<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17386

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEVPGPDSDWRSPQFRQKVVAQIEDAMRKAGTANTTHKSGTDMENHVYIKAKTREEYLSLVARLIIHFRDIHRKALGGSDPMNALTNLTGVGGGPNTIGMGPRPPGAPVGGMGAMGPMQISQHAMAGVTGNPQTMGGPGQLSIQQMVQQQQQQQQQQQQTLQFQQFQQAQQAQQQQQQQQQQQQQQQQQQQFQQLRVQQLQQQQQQAQNQQLQNQQMHQTRMQQQLILQQQQQQHQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMVQQQQQVQQAQMPPHSQQQPGMVPQSLAGQMTSAQHVPINSLSQQPQLKFPQSRATLPMQQAAAAAASAAVPGQMVRPPQNPIRLPRAPLNTSVPPPNMATPPTGIAGQTPQVQHTMMSSPSPVQVPTPQMPPPPQPSPQPPSSQPNSASSGPTPSPGGFQPSPSPQPSPSPASSRTPQPSHGVASPGPLNTPVNPSLVMSPAGATSLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPTKQQYLCQPLLDAVMADIRSPFFNHSLYRTFAPAMSAIHGPPIMGPNISGRKRKYEEDERQTIPNILQGEVARLDVKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSVPAEYPDQSPHWANDGDQYGANSFLQTVHRNLTSKLLQLPDKHSVTELLNTWAQSVRQACLSAA
Length757
PositionTail
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.03
Grand average of hydropathy-0.770
Instability index72.84
Isoelectric point9.53
Molecular weight82839.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17386
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     201.97|      23|      23|     236|     258|       1
---------------------------------------------------------------------------
  149-  170 (36.40/ 6.96)	QQQQQQQQQQQTlQFQ.QFQ.QAQ
  171-  193 (47.04/11.19)	QAQQQQQQQQQQ.QQQQQQQQQFQ
  194-  215 (37.11/ 7.24)	QLRVQQLQQQQQ.QAQNQ.QLQNQ
  236-  258 (42.95/ 9.57)	QAQAQAQAQAQA.QAQAQAQAQAQ
  274-  297 (38.46/ 7.78)	QAQAQAQAQAQSiQQMVQQQQQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     163.10|      29|      29|     421|     449|       2
---------------------------------------------------------------------------
  359-  383 (34.79/ 7.81)	A..VPGQM.V.RPPQNPIRLPRAPLNTS....V
  384-  411 (43.04/11.57)	P..PPNMA.T.PPTGIAGQTPQVQHTMMSS.PS
  412-  443 (51.55/15.45)	PvqVPTPQmP.PPPQPSPQPPSSQPNSASSGPT
  444-  468 (33.72/ 7.32)	P..SPGGFqPsPSPQPSPSPASSR......TPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.62|      26|      35|      76|     102|       3
---------------------------------------------------------------------------
   76-  102 (45.93/28.82)	LGGSDPMN.ALTNLTGVGGGPNTIGmGP
  112-  138 (48.69/26.13)	MGAMGPMQiSQHAMAGVTGNPQTMG.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.79|      26|      26|     533|     558|       4
---------------------------------------------------------------------------
  533-  558 (43.34/24.41)	LSKMKSLLNILTDPNTRCPLKTLQKC
  562-  587 (44.44/25.24)	LEKLKNDMAVPTPPPPPVPTKQQYLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.84|      24|      25|     299|     323|       5
---------------------------------------------------------------------------
  299-  322 (48.04/16.87)	AQ.MPPHS.QQQPGM.VPQSLAG.QMTS
  323-  350 (28.80/ 9.17)	AQhVPINSlSQQPQLkFPQSRATlPMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.75|      19|     587|       9|      27|       6
---------------------------------------------------------------------------
    9-   27 (35.46/24.81)	DWRSPQFRQKVVAQIEDAM
  597-  615 (36.29/25.58)	DIRSPFFNHSLYRTFAPAM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17386 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALGGSDPMNALTNLTGVGGGPNTIGMGPRPPGAPVGGMGAMGPMQISQHAMAGVTGNPQTMGGPGQLSIQQMVQ
2) AQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQ
3) IEPLRRMINKIDKNEDRKKDLSKMKSLLNI
4) MEVPGPDSDWRSPQFRQKVVAQIEDAMRKAGTANTTHKSGTDMENHVY
5) QQQQQVQQAQMPPHSQQQPGMVPQSLAGQMTSAQHVPINSLSQQPQLKFPQSRATLPMQQAAAAAASAAVPGQMVRPPQNPIRLPRAPLNTSVPPPNMATPPTGIAGQTPQVQHTMMSSPSPVQVPTPQMPPPPQPSPQPPSSQPNSASSGPTPSPGGFQPSPSPQPSPSPASSRTPQPSHGVASPGPLNTPVNPSLVMSPAGATSLEDQQYMEKLKQLSK
75
239
513
1
291
148
278
542
48
511










Molecular Recognition Features






MoRF SequenceStartStop




NANANA