<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17374

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNIFCLADLTGIKWRRFVWQGPTSSPILFPVTEEDPILCSFSRCLAADVLSVWRRHQTRGRRELWLFWWGDDPSFAELIHNELSSEEDGEWDSGLSYECRTLLFKAIHNLLERCLMNRGFVRIGKWFVKPYQKEEKTINKSEHLSCAFTFFVHGDSNVCTSVEIAQHQPLQRLGEEHLSLAQQSSSPLQVILSPYGLNGTLTGQAFKMSDHPTQKLIEEWRQFYPICPNPKEVQEDKMDDADWEDDSLAAVEVLVAGVRMVYPSCLVLLPLSDLPAVVPQGSANTLGSQCGAQQGQATHRDSAISSVTLTPPTSPEEAHTDYQPAHRWLKLSSASDCYNSNNTLHGGKIPRRLAGQMVESVWQEYNINRTGNKRKLTNLTNGTCDEESGNTGLWDFVESTCRPTCSCSRHKNQKQRSGSTSGHPPSSGQPAQPAPKHKLGEKLEKAEKQQRRPQTPFHHRNSVSEEQXLEPPNPRLCSRPQEEGSYPGLHHLDMVPPKAPTLHSHGPPADPAGSPPPPPLSPHPCDRAESDLIPGTTKNPSTPAHQAFYPPSVEPCLLPQKSSSSEPQMESAPMPLSFPSAFXENLEPATFIGSAVNPSEDSSYNPWKYFNLPRKKNSSFSPPQLPVDKTRDDCGRGADSVVSVTEVMCDSSRPLKVSQDVVKTYSQRRNSHLVSSSGDREHSEEPDPYAFEEDEEDNFTEKKDKSGTEKDGSKKQKLDEATGTSADDGQGPSGSKPSASTSLFHENDLAVSYSDLEKIFNSDEDDPASIIKRAGVGIEDDTNCKKTKPTLLDRLPCVSPVDLHKMFPTPPSLEHQGYSPIHSGSNDSLETGSSLTVLDVSQLNSHFKVEVEEGFCSPKPSEIKDFSFVYKPETCQSITGCSMYAPLKTLPSQCLSPIKLPENCVYTTSWTMGKMELIPPVSGVSLLTKDSNVPSVDPDYSQTYTPQTHTPFMSSSAPPSNSGAGILPSPATPRFSVPTPRTPRTPRTPRGPSSVQGSLKYDNSDLYSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCVCVCNMNIRGSDVGVYLKDNGEAQYPCTCGFSAVTNRRFGQSAGLFLEDELDVVGRGSDASRDTERCFEELRGSLKEKPPDELILLLQDRCTNPFAPFAGVEYSKLNSALTSFLRVEERDCYNDCYMALEHGRQFMDNMSGGKVDETLVKSTSLHQWPKCKSADMSKLFSQDVLRVLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDVGYVVVCPENEALLRGARTFFKDLGVMYEACQLGQHRPICKSHPEGILAVGTTEGRSMTEQPLSDWFLKMAAREGNNEAFNKLKLFAQVCRYDLAPHLSELPLDSSLLCHRNPTTAPSFSSSSLSQTSNSSSNSSGLQSANASSAGSAQTAQVNSTPPSSSSSSSSSSGSQTIGTLASGKPSSYLPFGSGVLQGGATQNEPQSNSQGAGSLAENGSSQPQGSTETPESTMERDKVGKPTDGESHAISYPPAIVVYIVDPFSYEDADREVHSSSYTLGLLRCYMEMLPFLPAHIRNAISVQIVPCQYLLQPVHSGERHVYSQHLKSLAFSVYTHCRRPLPGSTNFKALTGFGPGLAIDMALKNPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDQHGELLESCIISIDVPNRARRKKGSARRVGLQKLWEWCVGLVQVTSLPWRVVIGRLGRMGHGELRDWSILLSRRNLQSLSKRLKETCRMCGISAADTPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAMVQVNTNTAEPIDISFNPINDGSDGMALFDLFDNDMDHDMDPDLINILPNSPTTSPVHSPGSHYHQGGDGSKGQSADRMESHEEALNILQQPMALGYFISTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQSDEFLHSKHSHPLDSNHTSDVLRFVLEQYNALSWLTCNPATQDRRSCLPVHFVVLTQIYNFIMNML
Length2121
PositionMiddle
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.469
Instability index57.10
Isoelectric point5.65
Molecular weight233143.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17374
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.26|      32|      36|     524|     557|       1
---------------------------------------------------------------------------
  463-  500 (30.63/ 7.84)	EKQ.....QRRPQ...............tpfhhrnsvseeqxlEPP..NPRLCSRPQEEG
  507-  544 (51.56/17.93)	HLDMVP.....PKaptlhshgpPADPAG...............SPP..PPPLSPHPCDRA
