<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17391

Description mediator of RNA polymerase II transcription subunit 26
SequenceMTTVPASPQQMKDRLLQAVDSQSNICNMVVVLEVIACLEKYPITKEALEETRLGKLINDVRKKTKDEDLAKRAKKLLRNWQKLIEPVSASVPGSTNGSSHPCRAEPFPADLSVSGKGLPEVKTRNDVHNTYSPKAEKSGSRKRRAEHKDTYHLPEKILKLSASDHCVTPPPTNGTAGSPEGLPDPGAVPSPDTSRTEHVENDKVNRIPVNAVKPRPSSPGMAKPPSTSSLIKVAVMQQQAKLEEGGEGYYQSRSPRSLTSSPRSLKQDSKRSSAYAAKGTPIPSPTSRDSPLSLSQPLSSPGPASYIEKLPQSSHKPTDVPPHYPTPDIPGSLGSPSLSPSLFLLQQNLELHRSPFDGSVAVSDDTDGSVVPNSEHKRRKYRSRDYSVNLDGQKLEDTTKPVRLKERRLTFDPVTGQIKPLVHKELSQTEISSTPEPTESRQRTEAPVPQPTATTSAPAPSPSPFHQTNWKELSRNEIIQSYLNLQSNLLTSSGVQAPSAHFFMSEYLKKEEQETKELRKTHVLQKYNIIGDLPGVSREVSSADLDRIHTQNWPGVNGCYDTQGTWYDWTECITLDPHGDESRLNILPYVCLD
Length593
PositionUnknown
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.05
Grand average of hydropathy-0.778
Instability index73.09
Isoelectric point8.58
Molecular weight65328.55
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17391
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     278.90|      77|      81|      61|     139|       1
---------------------------------------------------------------------------
   44-  120 (112.97/58.30)	.TKEA.LE....ETRLGKLINDVRKKTKDEDlAKR..AKKLLR....NWQKLIE...........PVS.AS....VPGSTNGSSHPCRAEPFPADLSVSGKGLPE
  122-  197 (113.50/56.35)	KTRND.VH....NTYSPKAEKSGSRKRRAEH..KD..TYHLPE....KILKL...............S.ASdhcvTPPPTNGTAGSPEGLPDPGAVPSPDTSRTE
  198-  281 (52.43/18.77)	HVENDkVNripvNAVKPRPSSPG........mAKPpsTSSLIKvavmQQQAKLEeggegyyqsrsPRSlTS....SPRSLKQDSK..RSSAYAA......KGTP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.76|      42|      44|     410|     453|       2
---------------------------------------------------------------------------
  410-  453 (66.43/38.74)	TFDPVTGQiKPLvH....KELSQTEISSTPEPTESRQRTEAPVPQPTA
  455-  500 (67.33/32.36)	TSAPAPSP.SPF.HqtnwKELSRNEIIQSYLNLQSNLLTSSGVQAPSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.73|      20|      37|     282|     301|       3
---------------------------------------------------------------------------
  282-  301 (36.77/16.25)	IPS..PTSRDSPLSLSQPLSSP
  303-  319 (22.34/ 6.93)	.....PASYIEKLPQSSHKPTD
  320-  340 (31.62/12.92)	VPPhyPTP.DIPGSLGSPSLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.87|      18|      22|     348|     368|       4
---------------------------------------------------------------------------
  359-  380 (24.11/20.29)	SVAVSDDTDGsvvpNSEHKRRK
  383-  401 (25.76/ 7.51)	SRDYSVNLDG...qKLEDTTKP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17391 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PVTGQIKPLVHKELSQTEISSTPEPTESRQRTEAPVPQPTATTSAPAPSPSPFHQTNW
2) RSPFDGSVAVSDDTDGSVVPNSEHKRRKYRSRDYSVNLDGQKLEDTTKPVRLKERRLTF
3) VSASVPGSTNGSSHPCRAEPFPADLSVSGKGLPEVKTRNDVHNTYSPKAEKSGSRKRRAEHKDTYHLPEKILKLSASDHCVTPPPTNGTAGSPEGLPDPGAVPSPDTSRTEHVENDKVNRIPVNAVKPRPSSPGMAKPPSTSSLIKVAVMQQQAKLEEGGEGYYQSRSPRSLTSSPRSLKQDSKRSSAYAAKGTPIPSPTSRDSPLSLSQPLSSPGPASYIEKLPQSSHKPTDVPPHYPTPDIPGSLGSPSLSPSLFLLQQNLE
413
353
87
470
411
350










Molecular Recognition Features






MoRF SequenceStartStop




NANANA