<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17355

Description mediator of RNA polymerase II transcription subunit 12 isoform X2
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQFPSQGCSSPLPAMPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGSGAGGHPAHGILTQQSTALPPTPTSQPAGGSQPQTPFTDFYICPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSGLPMPGGNTTFTQQVRSKLREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERIEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDAGISVKMEDTGLSESMEIDPNSSANFEEMFSPPMHCESKGSPSPEKPAPDLDSKPNCKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCNHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDSEFMNEAIANPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDYRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSDKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHPACLDEISEGRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSSNPAGNGAAVQGGSASNTNSTTSKIKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKIAKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPVPKEPEKTMMEAVKAEKNKPAVPSESNKKKSKKKKSSSTNTEDHRVNYQTNMGPEMVNPYSRPPYNPQSMVMYTQNQPLPPGGPGLETPCRPGRIPPMNKISPRPNYPHSMGGMFDRQNQMPYKPQSQNPRQQLVARLQNPSLGQMKQMAHNQAYSAMQVTPGYTPYVPIQQHPSQAGGLGSSSYVNQNFQTTHPVPNPAVVDPLRQMQQRPSGYIHQQAPGYAHNMQNTPRFAHQPLNPNPVIHGMSGVSHIASQGVYPGLRSNQMLADQQQQQQQQQQQQQQQQQQQQQQQQQQAQQQHFYLRHASLRAQVQQQQQVQQQVQQQVQQQQVQQQQQQVQQQQVPPQQQVPQQQQQQVSTVPPPGQTQNQGLNMQPLPPQQPMFPRQGMQQTQQQQQTAALVRQLQQQLSNTQPGQGTTPYY
Length2154
PositionKinase
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.527
Instability index57.21
Isoelectric point6.79
Molecular weight241866.66
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17355
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     106.23|      15|      15|    2002|    2016|       1
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 2012- 2027 (31.49/10.41)	Q.QQQQ.qQQ........QQQ.QQQQQ
 2054- 2069 (28.01/ 8.56)	Q.VQQQ..VQ........QQQvQQQQQ
 2070- 2087 (23.22/ 6.02)	QvQQQQvpPQ........QQV.PQQQQ
 2107- 2129 (23.50/ 6.17)	Q.PLPP..QQpmfprqgmQQT.QQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     282.18|      39|      41|    1898|    1937|       2
---------------------------------------------------------------------------
 1752- 1792 (41.21/20.72)	PAVP......SESNKKKSKKKKSSS....tntedhrvNYQTN....M......GPEMVNPY
 1796- 1830 (47.89/25.58)	PYNPqsmvmyTQNQPLPPGGPG................LET.......PC...RPGRIPPM
 1832- 1863 (45.36/23.74)	KISP......RPNYPHSMGGM.................FDRQ....N.QM.PyKPQSQNPR
 1865- 1890 (37.93/18.34)	QLVA......RLQNPS....LG......Q........MKQMA....H......NQA.YSAM
 1898- 1937 (71.06/47.02)	PYVP......IQQHPSQAGGLGSSSYVnQ........NFQTT....H.PV.P.NPAVVDPL
 1946- 1979 (38.73/18.92)	GYIH.......QQAP....G.....YA.H........NMQNTprfaHqPLnP.NP.VIHGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.75|      18|      39|    1994|    2011|       3
---------------------------------------------------------------------------
 1994- 2011 (33.48/15.12)	LRSNQMLADQQQQQQQQQ
 2036- 2053 (32.27/14.32)	LRHASLRAQVQQQQQVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.54|      44|      84|     701|     744|       4
---------------------------------------------------------------------------
  645-  693 (29.51/12.53)	...PSDESERKEQDAGIsvkmedtglsesmeiDPnssaNFEEMFSPPMHC...........ES
  701-  744 (82.60/49.95)	KPAPDLDSKPNCKDKGM...............DP....AFPQLYDQPRHIQYATHFPIPQEES
  784-  828 (63.43/36.44)	KSTAETGGEEGQKRKRS...............KP...eAFPTAEDIFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.65|      32|      85|    1037|    1070|       6
---------------------------------------------------------------------------
 1037- 1070 (53.17/36.94)	C...NVLMDV..CVDYRDPE.RVNDigILC.AELT..A......YCRSL
 1072- 1110 (34.26/17.17)	AewlGILKAL..CCSSNNGNcGFND..LLCnVDVSdlS......FHDSL
 1122- 1158 (38.22/20.02)	C...LLLEDLvrCVAI..PS.LLN...AAC.SEQD..SepgarlTCRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.83|      19|      42|    1478|    1496|       9
---------------------------------------------------------------------------
 1478- 1496 (33.75/22.48)	REGLLTSLYSQVQ...QIVTNW
 1518- 1539 (30.08/19.14)	RLNLVGGMFDTVQrstQQTTEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.38|      13|      55|    1383|    1396|      16
---------------------------------------------------------------------------
   57-   69 (25.01/ 9.74)	GSARNVNFNPSKI
 1383- 1395 (23.36/13.24)	GSASNTNSTTSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.52|      30|      40|    1230|    1259|      17
---------------------------------------------------------------------------
 1230- 1259 (50.42/34.40)	CLDEISEGRNVSIETASLDVYAKYVLKTIC
 1268- 1297 (48.10/32.44)	CLKSLSEDSSALQDPVLVNIQAQRLLQLIC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17355 with Med12 domain of Kingdom Metazoa
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