<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17433

Description mediator of RNA polymerase II transcription subunit 16 isoform X1
SequenceMSQDSGPKEAEDEPAASESIEVSKGAEDTEPAASAEEDAVEKPDDPMDEDSVSPATVFCIRLKQPRSNLQHKMSVPELCRNFSAVAWCGKLNAIACASETCARIPSSNANPPFWIPIHIVIPERPTECAVFNVTADSPRDSVQFIEWSPTSCPRALLIANFHGRITIWTQPSQGSASLVRDASCWQPEHEWRQDIAVVTKWLSGVSQYRWLSSKAGTAVNSKSAFEEKFLSQQSQTSARWPNFLCVCSVFSSGSIQLHWSQWPPSQNGVALKWFSTSKGLLGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTVVVWEVTPGPGNAFQATPKTSSSNGVPPSLNPPSWAGFAPLAAYLFSWQEYLISEAKQGKRTDQDLNDTVPLHCSPVSNFSAYVSPEAAAQSAATTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSLKPVVLHQIFGNPTSSYGGQAPMQTVWVSKVDTSIPPTNDFKSHEAAATGPTSDVRKTSDLTVDKGQKVIFDPFDLPSDVRTLARIVYSAHGGEIAIAFLRGGVHIFSGPNFAPVDNYQINVGSAIAAPAFSSTSCCSASVWHDTSKDRTMLKIIRVLPPAVPSSQAKANSSTWERAIAERFWWSLLVGVDWWDAVGCTQSAAEDSIVSLNSVIAVLDADFHSLPSTQHRQQYGPSLDRIKCRLLEGTNAQEVRAMVLDMQARLLLDMLGKGIESALLNPSALVPEPWHESGETLSGIDPEAMAVEPALVLSIQAYVDAVLDLASHFITRLRRYASFCRTLASHAVTAGTGSNRNMVASPTQSSATPATSQGGQSGTASSTGSTQMQAWVQGAIAKISSTNDGVSNSTPNPISGPSSFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFFFRRTQLPRFLLGAQRNAETNMQKPQPSAPSKLEEINSISAKPASAVARSEDGQISRVNQLLPGAKGVEEGPAGRSRLGSGNAGQGYTFEEVRVLFLILMDLCRRTVGLAHPLPVSQVGSNNIQVRLHYIDGNYTVLPEVVEASLGPHMQNMPRPRGADAAGLLLRELELHPPAEEWHRRNMYGGPWSDPDDMGHVDDSPKLRNSGDPIDFNSLENSDVYYGPHSLWPRKRRMSERDAAFGLNTSVGLGAYLGIMGSRRDVVTAVWKTGLEGVWYKCIRCLRQTSAFASPGASHPPNQNDRETWWISRWAYGCPMCGGTWVQVV
Length1239
PositionTail
OrganismJuglans regia (English walnut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fagales> Juglandaceae> Juglans.
Aromaticity0.08
Grand average of hydropathy-0.218
Instability index44.51
Isoelectric point5.88
Molecular weight133937.27
Publications
PubMed=27145194

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17433
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.25|      10|      19|       8|      17|       1
---------------------------------------------------------------------------
    8-   17 (19.65/11.70)	KEAED.EPAAS
   24-   34 (15.60/ 7.63)	KGAEDtEPAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.78|      17|      19|     774|     790|       2
---------------------------------------------------------------------------
  774-  790 (28.66/19.08)	IQAYVDAVLDLASHFIT
  792-  808 (30.12/20.42)	LRRYASFCRTLASHAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.03|      16|      19|     185|     200|       3
---------------------------------------------------------------------------
  185-  200 (31.33/16.10)	WQ...PEHEW...RQDIAVVTK
  201-  222 (19.70/ 7.70)	WLsgvSQYRWlssKAGTAVNSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.31|      15|      19|     819|     833|       4
---------------------------------------------------------------------------
  819-  833 (26.89/13.58)	ASPTQSSATPATSQG
  839-  853 (28.41/14.76)	ASSTGSTQMQAWVQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.07|      25|     529|     329|     354|       5
---------------------------------------------------------------------------
   93-  117 (37.31/19.43)	AIACASETCaRIPSSnA.NP...PFW...IPI
  329-  354 (46.34/30.71)	ATPKTSSSN.GVPPS.L.NP...PSWaGFAPL
  854-  882 (32.42/15.74)	AIAKISSTNdGVSNS.TpNPisgPS..SFMPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     229.68|      61|     806|     372|     432|       6
---------------------------------------------------------------------------
  372-  432 (103.61/53.41)	GKRTDQDLNDTVPLHCSPVSNFSAYVSPEAA...AQSAATTTWGSGVTAVAFD.PTRGGSVIAVV
  447-  499 (77.29/37.96)	GPSITGWRVQRWESSLKPVVLHQIFGNPTSS.ygGQAPMQTVWVSKVD.TSIP.PT.........
 1200- 1239 (48.77/21.22)	......................SAFASPGAShppNQNDRETWW...ISRWAYGcPMCGGTWVQVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.13|      16|      19|     733|     748|       8
---------------------------------------------------------------------------
  733-  748 (27.22/17.26)	GIESALLNPSALVPEP
  753-  768 (27.91/17.90)	GETLSGIDPEAMAVEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      16|      19|     966|     982|       9
---------------------------------------------------------------------------
  966-  982 (24.17/20.70)	EDGQISRvNQLLPGAKG
  984-  999 (28.79/19.45)	EEGPAGR.SRLGSGNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.44|      13|      19|     229|     241|      10
---------------------------------------------------------------------------
  229-  241 (25.03/15.75)	FLSQQSQTS.ARWP
  250-  263 (21.41/12.20)	FSSGSIQLHwSQWP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.87|      12|      19|     147|     158|      11
---------------------------------------------------------------------------
  147-  158 (23.66/13.03)	WSPTSCPRALLI
  168-  179 (22.21/11.70)	WTQPSQGSASLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.31|      22|     534|     637|     659|      15
---------------------------------------------------------------------------
  637-  659 (40.27/27.49)	RAIAERFWWSLLVGVdWWDAVGC
 1174- 1195 (43.04/24.77)	RDVVTAVWKTGLEGV.WYKCIRC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17433 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTGSNRNMVASPTQSSATPATSQGGQSGTASSTG
2) MSQDSGPKEAEDEPAASESIEVSKGAEDTEPAASAEEDAVEKPDDPMDEDS
810
1
843
51










Molecular Recognition Features






MoRF SequenceStartStop




1) QDSGPKEAEDEPAASESIEVSKGAEDTEPAASAEED
3
38