<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17361

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMATGPVVSLQTGSPARELPISFQQVGNQTLGDRVKSEDVTEAEKQSRMAALLERLHAKHNXSRPWQETSKVVRQAMEKRGVVNTAGHQLLLNCLETLQRALKVSSLSSMTDRLESIARQNMLGSHLSPSGTECYITSDMFYVEVQLDTSGQLLDVKVAHQGENPTSCPELIQHLSEKNFEEFSKHLKGLVDLYKLPGDNKLKTKMYIALQSLELDLTKMMQMFRLATNANTVETILHGSVGLLTARSGGHLVSLHCYVSPYDIFEVETGSQLNVSDSNVPSSLGISVSVTIEGTSSVYKLPIAPLITGSHPIDNKGTPSFSTVTNSNCVDLPACFFLKMNRPMPFSLSFIQRISSATSISVFETSPSLSPLYQLIVQSXLQLLEESSSVPPSLHNMHFYSILPDQHHCYFLNGDAPVQDGHSLQGAMVSKIPFRHPAQVPLLLDIIRHQAAYNTLIGSCVKRTSVKEDSASLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVICNLYKGPSDALICTDEFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAQTVETMVKNNPPPSGSPTYNMTIGDGTNPIGLTGITEGNTPTGVGPPGGPNFTGPITTLFGISRADRQAQGVECVTPGGVAGQQQLQQQQQSQGHTDDYSKVTQNPILTSLLQITGNVGSSPSSQNAPQPHQTPPPTSSPASNTKNHPMLMNLLKDNPTQDFAALYSSSPLERQNSSSDSPRTDGMNSSCAGVNAKGKKKRPRGPEKSGVLPGAGAGGGLGIKSQQASMSQHHSVTHEDDFHRELLSMDVDASQNSIFDVNLTSDGLETPHSITPAPSQCGTPPPGSSMPYPLSHVQSQQQQPPGTIPPRMVRLPSSDSIGPDITEILQDLPDQTGKGSSGSHGQPPIGSGEEDGGPLGTPIRDSSSSGQGSAVFDSTDIFISNSNENPFTDAADLIEEAAVTAVTPNSDASSNNLFPDASDFNPDLLSQSIFNESSPSADEDIDLGKGFVGTSQQNTPSGTPQNPTSHGQSTPEASLKDPFDMSIVYGGNSGGGKPLLGQAPDLGDTHGGGSQSPLMMGLGATCADFKNTEPKVKQGLMRPKDENVGSGGSSSGLGMGSSSTESKQVKRSRTPSSEGKSKDKPPKRKKLDPDSKSPSHSSGGRPYTPPSGGLGSGGSISGGGSKSPGSSGCSQTPPGGATPPIPKITIQIQKGTITGGKTSSHSGYTSSSSATSSTGGASGASSGSSSKSHHSHSSSSGKIKSKEGSMSLGNNSKPGVGGGPSQLKGSSQGMGVGKPGSSPVTKHGLTGPGGTGGGMGSANKIKPQGGKPPGSLMNPNIKPNISPSHSRSSSSGDKLSSPMKMQQSQVPGTPPSSKAKSPIGSGGGNSGGSKSSSGGNIGSQKPVGGGTSSSSSSMSSVSMSFSGGSQSQYGNSGSGSGGTGGGSGSEGSGGPGQNNANNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGVGEDGCEVGPPVGGPGSASTPGVPGNVPGGPSSMGSSKHTSSSQSGEYKREKSDKEAKSKVMVSSGSGGDKKVMESKTGGVGGATLAKIIISKPDSGSPSIKAKVTLQKTGEASCESMRSQISSHKASPLFSGSTPKHDRSSPSYSRSPGYTSLNHDSESESGSSSVAEKSHQNSPSSDDDQTTRPIPPQDYMSSIPLSSGEKHKKHKKEKKKLKEKERERDREKEKKKSSMSMGSLSHSMKADSWSRSPISASDSSLSMLGSDRPSRSSPIYMRNEDDDLMDSALTGNL
Length1785
PositionMiddle
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.03
Grand average of hydropathy-0.593
Instability index55.36
Isoelectric point8.32
Molecular weight185224.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17361
