<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17385

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMFQAAAATQQQACLFLLAVKEGSFVLLQQKSRREKLIRPWRFLDRTATGGARSFGRKSWLRCEKRCFFLRASAQLLEDAMRKAGTANTTHKSGTDMENHVYIKAKTREEYLSLVARLIIHFRDIHRKALGGSDPMNALTNLTGVGGGPNTIGMGPRPPGAPVGGMGAMGPMQISQHAMAGVTGNPQTMGGPGQLSIQQMVQQQQQQQQQQQQTLQFQQFQQAQQAQQQQQQQQQQQQQQQQQQQFQQLRVQQLQQQQQQAQNQQLQNQMHQTRMQQQLILQQQQQQHQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMVQQQQQVQQAQMPPHSQQQPGMVPQSLAGQMTSAQHVPINSLSQQPQLKFPQSRATLPMQQAAAAAASAAVPGQMVRPPQNPIRLPRAPLNTSVPPPNMATPPTGIAGQTPQVQHTMMSSPSPVQVPTPQMPPPPQPSPQPPSSQPNSASSGPTPSPGGFQPSPSPQPSPSPASSRTPQPSHGVASPGPLNTPVNPSLVMSPAGATSLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPTKQQYLCQPLLDAVMADIRSPFFNHSLYRTFAPAMSAIHGPPIMGPNISGRKRKYEEDERQTIPNILQGEVARLDVKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSVPAEYPDQSPHWANDGDQYGANSFLQTVHRNLTSKLLQLPDKHSVTELLNTWAQSVRQACLSAA
Length809
PositionTail
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.04
Grand average of hydropathy-0.709
Instability index70.51
Isoelectric point9.85
Molecular weight88834.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17385
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     159.91|      23|      23|     288|     310|       1
---------------------------------------------------------------------------
  206-  225 (36.81/ 8.34)	QQQQQQQT.L.QFQ.QFQ.QAQ.QA
  226-  248 (45.71/12.35)	QQQQQQQQQQ.QQQQQQQQQFQ.QL
  290-  313 (39.20/ 9.42)	QAQAQAQAQA.QAQAQAQAQAQaQA
  328-  351 (38.18/ 8.96)	QAQAQAQAQSiQQMVQQQQQVQ.QA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.19|      23|      23|     477|     499|       2
---------------------------------------------------------------------------
  404-  426 (28.19/ 6.10)	AAAAASAAVPGQM..VRPP......QN.PIRL
  427-  455 (29.63/ 6.85)	PRAPLNTSVPPPN..MATPptgiagQT.PQVQ
  487-  512 (35.38/ 9.82)	PNSASSGPTPSPGgfQPSP......SPqPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.62|      26|      35|     129|     155|       4
---------------------------------------------------------------------------
  129-  155 (45.93/30.69)	LGGSDPMN.ALTNLTGVGGGPNTIGmGP
  165-  191 (48.69/27.84)	MGAMGPMQiSQHAMAGVTGNPQTMG.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.20|      13|     153|     467|     481|       5
---------------------------------------------------------------------------
  467-  481 (26.72/11.92)	VPTPqmPPPPQPSPQ
  623-  635 (27.48/ 7.30)	VPTP..PPPPVPTKQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17385 with Med15 domain of Kingdom Metazoa
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