK
 1536- 1559 (26.15/17.90)	YlGVLWLfaqlPHL.LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.02|      19|      22|    1436|    1456|       2
---------------------------------------------------------------------------
 1418- 1433 (28.45/15.64)	GQQMVGGL..GN.....SNTQNP
 1436- 1456 (25.95/20.44)	GSQLSAAN..GNrvNLLSSAAMA
 1459- 1479 (26.62/14.10)	GNQIAGLNhvGN..TLSGSSSLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.60|      17|      22|     753|     771|       4
---------------------------------------------------------------------------
  753-  771 (24.67/16.37)	SSNLKGplLSNS.....VGSLSSG
  775-  796 (22.93/ 8.95)	STTMKK..LSASkseqdLASLRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.80|      19|      27|    1301|    1319|       5
---------------------------------------------------------------------------
 1301- 1319 (33.27/18.22)	GNP..TASSATSILANQGLHG
 1329- 1349 (28.53/14.52)	GGPgiVPSSLLPIDVSVVLRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.52|      17|      22|    1095|    1111|       6
---------------------------------------------------------------------------
 1095- 1111 (28.84/23.20)	LSYQSVEADSMKKLV...AD
 1115- 1134 (23.68/17.39)	LSNARLFALGMQKLLgvqAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.17|      22|      25|     863|     885|       7
---------------------------------------------------------------------------
  863-  885 (36.68/27.26)	SSCTTTPVSHpPESAIQS..PS.QDL
  887-  911 (31.49/17.38)	SKHDRNPRKH.TVSDILSliPSlQGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.32|      16|      21|     683|     700|       9
---------------------------------------------------------------------------
  683-  700 (24.32/15.32)	GSPtiPFSVQNISSYSTS
  706-  721 (29.00/13.02)	GSP..PMNLHAMKAATPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.99|      22|     407|    1356|    1378|      10
---------------------------------------------------------------------------
 1356- 1378 (39.76/31.00)	IYRKNFAV...DMRCFAGDQV.WLqPV
 1761- 1786 (35.22/21.74)	LFGENPSVsflDMEGSHGGQAcWF.PV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.21|      14|      16|     803|     816|      14
---------------------------------------------------------------------------
  803-  816 (25.27/16.79)	SCTTMDDDQLRLIS
  819-  832 (22.94/14.48)	SKDTYGSRSARLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.99|      19|      25|    1029|    1051|      15
---------------------------------------------------------------------------
 1029- 1051 (27.53/31.13)	DLWKhicLRLGRPGSmYWDVKIK
 1057- 1075 (37.46/23.30)	DLWD...LQKGSSNT.PWGSGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.58|      18|     297|     537|     564|      16
---------------------------------------------------------------------------
  543-  562 (30.08/37.13)	KVPKNMVNGSSmlLMGFPDC
 1217- 1234 (32.50/ 9.73)	KFLEDFINGAE..VASLPDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.77|      31|     732|     995|    1025|      25
---------------------------------------------------------------------------
  995- 1025 (55.94/36.20)	LTSQMEALDIPYVEEVGLKN.ASSCIWFRLPF
 1729- 1760 (50.83/32.19)	LTVVLDPTHIPYINAAGGAAwLPYCVSVRLRY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17447 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSNSVGSLSSGTGRSTTMKKLSASKSEQDLAS
2) YGSRSARLLSHPQATSPQITVPGVKTNGLQSSPSRPVAGSSSCTTTPVSHPPESAIQSPSQDLVSKHDRNP
761
823
792
893










Molecular Recognition Features






MoRF SequenceStartStop




NANANA