<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17354

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQFPSQGCSSPLPAMPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGSGAGGHPAHGILTQQSTALPPTPTSQPAGGSQPQTPFTDFYICPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSGLPMPGGNTTFTQQVRSKLREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERIEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDAGISVKMEQDTGLSESMEIDPNSSANFEEMFSPPMHCESKGSPSPEKPAPDLDSKPNCKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCNHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDSEFMNEAIANPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDYRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSDKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHPACLDEISEGRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSSNPAGNGAAVQGGSASNTNSTTSKIKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKIAKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPVPKEPEKTMMEAVKAEKNKPAVPSESNKKKSKKKKSSSTNTEDHRVNYQTNMGPEMVNPYSRPPYNPQSMVMYTQNQPLPPGGPGLETPCRPGRIPPMNKISPRPNYPHSMGGMFDRQNQMPYKPQSQNPRQQLVARLQNPSLGQMKQMAHNQAYSAMQVTPGYTPYVPIQQHPSQAGGLGSSSYVNQNFQTTHPVPNPAVVDPLRQMQQRPSGYIHQQAPGYAHNMQNTPRFAHQPLNPNPVIHGMSGVSHIASQGVYPGLRSNQMLADQQQQQQQQQQQQQQQQQQQQQQQQQQAQQQHFYLRHASLRAQVQQQQQVQQQVQQQVQQQQVQQQQQQVQQQQVPPQQQVPQQQQQQVSTVPPPGQTQNQGLNMQPLPPQQPMFPRQGMQQTQQQQQTAALVRQLQQQLSNTQPGQGTTPYY
Length2155
PositionKinase
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.528
Instability index57.28
Isoelectric point6.79
Molecular weight241994.79
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17354
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     106.23|      15|      15|    2003|    2017|       1
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 2013- 2028 (31.49/12.20)	Q.QQQQ.qQQ........QQQ.QQQQQ
 2055- 2070 (28.01/10.05)	Q.VQQQ..VQ........QQQvQQQQQ
 2071- 2088 (23.22/ 7.09)	QvQQQQvpPQ........QQV.PQQQQ
 2108- 2130 (23.50/ 7.26)	Q.PLPP..QQpmfprqgmQQT.QQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     282.18|      39|      41|    1899|    1938|       2
---------------------------------------------------------------------------
 1753- 1793 (41.21/17.89)	PAVP......SESNKKKSKKKKSSS....tntedhrvNYQTN....M......GPEMVNPY
 1797- 1831 (47.89/22.11)	PYNPqsmvmyTQNQPLPPGGPG................LET.......PC...RPGRIPPM
 1833- 1864 (45.36/20.51)	KISP......RPNYPHSMGGM.................FDRQ....N.QM.PyKPQSQNPR
 1866- 1891 (37.93/15.83)	QLVA......RLQNPS....LG......Q........MKQMA....H......NQA.YSAM
 1899- 1938 (71.06/40.70)	PYVP......IQQHPSQAGGLGSSSYVnQ........NFQTT....H.PV.P.NPAVVDPL
 1947- 1980 (38.73/16.33)	GYIH.......QQAP....G.....YA.H........NMQNTprfaHqPLnP.NP.VIHGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.75|      18|      39|    1995|    2012|       3
---------------------------------------------------------------------------
 1995- 2012 (33.48/15.18)	LRSNQMLADQQQQQQQQQ
 2037- 2054 (32.27/14.38)	LRHASLRAQVQQQQQVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.28|      35|      37|    1252|    1288|       5
---------------------------------------------------------------------------
 1209- 1236 (30.37/15.38)	..VLKAVF...MLGDAELR.....GSGLS..HPAcLDEI.S
 1253- 1290 (51.52/38.41)	KYVLKTICQqeWVGERCLKSLSEDSSALQ..DPV.LVNIqA
 1291- 1324 (43.39/25.58)	QRLLQLICY....PHRQLDSDDGDNPQRQriKRI.LQNM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.14|      44|      85|     702|     745|       6
---------------------------------------------------------------------------
  645-  694 (29.11/11.05)	...PSDESERKEQDAGIsvkmeqdtglsesmeiDPnssaNFEEMFSPPMHC...........ES
  702-  745 (82.60/44.95)	KPAPDLDSKPNCKDKGM................DP....AFPQLYDQPRHIQYATHFPIPQEES
  785-  829 (63.43/32.80)	KSTAETGGEEGQKRKRS................KP...eAFPTAEDIFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.65|      32|      85|    1038|    1071|       7
---------------------------------------------------------------------------
 1038- 1071 (53.17/49.42)	C...NVLMDV..CVDYRDPE.RVNDigILC.AELT..A......YCRSL
 1073- 1111 (34.26/23.05)	AewlGILKAL..CCSSNNGNcGFND..LLCnVDVSdlS......FHDSL
 1123- 1159 (38.22/26.84)	C...LLLEDLvrCVAI..PS.LLN...AAC.SEQD..SepgarlTCRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.83|      19|      41|    1479|    1497|      10
---------------------------------------------------------------------------
 1479- 1497 (33.75/19.39)	REGLLTSLYSQVQ...QIVTNW
 1519- 1540 (30.08/16.50)	RLNLVGGMFDTVQrstQQTTEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.59|      36|     327|     243|     301|      15
---------------------------------------------------------------------------
  243-  283 (54.22/40.25)	FQDGMLdrhEFLTWVLECFEKvrPGEDELLRLLLPLLLQYS
  571-  606 (60.38/30.19)	FQDVLL...QFLDTQAPTLTE..PGNESERIEFSNLVLLFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.38|      13|      54|    1384|    1397|      18
---------------------------------------------------------------------------
   57-   69 (25.01/12.86)	GSARNVNFNPSKI
 1384- 1396 (23.36/17.38)	GSASNTNSTTSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.88|      14|      51|     841|     856|      20
---------------------------------------------------------------------------
  841-  854 (25.46/21.17)	SFALGMSYHLPLVQ
  874-  887 (22.42/ 9.22)	DFAIQLLNELSLVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17354 with Med12 domain of Kingdom Metazoa
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