<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17353

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTATANWVANGASLEDCHSNIFSLAELNGIKWRCYSFSGGGEYGPVISAPAQDDPVLRSFMRCVQANLLCVWRRKIKPDAKQLWIFWWGEEPNLSDVIHHELEVAEEGFWECGLSYECRTLLFKAIHNLLERCLMDKGFVRIGKWFFKPQDLEGKTLGNSEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEQHIRLAQTSATPVQVVLSPYGLSGTLTGQAYKMSDPAARKLMEDWSYFYPMVLPQKEGSGEKDQKEAGHAFDRGAHVAVDVIVGGVSMTYPAAFVLIAQADLPVEQPPLAPAVQGPNKELNNCSVPLTPPTSPEQPCSADSGFVTSASNAPTPDSSMGITSISPKHSGKKLTSQVVHQAWKECYLNQSQHTPNQQTDGTPTKEVPNGVNMWNFNDLGTRASCSCSRLKQQKVSMSATSTANPQTCASSALSSGSSLYPTSSLPKHKTSDKAEKADKQSKRPAVFPFHHRLSATQETPLEQDPPGGAQLGSLVALEPPVEPLASLPSCKYSKPLANSRKPPESLLHSPMSPLPPTLSPHPRIQDPEVLEVPVDMPVCPDGASGLGMITSETAVYTTLLRQRENGLGWWRGFRTPRTNKTDFRTPELPTDKLEDMKTETTTDGALFKRLYTQTHKRFKISEERMKEHIHTLGLFEQPEAEPLRENGDDPYDFKEGDIEYPFPSSKRLKSSGREPSKKAKGEEITSNGSLPDGKDAMSIFNSAPKSDDSSQDDAAAKTNPSLTREKDLVVNISDLDNIFDEDEEELGTVYPNQQSTKLLVSTEDRPIGKEGRVSVPYPTIADLQIMFPTPPSLEPHPVFSPITPYRDTPSQEPPAPSGVFDHLPSLASTHLSDSRMEMEEGAVSPRQDDIKPQMGSSMFAPLSCLPSQNLPPLKIPDQCHYRPSWALLPKMEHFMTIMHPQNPAFNKDGYTNNTLTDQDYGQMSATTASVSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARPGPSLPEAHSLYLVLLLSDSVLSVFKDRNFDSCCICACNMNVKGADVGVYIPDFTCEDQYRCMCGFSAIVNRRLAHGTGLFLEDELDIFGRTSEVGQAAERRLALCRREPTVGDSRAKQLQGVSSASSSVMTVLQEQCSQPISSLASLHLPQNSSCRGRKGALLQSWMSEKQWADGSDACVDCYNALEQSLQYVDNPTGGKVDLAVVRSSAFHSWPHTNVVEMSRLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWDNIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYVVVCPNSTSLLAAARAFFQELSAVYETCRLGKHRPLSKVSKDGFVRVGEEVEPEKLEELDMDQWMTGPWAGQQHTDNISKLKLYAYAFKQQLGPQLSTLTMDSSLLLPPKAQLPLNNTSSSGQPQSQTWTADGEQASGTANASTPSGATSGQTGEANQGGSTESKGPQSSTPPANTPAENTELSSEQSRIGIPTVADSADGLANPPAIVIYIVDAFITSCGQRNETGEEDEGEEVESGSIWLLGLLRCYTEMLQNLPEAMRPALVLQVVPCQYLLQPASGENHLYLQHLRSLAFSCYSQSRRLLPQQTHIKSLTGFGPVSTVTSVLKGPEFPTPLQLYSPPFILGLTRAKQPEPGEIWAEPPPKYNVLFVGYCLSHDQRWILVSCTDQQGELLETCIINIDVPNRSRRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWTSLLGEHSLQSIGRQLREACRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSATTQLAPSSYPTEDNNDDMFDLPFPDELENDIGHDMMLITNLHPSPNPSPVPSPGSPSGMGMGSHFHHTRSQGERLLSRDNPPEELKQQPLALGYYVSTAQTTGLPHWFWASCPQAENQCPLFLKASLHHHISIAQSEEITSDKNKRTPHPLDSKTTSDVLRFVLEQYNALSWLTCTPATQDRQSCLPVHLAVLIQMYNAILNML
Length2107
PositionMiddle
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.417
Instability index57.14
Isoelectric point5.56
Molecular weight231294.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17353
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.84|      41|      61|     452|     496|       1
---------------------------------------------------------------------------
  452-  496 (69.82/42.47)	PTSSLPKHKTSdkaeKADKQSKRPAVFPFHHRLSATQET....PLEQDP
  514-  558 (73.02/36.87)	PLASLPSCKYS....KPLANSRKPPESLLHSPMSPLPPTlsphPRIQDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     685.14|     226|     681|     979|    1439|       2
---------------------------------------------------------------------------
 1145- 1439 (330.46/457.70)	AKQLQGVSSASS.SVMTVlqeqC...SQPISSLASlhLPQN...SSCRGRKGAL.LQ.SWMSEKQWADGSDACVDCYNALEQsLQYVDNPTGGKVDlavvrsSAFhSWPHTNvvEMSRLSSQDMVrMLLSLQPflqdaiqkkrtgrtwdniqhVQGPLTWQ............QFHKMAGRGS..YGSEESPEPLPIPTVLLGYdrerdFLALS.PLALPFWeklllepyggqrdvaYVVVCP...NSTSLLAAArAFFQELS.AVYETCRLGKHR....PL.SKVSKDGFVRVgeevepekLEELDMDQWMTGPWAGQqhtDNISKL
 1831- 2089 (354.68/147.31)	ACRMCGISAADSpSILSA....ClvaMEPQGSFVV..MPDAvtmGSVFGRSTALnLQtSQLNTPQDASCTHILVFPTSATTQ.LAPSSYPTEDNND......DMF.DLPFPD..ELENDIGHDMM.LITNLHP....................SPNPSPVPspgspsgmgmgsHFHHTRSQGErlLSRDNPPEELKQQPLALGY.....YVSTAqTTGLPHW...............FWASCPqaeNQCPLFLKA.SLHHHISiAQSEEITSDKNKrtphPLdSKTTSDVLRFV........LEQYNALSWLTCTPATQ...DRQSCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     423.47|     137|     681|     199|     349|       3
