<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17346

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELAYVCEWDKRPKSTHCPSIPLVCSWSCRNLVAFTTDLKSEDDDKDVSHMIHIIDTEHPWDVFSINSGHSEVISCLEWDQSGSRLLSADGDGQIRCWSMSDHLVNSWETNLSSSVDGDPIVALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFTPSLILFGGKPMEGWLAVTVSGLVTVSLLKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPIQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPMRRDKYTAVTHLKFLTRENSEQVLLCASNQSGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTSDLERVSAIALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGSIQILHRLSLHTMGVFHGSTSSAQRPGDETAIKRQRTTGPALHFKALQFSLTSLALAGVDNHGKLYMLRVSPSMGQVLDMNTTLRHLLFLLEYCMVTGHDWWDVLLHVQPSMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSMVRPGFGFMRDGASLGMLREMLVMIRIWGLLKPGCLPTFTA
Length670
PositionTail
OrganismAustrofundulus limnaeus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Rivulidae> Austrofundulus.
Aromaticity0.07
Grand average of hydropathy0.037
Instability index37.49
Isoelectric point7.08
Molecular weight73919.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17346
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.42|      14|      79|      18|      32|       1
---------------------------------------------------------------------------
   18-   32 (27.49/17.60)	CPSIP..LVCSWSCrNL
   97-  112 (24.93/11.23)	CWSMSdhLVNSWET.NL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.37|      57|     476|     117|     186|       4
---------------------------------------------------------------------------
  117-  186 (76.72/101.11)	DGDPIVALSWLHNGV.KLALHVeMSGSTNFGekfSRVKftPSlilFG....GKPMeGWLAvtvSGLVTV...SLLKPG
  599-  663 (89.65/68.09)	DGPPLQSLQQLIQWVgDFVLYL.LANLPNQG...SMVR..PG...FGfmrdGASL.GMLR...EMLVMIriwGLLKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.16|      22|     154|     202|     224|       5
---------------------------------------------------------------------------
  202-  224 (33.44/24.68)	RVAlADIAFTGGGNIVVAATDGS
  359-  380 (40.73/25.78)	KVA.SDTKFCPGLGLALAFHDGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.94|      22|     417|      43|      64|       6
---------------------------------------------------------------------------
   43-   64 (42.65/26.33)	DDDKDVSHMIHIID....TEHPW.DVF
  458-  484 (30.29/16.77)	DMNTTLRHLLFLLEycmvTGHDWwDVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.84|      33|      97|     425|     457|      10
---------------------------------------------------------------------------
  425-  457 (56.15/43.90)	ALQFSLTSLALA....GVDNHGKLYMLRVSPSMGQVL
  520-  556 (47.69/36.02)	AVKASLCKLSTAtaarACDFHAKLLLIAISSTLKSLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17346 with Med16 domain of Kingdom Metazoa
Unable to open file!