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|    1086.52|     125|     125|    1254|    1378|       1
---------------------------------------------------------------------------
  614-  759 (100.92/19.77)	........PNFTGPITTLFG.ISR..ADRQ...AQGVecvtpG.........GvaGQ..Q...........QLQ.QQQQSQG......htddYSKV.....TQNPIL.......TSLLQI..TG....N......................VGS.....SPSSQNAP.QPH....QT..PPPTSspasntknhpmlmnLLKDNPTQDFAALYSsspleRQNSSS...D.....SPrTDGMNSSCAGVN..A
  760-  872 (105.67/21.06)	K...........GKKKRPRGPEKS..G..V...LPGA.....G.........A..G...................G...GLG..........IKSQ.....QASMSQ.......HHSVTH..ED....DfhrellsmdvdasqnsifdvnlTSD.....GLETPHSI.TPApsqcGT..PPPGS..............SM.P..YP...LSHV.....QS...................QQQQPPGTI..P
  883- 1030 (118.97/24.69)	SIG.PDI.TEILQDLPDQTGKGSS..GSHG...QPPI.....G....sgeedG..GPlgT...........PIRdSSSSGQGsavfdstdifISNS.....NENPFTdaadlieEAAVTA..V............................TPN.....SDASSNNL.FPD....AS..DFNPD..............LLSQSIFNESSPSAD.....EDIDLG...KG..FVGT.S..QQNTPSGTPqnP
 1031- 1149 (96.23/18.49)	TS..HGQ.STPEASLKDPFD.MSIvyGGNSgggKPLL.....GqapdlgdthG..GG..S...........Q....SPLMMG..........LGATcadfkNTEPKV.......KQGLMR..PKdenvG......................SGGsssglGMGSS................STES.................KQVK......RS.....RTPSSE...GK...S...........KDKP..P
 1159- 1249 (120.84/25.20)	KS..PSH.SSG...............GRPY...TPPS.....G.........G..LG..S...........G...GSISGGG..........SKSP.....GSSGCS.......QT...P..PG....G......................ATP.....PIPKIT.I.QIQ....KG..TITGG............................K.....TSSHSG...YT..SSSS.ATSSTGGASGAS..S
 1254- 1378 (232.95/55.78)	KSH.HSH.SSSSGKIKSKEGSMSL..GNNS...KPGV.....G.........G..GP..S...........QLK.GSSQGMG..........VGKP.....GSSPVT.......KHGLTG..PG....G......................TGG.....GMGSANKI.KPQ....GG..KPPGS..............LMNPNIKPNISPSHS.....RSSSSG...DK..LSSP.MKMQQSQVPGTP..P
 1383- 1488 (108.94/21.95)	KSPiGSG.GGNSGGSKSSSGG.NI..GSQ....KP.V.....G.........G..GT..SsssssmssvsmSFS.GGSQS.Q..........YGNS.....GS................G..SG....G......................TGG.....GSGSE.....GS....GG..PGQNN..............ANNPNAKGK.SPSRN.....KKPSLTaviDK..L...................
