<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17352

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTATANWVANGASLEDCHSNIFSLAELNGIKWRCYSFSGGGEYGPVISAPAQDDPVLRSFMRCVQANLLCVWRRKIKPDAKQLWIFWWGEEPNLSDVIHHELEVAEEGFWECGLSYECRTLLFKAIHNLLERCLMDKGFVRIGKWFFKPQDLEGKTLGNSEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEQHIRLAQTSATPVQVVLSPYGLSGTLTGQAYKMSDPAARKLMEDWSYFYPMVLPQKEGSGEKDQKEAGHAFDRGAHVAVDVIVGGVSMTYPAAFVLIAQADLPVEQPPLAPAVQGPNKELNNCSVPLTPPTSPEQPCSADSGFVTSASNAPTPDSSMGITSISPKHSGKKLTSQVVHQAWKECYLNQSQHTPNQQTDGTPTKEVPNGVNMWNFNDLGTRASCSCSRLKQQKVSMSATSTANPQTCASSALSSGSSLYPTSSLPKHKTSDKAEKADKQSKRPAVFPFHHRLSATQETPLEQDPPGGAQLGSLVALEPPVEPLASLPSCKYSKPLANSRKPPESLLHSPMSPLPPTLSPHPRIQDPEVLEVPVDMPVCPDGASGLGMITSETAVYTTLLRQRENGLGWWRGFRTPRTNKTDFRTPELPTDKLEDMKTETTTDGALFKRLYTQTHKRFKISEERMKEHIHTLGLFEQPEAEPLRENGDDPYDFKEGDIEYPFPSSKRLKSSGREPSKKAKGEEITSNGSLPDGKDAMSIFNSAPKSDDSSQDDAAAKTNPSLTREKDLVVNISDLDNIFDEDEEELGTVYPNQQSTKLLVSTEDRPIGKEGRVSVPYPTTVADLQIMFPTPPSLEPHPVFSPITPYRDTPSQEPPAPSGVFDHLPSLASTHLSDSRMEMEEGAVSPRQDDIKPQMGSSMFAPLSCLPSQNLPPLKIPDQCHYRPSWALLPKMEHFMTIMHPQNPAFNKDGYTNNTLTDQDYGQMSATTASVSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARPGPSLPEAHSLYLVLLLSDSVLSVFKDRNFDSCCICACNMNVKGADVGVYIPDFTCEDQYRCMCGFSAIVNRRLAHGTGLFLEDELDIFGRTSEVGQAAERRLALCRREPTVGDSRAKQLQGVSSASSSVMTVLQEQCSQPISSLASLHLPQNSSCRGRKGALLQSWMSEKQWADGSDACVDCYNALEQSLQYVDNPTGGKVDLAVVRSSAFHSWPHTNVVEMSRLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWDNIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYVVVCPNSTSLLAAARAFFQELSAVYETCRLGKHRPLSKVSKDGFVRVGEEVEPEKLEELDMDQWMTGPWAGQQHTDNISKLKLYAYAFKQQLGPQLSTLTMDSSLLLPPKAQLPLNNTSSSGQPQSQTWTADGEQASGTANASTPSGATSGQTGEANQGGSTESKGPQSSTPPANTPAENTELSSEQSRIGIPTVADSADGLANPPAIVIYIVDAFITSCGQRNETGEEDEGEEVESGSIWLLGLLRCYTEMLQNLPEAMRPALVLQVVPCQYLLQPASGENHLYLQHLRSLAFSCYSQSRRLLPQQTHIKSLTGFGPVSTVTSVLKGPEFPTPLQLYSPPFILGLTRAKQPEPGEIWAEPPPKYNVLFVGYCLSHDQRWILVSCTDQQGELLETCIINIDVPNRSRRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWTSLLGEHSLQSIGRQLREACRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSATTQLAPSSYPTEDNNDDMFDLPFPDELENDIGHDMMLITNLHPSPNPSPVPSPGSPSGMGMGSHFHHTRSQGERLLSRDNPPEELKQQPLALGYYVSTAQTTGLPHWFWASCPQAENQCPLFLKASLHHHISIAQSEEITSDKNKRTPHPLDSKTTSDVLRFVLEQYNALSWLTCTPATQDRQSCLPVHLAVLIQMYNAILNML
Length2108
PositionMiddle
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.418
Instability index57.12
Isoelectric point5.56
Molecular weight231381.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17352
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.41|      34|      55|     820|     854|       1
---------------------------------------------------------------------------
  302-  337 (39.35/ 9.84)	PLAPAVQgPNkelnNCSVPLTP.PTSPEQPCSADSG......F.
