<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17353

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTATANWVANGASLEDCHSNIFSLAELNGIKWRCYSFSGGGEYGPVISAPAQDDPVLRSFMRCVQANLLCVWRRKIKPDAKQLWIFWWGEEPNLSDVIHHELEVAEEGFWECGLSYECRTLLFKAIHNLLERCLMDKGFVRIGKWFFKPQDLEGKTLGNSEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEQHIRLAQTSATPVQVVLSPYGLSGTLTGQAYKMSDPAARKLMEDWSYFYPMVLPQKEGSGEKDQKEAGHAFDRGAHVAVDVIVGGVSMTYPAAFVLIAQADLPVEQPPLAPAVQGPNKELNNCSVPLTPPTSPEQPCSADSGFVTSASNAPTPDSSMGITSISPKHSGKKLTSQVVHQAWKECYLNQSQHTPNQQTDGTPTKEVPNGVNMWNFNDLGTRASCSCSRLKQQKVSMSATSTANPQTCASSALSSGSSLYPTSSLPKHKTSDKAEKADKQSKRPAVFPFHHRLSATQETPLEQDPPGGAQLGSLVALEPPVEPLASLPSCKYSKPLANSRKPPESLLHSPMSPLPPTLSPHPRIQDPEVLEVPVDMPVCPDGASGLGMITSETAVYTTLLRQRENGLGWWRGFRTPRTNKTDFRTPELPTDKLEDMKTETTTDGALFKRLYTQTHKRFKISEERMKEHIHTLGLFEQPEAEPLRENGDDPYDFKEGDIEYPFPSSKRLKSSGREPSKKAKGEEITSNGSLPDGKDAMSIFNSAPKSDDSSQDDAAAKTNPSLTREKDLVVNISDLDNIFDEDEEELGTVYPNQQSTKLLVSTEDRPIGKEGRVSVPYPTIADLQIMFPTPPSLEPHPVFSPITPYRDTPSQEPPAPSGVFDHLPSLASTHLSDSRMEMEEGAVSPRQDDIKPQMGSSMFAPLSCLPSQNLPPLKIPDQCHYRPSWALLPKMEHFMTIMHPQNPAFNKDGYTNNTLTDQDYGQMSATTASVSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARPGPSLPEAHSLYLVLLLSDSVLSVFKDRNFDSCCICACNMNVKGADVGVYIPDFTCEDQYRCMCGFSAIVNRRLAHGTGLFLEDELDIFGRTSEVGQAAERRLALCRREPTVGDSRAKQLQGVSSASSSVMTVLQEQCSQPISSLASLHLPQNSSCRGRKGALLQSWMSEKQWADGSDACVDCYNALEQSLQYVDNPTGGKVDLAVVRSSAFHSWPHTNVVEMSRLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWDNIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYVVVCPNSTSLLAAARAFFQELSAVYETCRLGKHRPLSKVSKDGFVRVGEEVEPEKLEELDMDQWMTGPWAGQQHTDNISKLKLYAYAFKQQLGPQLSTLTMDSSLLLPPKAQLPLNNTSSSGQPQSQTWTADGEQASGTANASTPSGATSGQTGEANQGGSTESKGPQSSTPPANTPAENTELSSEQSRIGIPTVADSADGLANPPAIVIYIVDAFITSCGQRNETGEEDEGEEVESGSIWLLGLLRCYTEMLQNLPEAMRPALVLQVVPCQYLLQPASGENHLYLQHLRSLAFSCYSQSRRLLPQQTHIKSLTGFGPVSTVTSVLKGPEFPTPLQLYSPPFILGLTRAKQPEPGEIWAEPPPKYNVLFVGYCLSHDQRWILVSCTDQQGELLETCIINIDVPNRSRRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWTSLLGEHSLQSIGRQLREACRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSATTQLAPSSYPTEDNNDDMFDLPFPDELENDIGHDMMLITNLHPSPNPSPVPSPGSPSGMGMGSHFHHTRSQGERLLSRDNPPEELKQQPLALGYYVSTAQTTGLPHWFWASCPQAENQCPLFLKASLHHHISIAQSEEITSDKNKRTPHPLDSKTTSDVLRFVLEQYNALSWLTCTPATQDRQSCLPVHLAVLIQMYNAILNML
Length2107
PositionMiddle
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.417
Instability index57.14
Isoelectric point5.56
Molecular weight231294.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17353
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.84|      41|      61|     452|     496|       1
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  452-  496 (69.82/42.47)	PTSSLPKHKTSdkaeKADKQSKRPAVFPFHHRLSATQET....PLEQDP
  514-  558 (73.02/36.87)	PLASLPSCKYS....KPLANSRKPPESLLHSPMSPLPPTlsphPRIQDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     685.14|     226|     681|     979|    1439|       2
---------------------------------------------------------------------------
 1145- 1439 (330.46/457.70)	AKQLQGVSSASS.SVMTVlqeqC...SQPISSLASlhLPQN...SSCRGRKGAL.LQ.SWMSEKQWADGSDACVDCYNALEQsLQYVDNPTGGKVDlavvrsSAFhSWPHTNvvEMSRLSSQDMVrMLLSLQPflqdaiqkkrtgrtwdniqhVQGPLTWQ............QFHKMAGRGS..YGSEESPEPLPIPTVLLGYdrerdFLALS.PLALPFWeklllepyggqrdvaYVVVCP...NSTSLLAAArAFFQELS.AVYETCRLGKHR....PL.SKVSKDGFVRVgeevepekLEELDMDQWMTGPWAGQqhtDNISKL
