<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17351

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTATANWVANGASLEDCHSNIFSLAELNGIKWRCYSFSGGGEYGPVISAPAQDDPVLRSFMRCVQANLLCVWRRKIKPDAKQLWIFWWGEEPNLSDVIHHELEVAEEGFWECGLSYECRTLLFKAIHNLLERCLMDKGFVRIGKWFFKPQDLEGKTLGNSEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEQHIRLAQTSATPVQVVLSPYGLSGTLTGQAYKMSDPAARKLMEDWSYFYPMVLPQKEGSGEKDQKEAGHAFDRGAHVAVDVIVGGVSMTYPAAFVLIAQADLPVEQPPLAPAVQGPNKELNNCSVPLTPPTSPEQPCSDSGFVTSASNAPTPDSSMGITSISPKHSGKKLTSQVVHQAWKECYLNQSQHTPNQQTDGTPTKEVPNGVNMWNFNDLGTRASCSCSRLKQQKVSMSATSTANPQTCASSALSSGSSLYPTSSLPKHKTSDKAEKADKQSKRPAVFPFHHRLSATQETPLEQDPPGGAQLGSLVALEPPVEPLASLPSCKYSKPLANSRKPPESLLHSPMSPLPPTLSPHPRIQDPEVLEVPVDMPVCPDGASGLGMITSETAVYTTLLRQRENGLGWWRGFRTPRTNKTDFRTPELPTDKLEDMKTETTTDGALFKRLYTQTHKRFKISEERMKEHIHTLGLFEQPEAEPLRENGDDPYDFKEGDIEYPFPSSKRLKSSGREPSKKAKGEEITSNGSLPDGKDAMSIFNSAPKSDDSSQDDAAAKTNPSLTREKDLVVNISDLDNIFDEDEEELGTVYPNQQSTKLLVSTEDRPIGKEGRVSVPYPTTVADLQIMFPTPPSLEPHPVFSPITPYRDTPSQEPPAPSGVFDHLPSLASTHLSDSRMEMEEGAVSPRQDDIKPQMGSSMFAPLSCLPSQNLPPLKIPDQCHYRPSWALLPKMEHFMTIMHPQNPAFNKDGYTNNTLTDQDYGQMSATTASVSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARPGPSLPEAHSLYLVLLLSDSVLSVFKDRNFDSCCICACNMNVKGADVGVYIPDFTCEDQYRCMCGFSAIVNRRLAHGTGLFLEDELDIFGRTSEVGQAAERRLALCRREPTVGDSRAKQLQGVSSASSSVMTVLQEQCSQPISSLASLHLPQNSSCRGRKGALLQSWMSEKQWADGSDACVDCYNALEQSLQYVDNPTGGKVDLAVVRSSAFHSWPHTNVVEMSRLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWDNIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYVVVCPNSTSLLAAARAFFQELSAVYETCRLGKHRPLSKVSKDGFVRVGEEVEPEKLEELDMDQWMTGPWAGQQHTDNISKLKLYAYAFKQQLGPQLSTLTMDSSLLLPPKAQLPLNNTSSSGQPQSQTWTADGEQASGTANASTPSGATSGQTGEANQGGSTESKGPQSSTPPANTPAENTELSSEQSRIGIPTVADSADGLANPPAIVIYIVDAFITSCGQRNETGEEDEGEEVESGSIWLLGLLRCYTEMLQNLPEAMRPALVLQVVPCQYLLQPASGENHLYLQHLRSLAFSCYSQSRRLLPQQTHIKSLTGFGPVSTVTSVLKGPEFPTPLQLYSPPFILGLTRAKQPEPGEIWAEPPPKYNVLFVGYCLSHDQRWILVSCTDQQGELLETCIINIDVPNRSRRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWTSLLGEHSLQSIGRQLREACRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSATTQLAPSSYPTEDNNDDMFDLPFPDELENDIGHDMMLITNLHPSPNPSPVPSPGSPSGMGMGSHFHHTRSQGERLLSRDNPPEELKQQPLALGYYVSTAQTTGLPHWFWASCPQAENQCPLFLKASLHHHISIAQSEEITSDKNKRTPHPLDSKTTSDVLRFVLEQYNALSWLTCTPATQDRQSCLPVHLAVLIQMYNAILNML
Length2107
PositionMiddle
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy-0.419
Instability index57.18
Isoelectric point5.56
Molecular weight231310.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17351
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     866.81|     164|     164|     305|     468|       1
---------------------------------------------------------------------------
  160-  302 (136.82/65.91)	........................................SEHLSCSFSF.F..LHGESNVCT...SVEI..AQHQP....................AYHITEQHIR....L..AQTSATPV.QVVlsPYGLsgtltgqaykmsdpaarKLmedWSYFY....PM...VLPQKEGS.GEKDQKEAGH.AFDRG..AHVAVDV.IVGG.VSMtYPAAFVLIAQADL.PVEQPP
  305-  468 (277.37/142.80)	PAVQGPNKELNNCS.................VPLTP..PTSPEQPCSDSG.F..VTSASNAPTPDSSMGI..TSISPKHSGKKLTSQVVHQAWK..ECYLNQSQHTP....N..QQTDGTPT.KEV..PNGV.................NM...WNFND....LG...TRASCSCS.RLKQQKVSMS.ATSTANPQTCASSA.LSSG.SSL.YPTSSLPKHKTSD.KAEKAD
  474-  629 (160.62/78.93)	PAVFPFHHRLSATQetpleqdppggaqlgslVALEP..PVEPLASLPSCK.Y..SKPLANSRKPPESLLH..SPMSP....................LPPTLSPH.P....R..IQ.D.PEV.LEV..P..V.................DM...PVCPDgasgLGmitSETAVYTT.LLRQRENGLGwWRGFRTPRTNKTD...........FRTPELPTDKLEDmKTE...