  820-  853 (69.76/25.08)	PTPPSLE.PH....PVFSPITPYRDTPSQEPPAPSGV.....FD
  877-  909 (55.45/15.23)	PRQDDIK.PQ....MGSSMFAPLSCLPSQNLP.PLKI.....PD
 1945- 1970 (31.86/ 8.10)	.....LH.PS....PNPSPV......PS..PGSPSGMgmgshFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.84|      41|      61|     452|     496|       2
---------------------------------------------------------------------------
  452-  496 (69.82/41.71)	PTSSLPKHKTSdkaeKADKQSKRPAVFPFHHRLSATQET....PLEQDP
  514-  558 (73.02/36.20)	PLASLPSCKYS....KPLANSRKPPESLLHSPMSPLPPTlsphPRIQDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.33|      37|      61|    1467|    1504|       3
---------------------------------------------------------------------------
  992- 1015 (32.84/11.85)	.........NTASSGQGSVK...QD.GTELS..SPVSTP
 1467- 1504 (65.22/35.04)	PPkAQLPLNNTSSSGQPQSQTWTAD.GEQASGTANASTP
 1531- 1565 (53.28/24.40)	PP.ANTPAENTELSSE.QSRIGIPTvADSADGLAN..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     281.09|      91|     682|    1323|    1440|       5
---------------------------------------------------------------------------
 1323- 1440 (139.31/125.96)	LLGYDRERDFLALSPLA............LPFWeklllepyggqrdvaYVVVCP...NSTSLLAAArAFFQELS.AVYETCRLGKHR....PL.SKVSKDGFVRVgeevepekLEELDMDQWMTGPWAGQqhtDNISKL
 1979- 2090 (141.78/79.87)	LLSRDNPPEELKQQPLAlgyyvstaqttgLPHW...............FWASCPqaeNQCPLFLKA.SLHHHISiAQSEEITSDKNKrtphPLdSKTTSDVLRFV........LEQYNALSWLTCTPATQ...DRQSCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.55|      53|      55|     648|     700|       6
---------------------------------------------------------------------------
  648-  693 (70.16/32.51)	..................RFKISEERMKE...HIHTLG.LFEQPEAEPLRENG..DDPYDFKEGDIEYPF
  694-  749 (68.65/31.65)	PSSKRLK........ssgR.EPSKKAKGE...EITSNGsLPDGKDAMSIFNSA..PKSDDSSQDDAAAKT
  751-  819 (63.74/28.90)	PSLTREKdlvvnisdldnIFDEDEEELGTvypNQQSTK.LLVSTEDRPIGKEGrvSVPYPTTVADLQIMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.73|      80|     681|    1146|    1232|       7
---------------------------------------------------------------------------
 1146- 1232 (129.82/88.33)	AKQLQGVSSASS.SVMTVlqeqC...SQPISSLASlhLPQN...SSCRGRKGAL.LQ.SWMSEKQWADGSDACVDCYNALEQsLQYVDNPTGGKVD
 1832- 1920 (120.91/66.17)	ACRMCGISAADSpSILSA....ClvaMEPQGSFVV..MPDAvtmGSVFGRSTALnLQtSQLNTPQDASCTHILVFPTSATTQ.LAPSSYPTEDNND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.46|      22|     681|    1020|    1041|       8
---------------------------------------------------------------------------
 1020- 1041 (39.64/17.81)	PLSSV.EPLARPGPSLPEAHSLY
 1677- 1697 (35.70/15.25)	PVSTV.TSVLK.GPEFPTPLQLY
 1704- 1724 (32.11/12.91)	GLTRAkQP..EPGEIWAEPPPKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.60|      17|    1228|     353|     387|      11
---------------------------------------------------------------------------
  358-  377 (28.09/41.45)	PKHSGKKLTSQvvhQAWKEC
 1768- 1784 (34.51/ 7.60)	PKVSARKMGLQ...KLWEWC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.64|      14|     791|     854|     867|      16
---------------------------------------------------------------------------
  854-  867 (26.21/16.93)	HLPSLASTHLSDSR
 1647- 1660 (27.43/18.13)	HLRSLAFSCYSQSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17352 with Med13 domain of Kingdom Metazoa
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