---------------------------------------------------------------------------
  199-  347 (207.32/106.19)	LAQTSATPVQvVLSPYGLSGTLtgqAYKmsdPaARKLMEDWSYFYPMVLPQKEgSGEKDQKEAGHAFDR..GAHVAVDVIVGGVSMTYPAAfvLIAQADLPVEQPPLAP.......AVQGPNK.ELNNCSVPLTPPtSPEQPCSADSGFVTSASNAPTP
  890- 1036 (216.15/83.69)	FAPLSCLPSQ.NLPPLKIPDQC...HYR...P.SWALLPKMEHFMTIMHPQNP.AFNKDGYTNNTLTDQdyGQMSATTASVSTTTGILPSP..ATPRFSVPTPRTPRTPrgintasSGQGSVKqDGTELSSPVSTP.STSLPLSSVEPLARPGPSLPEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.81|      34|      61|    1466|    1503|       4
---------------------------------------------------------------------------
 1466- 1503 (50.08/34.78)	PPkAQLPLNNTSSSGQpQSQTWTAD.GEQASGTANasTP
 1530- 1564 (57.73/26.87)	PP.ANTPAENTELSSE.QSRIGIPTvADSADGLAN..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.65|      52|      55|     648|     700|       5
---------------------------------------------------------------------------
  648-  700 (86.75/44.28)	RfKISEERMKEHIHTLG.LFEQPEAEPLRENGDDPYDFKEGDIEYPF.PSSKRLK
  704-  757 (76.91/35.27)	R.EPSKKAKGEEITSNGsLPDGKDAMSIFNSAPKSDDSSQDDAAAKTnPSLTREK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.17|      34|     870|     781|     851|       8
---------------------------------------------------------------------------
  818-  851 (67.94/66.56)	FPTPPSLEPHPVFSPITPYRD.TPSQ...EPPAPSGVF
 1689- 1726 (55.24/12.37)	FPTPLQLYSPPFILGLTRAKQpEPGEiwaEPPPKYNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.89|      19|      70|    1504|    1522|      11
---------------------------------------------------------------------------
 1504- 1522 (32.85/17.30)	SGATSGQTGEANQGGSTES
 1577- 1595 (34.05/18.19)	SCGQRNETGEEDEGEEVES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.32|      34|    1223|     377|     444|      12
---------------------------------------------------------------------------
  384-  423 (53.49/74.97)	HTP.NQQTD.GTPtkEVPNGvnmwNFNDLGTRASCSCSRLKQ
  605-  640 (50.84/12.67)	RTPrTNKTDfRTP..ELPTD....KLEDMKTETTTDGALFKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.70|      56|    1483|     110|     170|      16
---------------------------------------------------------------------------
  110-  170 (90.50/89.09)	WECGLsYECRTLLFKAIHNLLERCLMDKgfVRIGKWFFKPQDleGKTLGNSEHL.SCSFSFF
 1599- 1655 (97.20/74.59)	WLLGL.LRCYTEMLQNLPEAMRPALVLQ..VVPCQYLLQPAS..GENHLYLQHLrSLAFSCY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17353 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEDEEELGTVYPNQQSTKLLVSTEDRPIGKEGRVSV
2) DMMLITNLHPSPNPSPVPSPGSPSGMGMGSHFHHTRSQGERLLSRDNPPEE
3) ECYLNQSQHTPNQQTDGTPTKEVPNGVNMWN
4) EHIHTLGLFEQPEAEPLRENGDDPYDFKEGDIEY
5) EQPPLAPAVQGPNKELNNCSVPLTPPTSPEQPCSADSGFVTSASNAPTPDSSMGITSISPKHSG
6) FPSSKRLKSSGREPSKKAKGEEITSNGSLPDGKDAMSIFNSAPKSDDSSQDDAAAKTNPSLTREKDLVVNISDLDNI
7) KVSMSATSTANPQTCASSALSSGSSLYPTSSLPKHKTSDKAEKADKQSKRPAVFPFHHRLSATQETPLEQDPPGGAQLGSLVALE
8) LPSCKYSKPLANSRKPPESLLHSPMSPLPPTLSPHPRIQDPEVLEVPVDMP
9) QIMFPTPPSLEPHPVFSPITPYRDTPSQEPPAPSGVFDHLPSLASTHLSDSRMEMEEGAVSPRQDDIKPQMGSSMFAPLS
10) TIMHPQNPAFNKDGYTNNTLTDQDYGQMSATTASVSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARP
11) TLTMDSSLLLPPKAQLPLNNTSSSGQPQSQTWTADGEQASGTANASTPSGATSGQTGEANQGGSTESKGPQSSTPPANTPAENTELSSEQSRIGIPTVADS
12) TNKTDFRTPELPTDKLEDMKTETTTDGALFK
771
1937
376
658
299
693
425
518
815
927
1456
609
806
1987
406
691
362
769
509
568
894
1029
1556
639










Molecular Recognition Features






MoRF SequenceStartStop




1) PYDFKEG
681
687