<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17393

Description mediator of RNA polymerase II transcription subunit 14 isoform X1
SequenceMAPVQIGSDGQLVPLGGPVVSGPQPPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLALLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKVEKQTTLSQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRTLVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEEKYVPAKYLTLSVWNQQILGKKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTINDDMKRILTWLQQLKFWLGEQRCRQSVKHLPSVCTDVLHLSNSPSHPVGSLSKHKLFIKLTRLPQYYIVVEMLEVPNSPAALQYKYSFLSVLQLEGEDGPMCAQLLQHFKPNLEHLVQDTTAGRETRPGTKRKVSGEQGDPEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMEMANEGVQVEGDSSSHAIRLLKIPPCKDVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLANCPLHSTHSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWKAISQLYQCVLNFSRAIPDMPSILSVFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSSSLRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVLQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDMMDSLMNQLQAPQQPQTMRGGPGGVYPPLTSPPPNYHANVTPSPSMLHTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGTSSQIMPTSMPPPRKLPQRPWAASIPTILTHSALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQESNLAIVNSNEPGVIMFKTDMLKCRVALNPKNYQTLQIKVTPENAGPWSQEELQVLERFFETRVAGPPFKFNTLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKAKMLFFLQLTQRVPAPQEPVTIIVPIVYDMATGLTQQADIPRQHSSSGAAALLVSNILKRFNELHPARQGECTIFASVHELMANLTLPPGTRQ
Length1435
PositionTail
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.06
Grand average of hydropathy-0.179
Instability index51.42
Isoelectric point8.66
Molecular weight159107.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17393
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     638.42|     194|     272|     810|    1013|       1
---------------------------------------------------------------------------
  810- 1011 (321.96/195.31)	QWNSSSLRFHLALGTVGPNSGCS....NCHNIILHQ.LQEMFNKNPNVLQLLQVLYDTQAPLNAINKLPTV.PM.LGL..TQRTNTAYQCFsILPqSPTHIRL.AFRNMYCIDIYCRSRGVVAIRDGAYSLF...DNTKIVEGfyPAPGLKTF.LNMF...VDSN....QDARRRSVNEDDNPPSPVGVDMMDSLM.NQLQAPqqPqtMRGGPGGVYPPLTSPP
 1090- 1291 (270.64/139.89)	QWPGSP.......QVSGPSPGARipgmSPGNPSLHSpIPD..PHSPRAGTSSQIMPTSMPP...PRKLPQR.PW.AASipTILTHSALHVL.LLP.SPTPCLVpGLAGSYLCSPLERFLGSVIMRRHLQRIIqqeSNLAIVNS..NEPGVIMFkTDMLkcrVALNpknyQTLQIKVTPENAGPWSQEELQVLERFFeTRVAGP..P..FKFNTLSAFTKLLGAP
 1317- 1385 (45.83/15.01)	.....NVQFCLTIPPSAPPIAPP....GTIAVVLKA.KMLFF......LQLTQRVPAPQEPVTII..VPIVyDMaTGL..TQQADIPRQ.......................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     615.10|     156|     273|     129|     313|       2
---------------------------------------------------------------------------
  129-  293 (250.25/180.63)	DALVHARLPSFAIPFaidvlTTGSYPRLPTCIRDKI..IPPD.......PITKVEKQT.TLSQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEilvEDKETGD..GRTLVHSL........QVNFIHELvQARLCADEKP..LQDMYNC.LHSFCLSLQLE
  415-  564 (191.54/117.95)	NSFIETALPTLVIPI............LEPCGRSEClhIFVDlhsgmfqPMLYGLDQS.MLDDIE.....KTINDDMKRILTWLQ....QLKFWL.GEQRCRQSV.KHLPSVCTDVLHLS...NSPSHPV..GSLSKHKLfikltrlpQYYIVVEM....LEVPNSPaaLQYKY.....SFLSVLQLE
  590-  720 (173.31/143.31)	....................TAGRETRPGTKRKVSG..EQGD.......PEPKKPKRSgEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMEMANEG.....VQVEGDSSSHAIRLLKIP...PCKDVGEetRRALERSL.........LDCTFRL.QGRNNRTWVA..ELVLANCpLHS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.92|      28|      30|    1019|    1048|       3
---------------------------------------------------------------------------
 1019- 1048 (45.68/32.04)	TPSPSMLHTqSPGNIhASGSPSGALRAPSP
 1052- 1079 (55.25/29.64)	TPSPSSLGI.AMGQT.SFASPHGPLDPSSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17393 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVQDTTAGRETRPGTKRKVSGEQGDPEPKKPKRSGE
2) NQDARRRSVNEDDNPPSPVGVDMMDSLMNQLQAPQQPQTMRGGPGGVYPPLTSPPPNYHANVTPSPSMLHTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGTSSQIMPTSMPPPRKLPQRPWA
585
957
620
1151










Molecular Recognition Features






MoRF SequenceStartStop




NANANA