<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17381

Description mediator of RNA polymerase II transcription subunit 25
SequenceMEPPSNPGSSQVADVVFVIEGTANLGPYFESLRKNYILPAIEFFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFIKMREQIGQTHKVCVLLCNSPPYLLPAVESVTYTGLTADSLVKFIRDRGIHFSVIAPRKLPALRALFEMGSPVTGAVEPHPDYSQDPFHMVLVRGISLPVSTGGGPGPLKPVLPLQALPGNQSVAGPPQVTPPINPAHPYQNTPPMSAAFVAAQMAVEAANNQKNRFPGMVTPGQPFSSQPGIPPVQMKPPQPSISTVTTATQPPMMQQPVPPNPQQPVPPPGQPASNQPTQPQPPQPAPNQPTAPSAPSNMGGVPGPPGNANLIAQPQPNKVVAWTGVLEWQEKPKASSMDSTKLTRSLPCQVHVNQGENLNTEQWPQKLIMQLIPQQLLTTLGHLFRNSRMVQFLFTNKDPDSLRGLYRIMANGFAGCVHFPHTTSPCEVRVLMLLYSSKKKIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRAQMGGGGGPMQPGQVPPNQNFLNRAPGSIPVSHGSVQQQSVVVGMPPVSQVSIMEEQQRQNNMMAMRAAGPSNQQPAVSVAPPNQVTQSGQAQPQGSILRLPNPGANPQLRSLLLSQQQPQSAVSHMPNMMSHQGLGPQLVHSTPGGGPQMQGQWRQPMTGQILMSGGQRGPVPQPGMPQVSGVIDDEILLDLI
Length744
PositionUnknown
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.06
Grand average of hydropathy-0.289
Instability index53.85
Isoelectric point7.68
Molecular weight79614.17
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17381
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     215.60|      33|      34|     328|     360|       1
---------------------------------------------------------------------------
  293-  329 (40.91/ 9.31)	PGMVTPGQ......PFSSQ..P..gI..............P.PvqmkPPQPSiSTVTTATQ..........P
  330-  363 (68.35/21.05)	PMMQQPVP......PNPQQ..P...V..............P.P....PGQPA.SNQPTQPQP.......pQP
  364-  395 (33.26/ 6.04)	APNQPTAP......SAPSNmgG...V..............PgP....PGN...ANLIAQPQP..........
  562-  613 (34.10/ 6.40)	PGQVPPNQnflnraPGSI...P...VshgsvqqqsvvvgmP.P....VSQVS.IMEEQQRQN........NM
  614-  654 (38.98/ 8.48)	MAMRAAGP......SN.QQ..PavsV..............A.P....P.NQ..VTQSGQAQPqgsilrlpNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.47|      27|      55|     185|     212|       2
---------------------------------------------------------------------------
  185-  212 (47.24/21.91)	LPALRALFEM.GSP.VTGAVEP.HPdYSQDP
  223-  239 (32.67/10.56)	LPVSTG.....GGP...GPLKP.VL.....P
  240-  269 (41.56/15.37)	LQALPGNQSVaGPPqVTPPINPaHP.YQNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.10|      22|      28|     676|     703|       3
---------------------------------------------------------------------------
  676-  703 (37.18/23.36)	HMP....NMMS..HQGLGPQlvhstPgGGPQMQG
  706-  733 (33.92/10.52)	RQPmtgqILMSggQRGPVPQ.....P.GMPQVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.89|      23|      24|     459|     482|       4
---------------------------------------------------------------------------
  459-  482 (37.20/28.21)	LGHLFRN..SRMVQFLFTNkDPDSLR
  484-  508 (39.70/25.34)	LYRIMANgfAGCVHFPHTT.SPCEVR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17381 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AWTGVLEWQEKPKASSMDSTKLTRSLPCQVHVNQGEN
2) GPLKPVLPLQALPGNQSVAGPPQVTPPINPAHPYQNTPPMSAAFVAAQMAVEAANNQKNRFPGMVTPGQPFSSQPGIPPVQMKPPQPSISTVTTATQPPMMQQPVPPNPQQPVPPPGQPASNQPTQPQPPQPAPNQPTAPSAPSNMGGVPGPPGNANLIAQPQP
3) HKQVQQHRAQMGGGGGPMQPGQVPPNQNFLNRAPGSIP
4) PVSQVSIMEEQQRQNNMMAMRAAGPSNQQPAVSVAPPNQVTQSGQAQPQGSILRLPNPGANPQLRSLLLSQQQPQSAVSHMPNMMSHQGLGPQLVHSTPGGGPQMQGQWRQPMTGQILMSGGQRGPVPQPGMPQVS
400
232
543
597
436
395
580
732










Molecular Recognition Features






MoRF SequenceStartStop




NANANA