  545-  581 (42.08/17.23)	ESDLIPgtTKNPS........tPAHQAF...............YPPsvEPCLLPQKSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     168.51|      36|      36|     950|     985|       2
---------------------------------------------------------------------------
  874-  905 (36.17/12.96)	......PK......PSEIKDF........SFVYKPET.CQ.SITGCSmyAPLK.T
  938-  977 (55.15/24.11)	SGVSLL..tkdsnvPSVDPDY........SQTYTPQT.HT.PFMSSS..APPS.N
  978- 1016 (30.54/ 9.66)	SGAGILPS.............patprfsvPTPRTPRTpRT.PRGPSS..VQGSlK
 1017- 1050 (46.65/19.11)	YDNSDLYS......PASTP...........STCRPLS.SVePATVPS..IPEA.H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.16|      27|      36|      30|      64|       3
---------------------------------------------------------------------------
   21-   57 (36.59/31.28)	CLA.DltgikWRRFVWQGPtSSPILFpVTEEDPilcSF
   60-   91 (50.57/23.62)	CLAaD.vlsvWRRHQTRGR.RELWLF.WWGDDP...SF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.42|      17|      37|    1466|    1482|       4
---------------------------------------------------------------------------
 1466- 1482 (27.53/13.59)	SNSSSNSSG.LQSANASS
 1487- 1503 (25.99/12.32)	QTAQVNSTP.PSSSSSSS
 1504- 1521 (22.90/ 9.76)	SSSGSQTIGtLASGKPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.60|      12|      37|     232|     243|       5
---------------------------------------------------------------------------
  232-  243 (25.48/16.33)	LIEEWRQFYPIC
  270-  281 (23.11/14.05)	LVAGVRMVYPSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.91|      32|     263|    1072|    1105|       7
---------------------------------------------------------------------------
 1072- 1105 (60.87/43.37)	DSCCVCVCNMN...IRGSDvgVYLKDNGEAQYPCTCG
 1338- 1372 (55.03/32.81)	DVGYVVVCPENealLRGAR..TFFKDLGVMYEACQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.44|      44|     263|    1286|    1333|       8
---------------------------------------------------------------------------
 1286- 1333 (75.68/44.43)	MAGRGS...YGTDESPEPlPIPTFLVGYEYD...FVVLSPfglPYWEKLLLDPF
 1549- 1598 (68.76/31.05)	LAENGSsqpQGSTETPES.TMERDKVGKPTDgesHAISYP...PAIVVYIVDPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.90|      34|      37|     372|     406|       9
---------------------------------------------------------------------------
  372-  406 (54.72/35.93)	QMVESVWQEY.NINRTGNKRKLTNLTNGTcDEESGN
  411-  445 (58.17/33.02)	DFVESTCRPTcSCSRHKNQKQRSGSTSGH.PPSSGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     282.38|      78|    1153|     773|     855|      10
---------------------------------------------------------------------------
  699-  772 (98.08/43.21)	SEEPDPYAFEEDEEDNFtekKDKSGTEKdgSKKQKLDEATGTSADDGQGPSGSKPS...ASTSLFH..ENDLAVSY.SDL....
