<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17384

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMFQAAAATQQQACLFLLAVKEGSFVLLQQKSRREKLIRPWRFLDRTATGGARSFGRKSWLRCEKRCFFLRASAQLLEDAMRKAGTANTTHKSGTDMENHVYIKAKTREEYLSLVARLIIHFRDIHRKALGGSDPMNALTNLTGVGGGPNTIGMGPRPPGAPVGGMGAMGPMQISQHAMAGVTGNPQTMGGPGQLSIQQMVQQQQQQQQQQQQTLQFQQFQQAQQAQQQQQQQQQQQQQQQQQQQFQQLRVQQLQQQQQQAQNQQLQNQQMHQTRMQQQLILQQQQQQHQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMVQQQQQVQQAQMPPHSQQQPGMVPQSLAGQMTSAQHVPINSLSQQPQLKFPSRATLPMQQAAAAAASAAVPGQMVRPPQNPIRLPRAPLNTSVPPPNMATPPTGIAGQTPQVQHTMMSSPSPVQVPTPQMPPPPQPSPQPPSSQPNSASSGPTPSPGGFQPSPSPQPSPSPASSRTPQPSHGVASPGPLNTPVNPSLVMSPAGATSLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPTKQQYLCQPLLDAVMADIRSPFFNHSLYRTFAPAMSAIHGPPIMGPNISGRKRKYEEDERQTIPNILQGEVARLDVKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSVPAEYPDQSPHWANDGDQYGANSFLQTVHRNLTSKLLQLPDKHSVTELLNTWAQSVRQACLSAA
Length809
PositionTail
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.04
Grand average of hydropathy-0.709
Instability index70.20
Isoelectric point9.85
Molecular weight88834.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17384
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     227.63|      23|      23|     289|     311|       1
---------------------------------------------------------------------------
  193-  214 (35.83/ 7.54)	QLS..IQQMVQQQ.QQQQQQQQQT.L
  215-  235 (42.26/10.29)	QFQ...QFQ.QAQ.QAQQQQQQQQQQ
  255-  275 (36.74/ 7.93)	Q....QQQQAQNQ.QLQNQQMHQTRM
  276-  300 (34.24/ 6.86)	QQQliLQ.QQQQQhQAQAQAQAQAQA
  301-  324 (38.17/ 8.54)	QAQ..AQAQAQAQaQAQAQAQAQAQA
  340-  362 (40.39/ 9.49)	QQM..VQQQQQVQ.QAQMPPHSQQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     206.05|      29|      29|     473|     501|       2
---------------------------------------------------------------------------
  385-  416 (34.10/ 8.06)	S.QQPQlkfPSRATLPMQQAAAAAASAA..VPGQM
  417-  441 (35.92/ 8.93)	V.RPPQ...NPIRLPRAPLNTS....VP..PPNMA
  442-  471 (39.01/10.40)	T.PPTG...IAGQTPQVQHTMMSS.PSPvqVPTPQ
  473-  501 (60.77/20.74)	P.PPPQ...PSPQPPSSQPNSASSGPTP..SPGGF
  503-  526 (36.25/ 9.08)	PsPSPQ...PSPSPASSR......TPQP..SHGVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.58|      27|      28|     585|     611|       3
---------------------------------------------------------------------------
  555-  579 (38.62/19.15)	MEKLKQLSKYI.EPLRRM.INKIDKNE
  585-  611 (45.19/23.71)	LSKMKSLLNILTDPNTRCPLKTLQKCE
  614-  640 (47.77/25.50)	LEKLKNDMAVPTPPPPPVPTKQQYLCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.62|      26|      34|     129|     155|       4
---------------------------------------------------------------------------
  129-  155 (45.93/34.08)	LGGSDPMN.ALTNLTGVGGGPNTIGmGP
  165-  191 (48.69/30.91)	MGAMGPMQiSQHAMAGVTGNPQTMG.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.96|      13|     118|     534|     548|       5
---------------------------------------------------------------------------
  536-  548 (23.55/13.68)	NPSLVMSPAGATS
  656-  668 (23.41/ 7.06)	NHSLYRTFAPAMS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17384 with Med15 domain of Kingdom Metazoa
Unable to open file!