<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17374
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MSSCFVPNGASLEDCHSNIFCLADLTGIKWRRFVWQGPTSSPILFPVTEEDPILCSFSRCLAADVLSVWRRHQTRGRRELWLFWWGDDPSFAELIHNELSSEEDGEWDSGLSYECRTLLFKAIHNLLERCLMNRGFVRIGKWFVKPYQKEEKTINKSEHLSCAFTFFVHGDSNVCTSVEIAQHQPLQRLGEEHLSLAQQSSSPLQVILSPYGLNGTLTGQAFKMSDHPTQKLIEEWRQFYPICPNPKEVQEDKMDDADWEDDSLAAVEVLVAGVRMVYPSCLVLLPLSDLPAVVPQGSANTLGSQCGAQQGQATHRDSAISSVTLTPPTSPEEAHTDYQPAHRWLKLSSASDCYNSNNTLHGGKIPRRLAGQMVESVWQEYNINRTGNKRKLTNLTNGTCDEESGNTGLWDFVESTCRPTCSCSRHKNQKQRSGSTSGHPPSSGQPAQPAPKHKLGEKLEKAEKQQRRPQTPFHHRNSVSEEQXLEPPNPRLCSRPQEEGSYPGLHHLDMVPPKAPTLHSHGPPADPAGSPPPPPLSPHPCDRAESDLIPGTTKNPSTPAHQAFYPPSVEPCLLPQKSSSSEPQMESAPMPLSFPSAFXENLEPATFIGSAVNPSEDSSYNPWKYFNLPRKKNSSFSPPQLPVDKTRDDCGRGADSVVSVTEVMCDSSRPLKVSQDVVKTYSQRRNSHLVSSSGDREHSEEPDPYAFEEDEEDNFTEKKDKSGTEKDGSKKQKLDEATGTSADDGQGPSGSKPSASTSLFHENDLAVSYSDLEKIFNSDEDDPASIIKRAGVGIEDDTNCKKTKPTLLDRLPCVSPVDLHKMFPTPPSLEHQGYSPIHSGSNDSLETGSSLTVLDVSQLNSHFKVEVEEGFCSPKPSEIKDFSFVYKPETCQSITGCSMYAPLKTLPSQCLSPIKLPENCVYTTSWTMGKMELIPPVSGVSLLTKDSNVPSVDPDYSQTYTPQTHTPFMSSSAPPSNSGAGILPSPATPRFSVPTPRTPRTPRTPRGPSSVQGSLKYDNSDLYSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCVCVCNMNIRGSDVGVYLKDNGEAQYPCTCGFSAVTNRRFGQSAGLFLEDELDVVGRGSDASRDTERCFEELRGSLKEKPPDELILLLQDRCTNPFAPFAGVEYSKLNSALTSFLRVEERDCYNDCYMALEHGRQFMDNMSGGKVDETLVKSTSLHQWPKCKSADMSKLFSQDVLRVLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDVGYVVVCPENEALLRGARTFFKDLGVMYEACQLGQHRPICKSHPEGILAVGTTEGRSMTEQPLSDWFLKMAAREGNNEAFNKLKLFAQVCRYDLAPHLSELPLDSSLLCHRNPTTAPSFSSSSLSQTSNSSSNSSGLQSANASSAGSAQTAQVNSTPPSSSSSSSSSSGSQTIGTLASGKPSSYLPFGSGVLQGGATQNEPQSNSQGAGSLAENGSSQPQGSTETPESTMERDKVGKPTDGESHAISYPPAIVVYIVDPFSYEDADREVHSSSYTLGLLRCYMEMLPFLPAHIRNAISVQIVPCQYLLQPVHSGERHVYSQHLKSLAFSVYTHCRRPLPGSTNFKALTGFGPGLAIDMALKNPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDQHGELLESCIISIDVPNRARRKKGSARRVGLQKLWEWCVGLVQVTSLPWRVVIGRLGRMGHGELRDWSILLSRRNLQSLSKRLKETCRMCGISAADTPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAMVQVNTNTAEPIDISFNPINDGSDGMALFDLFDNDMDHDMDPDLINILPNSPTTSPVHSPGSHYHQGGDGSKGQSADRMESHEEALNILQQPMALGYFISTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQSDEFLHSKHSHPLDSNHTSDVLRFVLEQYNALSWLTCNPATQDRRSCLPVHFVVLTQIYNFIMNML |
Length | 2121 |
Position | Middle |
Organism | Austrofundulus limnaeus |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae>
Austrofundulus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.469 |
Instability index | 57.10 |
Isoelectric point | 5.65 |
Molecular weight | 233143.13 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP17374
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 124.26| 32| 36| 524| 557| 1
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463- 500 (30.63/ 7.84) EKQ.....QRRPQ...............tpfhhrnsvseeqxlEPP..NPRLCSRPQEEG
507- 544 (51.56/17.93) HLDMVP.....PKaptlhshgpPADPAG...............SPP..PPPLSPHPCDRA
545- 581 (42.08/17.23) ESDLIPgtTKNPS........tPAHQAF...............YPPsvEPCLLPQKSSSS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 168.51| 36| 36| 950| 985| 2
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874- 905 (36.17/12.96) ......PK......PSEIKDF........SFVYKPET.CQ.SITGCSmyAPLK.T
938- 977 (55.15/24.11) SGVSLL..tkdsnvPSVDPDY........SQTYTPQT.HT.PFMSSS..APPS.N
978- 1016 (30.54/ 9.66) SGAGILPS.............patprfsvPTPRTPRTpRT.PRGPSS..VQGSlK