  631-  743 (113.79/53.31)	..............................................................TTDGALF............KRLYTQ.THKRFKisEERMKEHIHTL....GlfEQPEAEPL.RE....NGD.................DP...YDFKE....GD...IEYPFPSSkRLKSSGREPS.KKAKGEEITSNGS..LPDGkDAM.SIFNSAPK...SD.DSSQDD
  821-  975 (178.21/88.55)	PPSLEPHPVFS.....................PITPyrDTPSQEPPAPSGvFdhLPSLASTHLSDSRMEMeeGAVSPRQDDIKPQMGSSMFAPL..SCL..PSQNLPplkiP..DQCHYRPSwALL..P....................KM...EHFMT....IM...HPQNPAFN...KDGYTNNT.LTDQDYGQMSATTAsVSTT.TGI.LPSPATPR............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     174.79|      38|      61|    1466|    1503|       2
---------------------------------------------------------------------------
  981- 1014 (51.75/24.58)	PRTPRTPRGiNTASSGQGSVK...QD.GTELS..SPVSTP
 1466- 1503 (69.91/36.17)	PPKAQLPLN.NTSSSGQPQSQTWTAD.GEQASGTANASTP
 1530- 1564 (53.13/25.46)	PP.ANTPAE.NTELSSE.QSRIGIPTvADSADGLAN..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.07|      57|      61|    1923|    1983|       3
---------------------------------------------------------------------------
 1927- 1983 (106.16/51.23)	PDELEND...IGH..DMMLITNL.HPSPNPSPVPSPGSPSGMGMGSHFHHTRSQGERLLSRDN
 1985- 2047 (88.92/35.26)	PEELKQQplaLGYyvSTAQTTGLpHWFWASCPQAENQCPLFLKASLHHHISIAQSEEITSDKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     623.04|     202|     629|    1019|    1258|       4
---------------------------------------------------------------------------
 1019- 1258 (296.76/293.57)	PLSSVEPLARpGPSLPEAHSLYlvllLSDSVLSVFKDRNFDSCCICAcnmnvkgadvgvyipdftcEDQYRCMCGFsaiVNRRLAHGTGLFLEDELDIFGRTSE...VGQAAERRlalcRREPTVgDSRAKQLQGVSSASSSVMTVLQEQCSQPISSLASL.H..LPQNSSCRGRKGalLQSwmSEKQWADGSDAC....VDCYNALEQSLQYVDnPTGGKVDL..AVVRSSAFHSWPHTNvVEMSRLSS.QD
 1676- 1890 (326.28/222.17)	PVSTVTSVLK.GPEFPTPLQLY....SPPFILGLTRAKQPEPGEIWA...................EPPPKYNVLF...VGYCLSHDQRWILVSCTDQQGELLEtciINIDVPNR....SRRPKV.SARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLgHgeLKDWTSLLGEHS..LQS..IGRQLREACRMCgisaADSPSILSACLVAME.PQGSFVVMpdAVTMGSVFGRSTALN.LQTSQLNTpQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.89|      19|      70|    1504|    1522|       5
---------------------------------------------------------------------------
 1504- 1522 (32.85/19.89)	SGATSGQTGEANQGGSTES
 1577- 1595 (34.05/20.92)	SCGQRNETGEEDEGEEVES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.77|      13|    1147|     779|     791|       6
---------------------------------------------------------------------------
  779-  791 (22.29/12.93)	VYPNQQSTKLLVS
 1898- 1910 (22.48/13.11)	VFPTSATTQLAPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.14|      26|     655|    1393|    1439|       7
---------------------------------------------------------------------------
 1334- 1368 (36.27/34.06)	LSPLALPFWeklLLEPYGGQRDVayvvvcPNSTSL
 1414- 1439 (49.86/17.95)	LEELDMDQW...MTGPWAGQQHT......DNISKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17351 with Med13 domain of Kingdom Metazoa
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