 1489- 1578 (89.69/16.70)	..................................KSV.....G.........G..GG..V...........GED.GCEVGPP..........VGGP.....GSA..S.......TPGVPGnvPG....G......................P.S.....SMGSSKHTsSSQ....SGeyKREKS................DKEAKSKVMVS........SGSGG...DK........KVMESKTGGVG..G
 1583- 1684 (112.30/22.87)	KII.ISKpDSGSPSIKAK...VTL..QKTG...EASC.....E.........S..MR..S...........QI...SSHKAS..........PLFS.....GSTP.........KH................................................DRS.SPS....YS..RSPG...............YTSLNHD...SESES.....GSSSVA...EKshQNSP.SSDDDQTTRPIP..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.23|      25|     122|     123|     149|       4
---------------------------------------------------------------------------
  123-  149 (42.91/31.77)	GSHLspSGTECYITS.DMFYVEV..QLDTS
  248-  275 (38.32/21.35)	GGHL..VSLHCYVSPyDIFEVETgsQLNVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.50|      33|      61|      26|      60|       5
---------------------------------------------------------------------------
   26-   60 (50.38/49.75)	GNQTLGDRVksEDVTEAEKQSRMAALLERLH..AKHN
   86-  120 (50.11/41.35)	GHQLLLNCL..ETLQRALKVSSLSSMTDRLEsiARQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.68|      11|     116|     303|     313|       6
---------------------------------------------------------------------------
  303-  313 (19.98/10.25)	APLITGSHPID
  320-  330 (19.70/ 9.99)	FSTVTNSNCVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.37|      12|      15|    1697|    1708|       8
---------------------------------------------------------------------------
 1697- 1708 (21.03/17.02)	EKHKKHKKEKKK
 1713- 1724 (20.34/16.20)	ERERDREKEKKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17361 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQTVETMVKNNPPPSGSPTYNMTIGDGTNPIGLTGITEGNTPTGVGPPGGPNFTGPITTLFGISRADRQAQGVECVTPGGVAGQQQLQQQQQSQGHTDDYSKVTQNPILTSLLQITGNVGSSPSSQNAPQPHQTPPPTSSPASNTKNHPMLMNLLKDNPTQDFAALYSSSPLERQNSSSDSPRTDGMNSSCAGVNAKGKKKRPRGPEKSGVLPGAGAGGGLGIKSQQASMSQHHSVTHEDDFHRELLSMDVDASQNSIFDVNLTSDGLETPHSITPAPSQCGTPPPGSSMPYPLSHVQSQQQQPPGTIPPRMVRLPSSDSIGPDITEILQDLPDQTGKGSSGSHGQPPIGSGEEDGGPLGTPIRDSSSSGQGSAVFDSTDIFISNSNENPFTDAADLIEEAAVTAVTPNSDASSNNLFPDASDFNPDLLSQSIFNESSPSADEDIDLGKGFVGTSQQNTPSGTPQNPTSHGQSTPEASLKDPFDMSIVYGGNSGGGKPLLGQAPDLGDTHGGGSQSPLMMGLGATCADFKNTEPKVKQGLMRPKDENVGSGGSSSGLGMGSSSTESKQVKRSRTPSSEGKSKDKPPKRKKLDPDSKSPSHSSGGRPYTPPSGGLGSGGSISGGGSKSPGSSGCSQTPPGGATPPIPKITIQIQKGTITGGKTSSHSGYTSSSSATSSTGGASGASSGSSSKSHHSHSSSSGKIKSKEGSMSLGNNSKPGVGGGPSQLKGSSQGMGVGKPGSSPVTKHGLTGPGGTGGGMGSANKIKPQGGKPPGSLMNPNIKPNISPSHSRSSSSGDKLSSPMKMQQSQVPGTPPSSKAKSPIGSGGGNSGGSKSSSGGNIGSQKPVGGGTSSSSSSMSSVSMSFSGGSQSQYGNSGSGSGGTGGGSGSEGSGGPGQNNANNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGVGEDGCEVGPPVGGPGSASTPGVPGNVPGGPSSMGSSKHTSSSQSGEYKREKSDKEAKSKVMVSSGSGGDKKVMESKTGGVGGATLAKIIISKPDSGSPSIKAKVTLQKTGEASCESMRSQISSHKASPLFSGSTPKHDRSSPSYSRSPGYTSLNHDSESESGSSSVAEKSHQNSPSSDDDQTTRPIPPQDYMSSIPLSSGEKHKKHKKEKKKLKEKERERDREKEKKKSSMSMGSLSHSMKADSWSRSPISASDSSLSMLGSDRPSRSSPIYMRNEDDDLMDSALTGNL
564
1785










Molecular Recognition Features






MoRF SequenceStartStop




1) DPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDHPGLA
2) YRLMHI
198
164
234
169