<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17341

Description MED12 isoform 3
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSENERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDAEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2177
PositionKinase
OrganismPan troglodytes (Chimpanzee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.513
Instability index57.52
Isoelectric point6.63
Molecular weight243093.73
Publications
PubMed=16136131

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17341
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     189.72|      15|      15|    2051|    2065|       1
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 2051- 2065 (36.49/14.87)	QQQQQQ....QQQ....QQQQQQ
 2068- 2086 (30.89/11.43)	QQQQQQ....QQQyhirQQQQQQ
 2088- 2102 (33.19/12.84)	LRQQQQ....QQQ....QQQQQQ
 2103- 2117 (35.84/14.46)	QQQQQQ....QQQ....QQQQHQ
 2118- 2132 (30.08/10.94)	QQQQQQ....AAP....PQPQPQ
 2133- 2151 (23.22/ 6.73)	SQPQFQrqglQQT....QQQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.19|      13|      18|     349|     363|       2
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  349-  363 (21.63/14.34)	LLMCPQhrPLVFGLS
  370-  382 (28.56/12.81)	LLCCPS..ALVWHYS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     528.76|     142|     231|    1625|    1776|       3
---------------------------------------------------------------------------
 1485- 1562 (58.95/21.02)	VLTC.............LKGQDE..QREGLLTSlysqVHQIVNNWRddqylddckpkqlMHEALKLRLNLVGGMFDT..VQRSTQQTTEWAMLLL...........................................................................................
 1648- 1802 (241.72/119.07)	VITCEPQGSLIDTKGNKIAGFDSIfKKEGLQVS....TKQKISPWD.............LFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYH......THLRPRPRA..YYLEP..LPLPPEDE..EPPA.PTLLEPEKKAPEPPKTDKPGAAPpsteerkkkstkGKKRSQPATKT.EDY
 1803- 1901 (95.84/46.24)	..............................................................GMGPGRS...GPYG.VTVPPD..........LLHHpnpgsiTHLNYRQGSigLYTQN..QPLPAGGPrvDPYR.PVRL.PMQKLPTRP..TYPGVLP.....ttmtgvmGLEPSSYKTSVyRQQ
 1914- 2004 (132.25/59.76)	QLQ.QSQGMLGQSSVHQMTPSSSY....GLQ......TSQGYTP.............................YVSHVGL.........QQ.....H......TG....PAG..TMVPPsySSQPYQST..HPSTnPTLVDPTRHLQQRPSGYVHQQAP...........................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.43|     109|     231|     216|     335|       4
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  216-  335 (167.10/126.95)	GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShvISAQSTSTlPTTPAPQ
  450-  567 (169.33/99.53)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS..IASGSLSA.PSAPIFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     266.10|      85|     231|     745|     844|       6
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  745-  844 (128.98/115.20)	SCSHECNQrlvvlFgvGKQRDDARHAIKK.ITKDIL.KVLNRKGTAE..TDQLApivplNPGDLTFLGGEDGQKRRRNRPEAFPTaedIFAKFQH..LSHYDQHQV
  981- 1071 (137.12/87.01)	SCSHLKNK.....F..GELFSDFCSKVKNtIYCNVEpSESNMRWAPEfmIDTLE.....NPAAHTFTYTGLGKSLSENPANRYSF...VCNALMHvcVGHHDPDRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.84|      23|     231|     386|     411|       7
---------------------------------------------------------------------------
  386-  411 (39.55/20.66)	SR..IKTGSPldhLPIAPSNLPMP.........EGNS
  620-  653 (34.29/11.87)	SRgdLAFGAP...GPRPPSPFDDPaddaehkeaEGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.56|      33|     202|    1073|    1105|       8
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 1073- 1105 (61.57/41.09)	DIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNN
 1267- 1306 (49.98/31.88)	NISVETASLDVYAKYVlrsicQQEWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.64|      32|     202|    1233|    1266|       9
---------------------------------------------------------------------------
 1233- 1266 (52.83/39.35)	AELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR
 1433- 1467 (46.82/27.75)	AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     853|     867|      11
---------------------------------------------------------------------------
  853-  867 (26.85/17.21)	LEQITSFALG.MSYHL
  869-  884 (23.14/13.77)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.46|      22|     202|     912|     937|      12
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  912-  937 (29.83/34.92)	SDLvgSYTTSLClCIVAVLRHYHaCL
 1120- 1141 (39.62/25.91)	SDL..SFHDSLA.TFVAILIARQ.CL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      14|      15|    1328|    1342|      13
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 1328- 1342 (22.34/18.38)	HRLLDNEDgENPQRQ
 1345- 1358 (26.58/16.17)	KRILQNLD.QWTMRQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17341 with Med12 domain of Kingdom Metazoa
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