  778-  855 (137.52/73.49)	SDEDDPASIIKRAGVGI...EDDTNCKK..TKPTLLDRLPCVSPVDLHKMFPTPPSLEHQGYSPIHSGSNDSLETG.SSLTVLD
 1969- 2007 (46.77/16.95)	.......................................PTTSPV..H....SPGSHYHQGGDGSKGQSADRMESHeEALNILQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.63|      44|     601|    1400|    1451|      11
---------------------------------------------------------------------------
 1400- 1451 (68.96/53.89)	PLSDWFLKMAARegnneAFNKLKLFAQVcryDLAPHLSELPLDSSLLC.HRNP
 2023- 2067 (82.66/44.74)	PLPDWFWSACPQ.....AQNQCPLFLKA...SLHLHVSSVQSDEFLHSkHSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.19|      12|     263|     181|     192|      12
---------------------------------------------------------------------------
  181-  192 (22.59/13.14)	AQHQPLQRLGEE
  447-  458 (22.60/13.15)	AQPAPKHKLGEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.10|      26|      29|    1143|    1168|      14
---------------------------------------------------------------------------
 1143- 1168 (45.06/31.90)	FEELRGSLKEKPPDEL..ILLLQDR.CTN
 1170- 1198 (37.04/24.64)	FAPFAGVEYSKLNSALtsFLRVEERdCYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.59|      23|      31|     635|     659|      17
---------------------------------------------------------------------------
  635-  659 (35.83/29.28)	SFSPPQLPVD..KTRDDcgRGADSVVS
  667-  691 (34.77/19.95)	SSRPLKVSQDvvKTYSQ..RRNSHLVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.08|      35|    1318|     592|     628|      22
---------------------------------------------------------------------------
  592-  628 (56.87/35.58)	LSFP.SAFxE.NLEPATFIGSAVNPSEDSSyNPWKYFNL
 1911- 1948 (51.21/27.06)	LVFPtSAMvQvNTNTAEPIDISFNPINDGS.DGMALFDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17374 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSRHKNQKQRSGSTSGHPPSSGQPAQPAPKHKLGEKLEKAEKQQRRPQTPFHHRNSVSEEQXLEPPNPRLCSRPQEEGSYPGLHHLDMVPPKAPTLHSHGPPADPAGSPPPPPLSPHPCDRAESDLIPGTTKNPSTPAHQAFYPPSVEPCLLPQKSSSSEPQMESAPMPLSFPS
2) DPDLINILPNSPTTSPVHSPGSHYHQGGDGSKGQSADRMESHEEA
3) FGSGVLQGGATQNEPQSNSQGAGSLAENGSSQPQGSTETPESTMERDKVGKPTDGES
4) LKVSQDVVKTYSQRRNSHLVSSSGDREHSEEPDPYAFEEDEEDNFTEKKDKSGTEKDGSKKQKLDEATGTSADDGQGPSGSKPSASTSLFHEN
5) LLTKDSNVPSVDPDYSQTYTPQTHTPFMSSSAPPSNSGAGILPSPATPRFSVPTPRTPRTPRTPRGPSSVQGSLKYDNS
6) SANTLGSQCGAQQGQATHRDSAISSVTLTPPTSPEEAHTDYQPA
7) SFSSSSLSQTSNSSSNSSGLQSANASSAGSAQTAQVNSTPPSSSSSSSSSSGSQTIGTLASG
8) SSFSPPQLPVDKTRDDCGRGADSVVSVTEVMCD
423
1958
1525
671
942
298
1456
634
596
2002
1581
763
1020
341
1517
666










Molecular Recognition Features






MoRF SequenceStartStop




NANANA