<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17411

Description cyclin-dependent kinase E-1
SequenceMGDGNATNNRGLSSNNKPEWLQQYDLIGKIGEGTYGLVFLARIKSPTANRGKSIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINHTDMSLYLAFDYAEHDLYEIIRHHRDKVNHVISQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGEGDEQGVVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGVEVKGNPNPFQLDQLDKIFKVLGHPTPEKWPTLANLPHWQQDLQHIQGHKYENTGLYNVVHLSPKTPAYDLLSRMLEYDPRKRLTASQALEHEYFRNDPLPGRNALVCQTGEKVNYPTRPVDTSTDFEGTTSLQPPQTVSSGNAVSGTMSGAHGGTMRSVPRQMAVGGMQRMQPQGMPAYNITSQAGMGGGMNPNGIPMQRGVPAQAHQQQLRRKDPGMGTNIYPPQQKSRRL
Length473
PositionKinase
OrganismJuglans regia (English walnut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fagales> Juglandaceae> Juglans.
Aromaticity0.07
Grand average of hydropathy-0.480
Instability index36.92
Isoelectric point9.25
Molecular weight52817.69
Publications
PubMed=27145194

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17411
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.14|      16|      17|     439|     454|       1
---------------------------------------------------------------------------
  397-  411 (27.29/13.00)	M.RSV.PRQMAVGGMQR
  439-  454 (29.72/14.69)	MQRGV.PAQAHQQQLRR
  459-  472 (20.13/ 8.02)	MGTNIyPPQ...QKSRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.59|      16|      18|     317|     332|       2
---------------------------------------------------------------------------
  317-  330 (19.82/10.01)	...EY...DPRKRLTASQAL
  331-  346 (20.23/10.36)	EH.EYfrnDP...LPGRNAL
  352-  367 (21.54/11.49)	EKvNY....PTRPVDTSTDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.36|      27|      42|     163|     191|       5
---------------------------------------------------------------------------
  163-  191 (42.78/36.34)	LVMGEGDEQGVVKIGDFGLarIYQA..PLKP
  208-  236 (43.58/30.05)	LLLGAKHYTSAVDMWAVGC..IFAEllTLKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17411 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPGRNALVCQTGEKVNYPTRPVDTSTDFEGTTSLQPPQTVSSGNAVSGTMSGAHGGTMRSVPRQMAVGGMQRMQPQGMPAYNITSQAGMGGGMNPNGIPMQRGVPAQAHQQQLRRKDPGMGTNIYPPQQKSRRL
340
473










Molecular Recognition Features






MoRF SequenceStartStop




1) LRRKDPGMGTNIYPPQQKSRRL
2) RGKSIAIKKFK
452
50
473
60