1017- 1050 (46.65/19.11) YDNSDLYS......PASTP...........STCRPLS.SVePATVPS..IPEA.H
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.16| 27| 36| 30| 64| 3
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21- 57 (36.59/31.28) CLA.DltgikWRRFVWQGPtSSPILFpVTEEDPilcSF
60- 91 (50.57/23.62) CLAaD.vlsvWRRHQTRGR.RELWLF.WWGDDP...SF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 76.42| 17| 37| 1466| 1482| 4
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1466- 1482 (27.53/13.59) SNSSSNSSG.LQSANASS
1487- 1503 (25.99/12.32) QTAQVNSTP.PSSSSSSS
1504- 1521 (22.90/ 9.76) SSSGSQTIGtLASGKPSS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.60| 12| 37| 232| 243| 5
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232- 243 (25.48/16.33) LIEEWRQFYPIC
270- 281 (23.11/14.05) LVAGVRMVYPSC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 115.91| 32| 263| 1072| 1105| 7
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1072- 1105 (60.87/43.37) DSCCVCVCNMN...IRGSDvgVYLKDNGEAQYPCTCG
1338- 1372 (55.03/32.81) DVGYVVVCPENealLRGAR..TFFKDLGVMYEACQLG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 144.44| 44| 263| 1286| 1333| 8
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1286- 1333 (75.68/44.43) MAGRGS...YGTDESPEPlPIPTFLVGYEYD...FVVLSPfglPYWEKLLLDPF
1549- 1598 (68.76/31.05) LAENGSsqpQGSTETPES.TMERDKVGKPTDgesHAISYP...PAIVVYIVDPF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 112.90| 34| 37| 372| 406| 9
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372- 406 (54.72/35.93) QMVESVWQEY.NINRTGNKRKLTNLTNGTcDEESGN
411- 445 (58.17/33.02) DFVESTCRPTcSCSRHKNQKQRSGSTSGH.PPSSGQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 282.38| 78| 1153| 773| 855| 10
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699- 772 (98.08/43.21) SEEPDPYAFEEDEEDNFtekKDKSGTEKdgSKKQKLDEATGTSADDGQGPSGSKPS...ASTSLFH..ENDLAVSY.SDL....
778- 855 (137.52/73.49) SDEDDPASIIKRAGVGI...EDDTNCKK..TKPTLLDRLPCVSPVDLHKMFPTPPSLEHQGYSPIHSGSNDSLETG.SSLTVLD
1969- 2007 (46.77/16.95) .......................................PTTSPV..H....SPGSHYHQGGDGSKGQSADRMESHeEALNILQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 151.63| 44| 601| 1400| 1451| 11
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1400- 1451 (68.96/53.89) PLSDWFLKMAARegnneAFNKLKLFAQVcryDLAPHLSELPLDSSLLC.HRNP
2023- 2067 (82.66/44.74) PLPDWFWSACPQ.....AQNQCPLFLKA...SLHLHVSSVQSDEFLHSkHSHP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.19| 12| 263| 181| 192| 12
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181- 192 (22.59/13.14) AQHQPLQRLGEE
447- 458 (22.60/13.15) AQPAPKHKLGEK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.10| 26| 29| 1143| 1168| 14
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1143- 1168 (45.06/31.90) FEELRGSLKEKPPDEL..ILLLQDR.CTN
1170- 1198 (37.04/24.64) FAPFAGVEYSKLNSALtsFLRVEERdCYN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 70.59| 23| 31| 635| 659| 17
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635- 659 (35.83/29.28) SFSPPQLPVD..KTRDDcgRGADSVVS
667- 691 (34.77/19.95) SSRPLKVSQDvvKTYSQ..RRNSHLVS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 108.08| 35| 1318| 592| 628| 22
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592- 628 (56.87/35.58) LSFP.SAFxE.NLEPATFIGSAVNPSEDSSyNPWKYFNL
1911- 1948 (51.21/27.06) LVFPtSAMvQvNTNTAEPIDISFNPINDGS.DGMALFDL
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