<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17356

Description mediator of RNA polymerase II transcription subunit 12 isoform X3
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQFPSQGCSSPLPAMPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGSGAGGHPAHGILTQQSTALPPTPTSQPAGGSQPQTPFTDFYICPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSGLPMPGGNTTFTQQVRSKLREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERIEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDAGISVKMEQDTGLSESMEIDPNSSANFEEMFSPPMHCESKGSPSPEKPAPDLDSKPNCKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCNHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDSEFMNEAIANPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDYRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSDKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHPACLDEISEGRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSSNPAGNGAAVQGGSASNTNSTTSKIKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKIAKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPVPKEPEKTMMEAVKAEKNKPAVPSESNKKKSKKKKSSSTNTEDHRVNYQTNMGPEMVNPYSRPPYNPQSMVMYTQNQPLPPGGPGLETPCRPGRIPPMNKISPRPNYPHSMGGMFDRQNQMPYKPQSQNPRQQLVARLQNPSLGQMKQMAHNQAYSAMQGYTPYVPIQQHPSQAGGLGSSSYVNQNFQTTHPVPNPAVVDPLRQMQQRPSGYIHQQAPGYAHNMQNTPRFAHQPLNPNPVIHGMSGVSHIASQGVYPGLRSNQMLADQQQQQQQQQQQQQQQQQQQQQQQQQQAQQQHFYLRHASLRAQVQQQQQVQQQVQQQVQQQQVQQQQQQVQQQQVPPQQQVPQQQQQQVSTVPPPGQTQNQGLNMQPLPPQQPMFPRQGMQQTQQQQQTAALVRQLQQQLSNTQPGQGTTPYY
Length2152
PositionKinase
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.530
Instability index57.42
Isoelectric point6.79
Molecular weight241697.44
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17356
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     105.38|      15|      15|    2000|    2014|       1
---------------------------------------------------------------------------
 2000- 2012 (25.14/ 7.90)	....DQQQQ.QQQQQQ.QQ
 2013- 2028 (29.52/10.58)	QQ.qQQQQQ.QQQQQQ.AQ
 2055- 2071 (25.63/ 8.20)	QQ..VQQQQvQQQQQQvQQ
 2111- 2127 (25.10/ 7.88)	QPmfPRQGM.QQTQQQ.QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     268.21|      35|      37|    1918|    1952|       2
---------------------------------------------------------------------------
 1780- 1805 (39.85/16.99)	.NYQTN....M...............GPEMVNP.......YSRPP..YNPQSMVM
 1808- 1845 (44.18/19.81)	QN........Q.PL.PpggpgletpcRPGRIPPMNKI...SPRPN..YPHSM..G
 1846- 1885 (42.75/18.88)	GMFDRQ....N.QM.P.........yKPQSQNPRQQLvarLQNPSlGQMKQMAHN
 1886- 1909 (38.99/16.43)	QAYSAM....Q.GY.T................PYVPI...QQHPS......QAGG
 1918- 1952 (67.17/34.76)	QNFQTT....H.PV.P..........NPAVVDPLRQM...QQRPS.GYIHQQAPG
 1955- 1991 (35.27/14.01)	HNMQNTprfaHqPLnP..........NP.VIHGMSGV...SHIAS.QGVY...PG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.14|      44|      86|     702|     745|       4
---------------------------------------------------------------------------
  645-  694 (29.11/12.90)	...PSDESERKEQDAGIsvkmeqdtglsesmeiDPnssaNFEEMFSPPMHC...........ES
  702-  745 (82.60/52.40)	KPAPDLDSKPNCKDKGM................DP....AFPQLYDQPRHIQYATHFPIPQEES
  785-  829 (63.43/38.24)	KSTAETGGEEGQKRKRS................KP...eAFPTAEDIFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.65|      32|      86|    1038|    1071|       5
---------------------------------------------------------------------------
 1038- 1071 (53.17/39.12)	C...NVLMDV..CVDYRDPE.RVNDigILC.AELT..A......YCRSL
 1073- 1111 (34.26/18.22)	AewlGILKAL..CCSSNNGNcGFND..LLCnVDVSdlS......FHDSL
 1123- 1159 (38.22/21.23)	C...LLLEDLvrCVAI..PS.LLN...AAC.SEQD..SepgarlTCRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.72|      16|      50|    2082|    2097|       6
---------------------------------------------------------------------------
 2082- 2097 (32.21/14.99)	QQQQQQVS.TVPPPGQT
 2133- 2149 (23.50/ 8.70)	RQLQQQLSnTQPGQGTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.81|      33|     348|    1230|    1283|      11
---------------------------------------------------------------------------
 1206- 1239 (52.41/44.93)	VFA..VLKAVF...MLGDAELR.....GSGLSHPAcLDEISEGR
 1250- 1292 (43.41/39.86)	VYAkyVLKTICqqeWVGERCLKslsedSSALQDPV.LVNIQAQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.63|      25|      41|    1381|    1405|      16
---------------------------------------------------------------------------
 1381- 1405 (41.37/25.95)	VQGGSASNTNSTTSKIKPILSSS..ER
 1422- 1448 (37.26/22.61)	VQGHVLKAAGEELEKGQHLGSSSrkER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.62|      12|     342|    1699|    1710|      18
---------------------------------------------------------------------------
 1699- 1710 (23.27/14.41)	QQRFLLYHTHLK
 2029- 2040 (23.35/14.48)	QQHFYLRHASLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.04|      16|     342|     243|     265|      19
---------------------------------------------------------------------------
  247-  262 (31.42/29.06)	MLDRHEFLTWVLECFE
 1458- 1473 (27.62/ 6.08)	LLSQQPFLSLVLTCLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.40|      10|      15|    1643|    1657|      21
---------------------------------------------------------------------------
 1643- 1653 (13.31/ 6.88)	TKgNKIAGFEK
 1660- 1669 (18.08/15.58)	TK.QKISPWDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.36|      14|      52|    1554|    1569|      22
---------------------------------------------------------------------------
 1535- 1548 (23.27/13.63)	QQTTEWAVLLLDII
 1556- 1569 (23.09/10.37)	QSNNELFTTVLDML
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17356 with Med12 domain of Kingdom Metazoa
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