<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17392

Description mediator of RNA polymerase II transcription subunit 14 isoform X2
SequenceMAPVQIGSDGQLVPLGGPVVSGPQPPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLALLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKVEKQTTLSQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRTLVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEEKYVPAKYLTLSVWNQQILGKKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTINDDMKRILTWLQQLKFWLGEQRCRQSVKHLPSVCTDVLHLSNSPSHPVGSLSKHKLFIKLTRLPQYYIVVEMLEVPNSPAALQYKYSFLSVLQLEGEDGPMCAQLLQHFKPNLEHLVQDTTAGRETRPGTKRKVSGEQGDPEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMEMANEGVQVEGDSSSHAIRLLKIPPCKDVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLANCPLHSTHSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWKAISQLYQCVLNFSRAIPDMPSILSVFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSSSLRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVLQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDMMDSLMNQLQAPQQPQTMRGGPGGVYPPLTSPPPNYHANVTPSPSMLHTQSPGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGTSSQIMPTSMPPPRKLPQRPWAASIPTILTHSALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQESNLAIVNSNEPGVIMFKTDMLKCRVALNPKNYQTLQIKVTPENAGPWSQEELQVLERFFETRVAGPPFKFNTLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKAKMLFFLQLTQRVPAPQEPVTIIVPIVYDMATGLTQQADIPRQHSSSGAAALLVSNILKRFNELHPARQGECTIFASVHELMANLTLPPGTRQ
Length1394
PositionTail
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.06
Grand average of hydropathy-0.179
Instability index50.12
Isoelectric point8.62
Molecular weight155193.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17392
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     442.07|     150|     280|     156|     435|       1
---------------------------------------------------------------------------
  129-  313 (204.51/317.67)	DALVHARLPSFAIPFaidVLTTGSyprLPtcirdkiIPPD.......PITKVEKQTTLSQLNqilrhRLVTTDLPPQLANLTvangRVKFRVeGEFEATLTVmGDDPDIPWRLLKLEilvEDKETGDGRTLVHSL........QVNFIHELvqarLCADEKP..LQDMYnclhSFCLSLQLE....VLHSQTLMLIRERWGDLVQE
  415-  588 (237.56/120.56)	NSFIETALPTLVIPI...LEPCGRsecLH.......IFVDlhsgmfqPMLYGLDQSMLDDIE.....KTINDDMKRILTWLQ....QLKFWL.GEQRCRQSV.KHLPSVCTDVLHLS...NSPSHPVGSLSKHKLfikltrlpQYYIVVEM....LEVPNSPaaLQYKY....SFLSVLQLEgedgPMCAQLLQHFKPNLEHLVQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.16|      40|     280|    1005|    1044|       2
---------------------------------------------------------------------------
 1005- 1044 (78.58/36.46)	PPLTSPPPN...YH.ANVTP.SPSML.HTQSPGPLDPSSPYTMVSP
 1054- 1091 (59.70/25.86)	PQVSGPSPG...ARiPGMSPgNPS.L.H..SPIP.DPHSPRAGTSS
 1094- 1136 (60.89/26.53)	MPTSMPPPRklpQR.PWAAS.IPTILtHSALHVLLLP.SPTPCLVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.79|      37|     123|     736|     778|       3
---------------------------------------------------------------------------
  736-  778 (51.92/48.65)	YEN..PLsEPVGGRKVVEMfLNDWKAISQLYQCvlnFSrAIPDMP
  860-  898 (63.86/36.71)	YDTqaPL.NAINKLPTVPM.LGLTQRTNTAYQC...FS.ILPQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.26|      85|     582|      20|     110|       6
---------------------------------------------------------------------------
   20-  110 (131.74/102.93)	VSGPQ.PPPPGAPATQG......VRLSLLIEfLLQRTYHEITLLAELlprkTDMERKIEIVQFASRTRQLFVRLLAlVKWASNAGKVEKCAMISSFLD
  603-  694 (137.52/88.72)	VSGEQgDPEPKKPKRSGemcafnKELAHLVA.MCDTNMPFIGLRAEL....SNMEMANEGVQVEGDSSSHAIRLLK.IPPCKDVGEETRRALERSLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.27|      47|     351|     944|     992|       8
---------------------------------------------------------------------------
  944-  992 (80.52/52.29)	PG.....LKTFLNMFVDSNQdaRRRSVNEDDNPPSPVGVDMMDSLMNQLQAPQQ
 1293- 1344 (76.75/44.12)	PGtiavvLKAKMLFFLQLTQ..RVPAPQEPVTIIVPIVYDMATGLTQQADIPRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17392 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVQDTTAGRETRPGTKRKVSGEQGDPEPKKPKRSGE
2) NQDARRRSVNEDDNPPSPVGVDMMDSLMNQLQAPQQPQTMRGGPGGVYPPLTSPPPNYHANVTPSPSMLHTQSPGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGTSSQIMPTSMPPPRKLPQRPWA
585
957
620
1110










Molecular Recognition Features






MoRF SequenceStartStop




NANANA