 1831- 2089 (354.68/147.31)	ACRMCGISAADSpSILSA....ClvaMEPQGSFVV..MPDAvtmGSVFGRSTALnLQtSQLNTPQDASCTHILVFPTSATTQ.LAPSSYPTEDNND......DMF.DLPFPD..ELENDIGHDMM.LITNLHP....................SPNPSPVPspgspsgmgmgsHFHHTRSQGErlLSRDNPPEELKQQPLALGY.....YVSTAqTTGLPHW...............FWASCPqaeNQCPLFLKA.SLHHHISiAQSEEITSDKNKrtphPLdSKTTSDVLRFV........LEQYNALSWLTCTPATQ...DRQSCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     423.47|     137|     681|     199|     349|       3
---------------------------------------------------------------------------
  199-  347 (207.32/106.19)	LAQTSATPVQvVLSPYGLSGTLtgqAYKmsdPaARKLMEDWSYFYPMVLPQKEgSGEKDQKEAGHAFDR..GAHVAVDVIVGGVSMTYPAAfvLIAQADLPVEQPPLAP.......AVQGPNK.ELNNCSVPLTPPtSPEQPCSADSGFVTSASNAPTP
  890- 1036 (216.15/83.69)	FAPLSCLPSQ.NLPPLKIPDQC...HYR...P.SWALLPKMEHFMTIMHPQNP.AFNKDGYTNNTLTDQdyGQMSATTASVSTTTGILPSP..ATPRFSVPTPRTPRTPrgintasSGQGSVKqDGTELSSPVSTP.STSLPLSSVEPLARPGPSLPEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.81|      34|      61|    1466|    1503|       4
---------------------------------------------------------------------------
 1466- 1503 (50.08/34.78)	PPkAQLPLNNTSSSGQpQSQTWTAD.GEQASGTANasTP
 1530- 1564 (57.73/26.87)	PP.ANTPAENTELSSE.QSRIGIPTvADSADGLAN..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.65|      52|      55|     648|     700|       5
---------------------------------------------------------------------------
  648-  700 (86.75/44.28)	RfKISEERMKEHIHTLG.LFEQPEAEPLRENGDDPYDFKEGDIEYPF.PSSKRLK
  704-  757 (76.91/35.27)	R.EPSKKAKGEEITSNGsLPDGKDAMSIFNSAPKSDDSSQDDAAAKTnPSLTREK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.17|      34|     870|     781|     851|       8
---------------------------------------------------------------------------
  818-  851 (67.94/66.56)	FPTPPSLEPHPVFSPITPYRD.TPSQ...EPPAPSGVF
 1689- 1726 (55.24/12.37)	FPTPLQLYSPPFILGLTRAKQpEPGEiwaEPPPKYNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.89|      19|      70|    1504|    1522|      11
---------------------------------------------------------------------------
 1504- 1522 (32.85/17.30)	SGATSGQTGEANQGGSTES
 1577- 1595 (34.05/18.19)	SCGQRNETGEEDEGEEVES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.32|      34|    1223|     377|     444|      12
---------------------------------------------------------------------------
  384-  423 (53.49/74.97)	HTP.NQQTD.GTPtkEVPNGvnmwNFNDLGTRASCSCSRLKQ
  605-  640 (50.84/12.67)	RTPrTNKTDfRTP..ELPTD....KLEDMKTETTTDGALFKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.70|      56|    1483|     110|     170|      16
---------------------------------------------------------------------------
  110-  170 (90.50/89.09)	WECGLsYECRTLLFKAIHNLLERCLMDKgfVRIGKWFFKPQDleGKTLGNSEHL.SCSFSFF
 1599- 1655 (97.20/74.59)	WLLGL.LRCYTEMLQNLPEAMRPALVLQ..VVPCQYLLQPAS..GENHLYLQHLrSLAFSCY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17353 with Med13 domain of Kingdom Metazoa
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