<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17329

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQVEIVVLFIFSFTLSDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSENERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDAEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVNWVGDSME
Length2182
PositionKinase
OrganismPan troglodytes (Chimpanzee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.478
Instability index56.22
Isoelectric point6.48
Molecular weight243262.22
Publications
PubMed=16136131

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17329
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     197.96|      16|      16|    2068|    2083|       1
---------------------------------------------------------------------------
 1922- 1937 (21.59/ 7.38)	GQRLRQQLQAKIQ..SQG
 2071- 2087 (32.88/15.91)	QQQQQQQQQQQQQ.qQQQ
 2088- 2100 (20.04/ 6.20)	QQQQQQYH.....irQQQ
 2101- 2116 (31.88/15.15)	QQQILRQQQQQQQ..QQQ
 2117- 2132 (37.28/19.23)	QQQQQQQQQQQQQ..QQQ
 2133- 2148 (30.97/14.46)	HQQQQQQQAAPPQ..PQP
 2149- 2164 (23.33/ 8.69)	QSQPQVAAGLQPQ..AQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     672.70|     177|     206|    1241|    1446|       2
---------------------------------------------------------------------------
 1048- 1211 (206.84/113.65)	FTYTGLGKSLSENPANR.YSfvcnalmhvcVGHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNN.............................................GTCGFNDLLCNVDVSDLSfHDSLATFVAILIA.......RQCL....LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRILLHLFKT.PQLNPCQSDG...NKPTV
 1254- 1446 (277.55/209.25)	FTVTGGTEELPEEEGGG.GS..........GGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDL.....QDPVLSSaqaqrlmqliCYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMR.QSSLELQLMIKQT....PNNEMNS....LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTkPVLSSLERSGvwlVAPLI
 1460- 1633 (188.31/103.69)	....AAGEEL..EKGQHlGS..........SSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIvnnwrDDQYLDD..........CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAM.....LLLEIIISGTvdmqSNNELFTtvldMLSVLIN.GTLAADMSSI..SQGSMEEN..KRAYMNLAKK....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.76|      16|      19|    1753|    1768|       3
---------------------------------------------------------------------------
 1753- 1768 (31.83/14.88)	L....EPLPLPPEDEEPPA.P
 1855- 1874 (20.90/ 6.83)	LytqnQPLPAGGPRVDPYR.P
 1879- 1893 (20.03/ 6.19)	M....QKLPTRP..TYPGVlP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.04|      18|      19|    1963|    1981|       4
---------------------------------------------------------------------------
 1963- 1981 (30.44/18.89)	PYVSHVGLQQhTGPAGTMV
 2031- 2048 (29.85/13.45)	QRFSHQTLQQ.TPMISTMT
 2049- 2064 (22.75/ 8.30)	P.MSAQGVQ..AGVRSTAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1674|    1692|       5
---------------------------------------------------------------------------
 1674- 1692 (14.83/26.85)	TKgNKIAGFDsIFkkEGLQ
 1695- 1709 (30.03/21.39)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.86|      16|     353|     343|     359|       6
---------------------------------------------------------------------------
  343-  358 (31.20/11.67)	PTTPAPQPPTSSTPST
 1982- 1997 (30.65/11.24)	PPSYSSQPYQSTHPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.13|      13|      14|     869|     881|       8
---------------------------------------------------------------------------
  869-  881 (23.83/18.77)	QITSFALG.MSYHL
  885-  898 (20.30/14.62)	QHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     304.81|     102|     229|     527|     638|       9
---------------------------------------------------------------------------
  527-  638 (144.13/135.17)	SCKRSGRHRAMVVAKLLEKR.QAEIEAERCGES..EAADEKGSIASGSLsAPSAPIfQDVLLQFLDTQApmlTDPRSENeRVEFF....NLVLLFCELIRHDvfSHNMytCTLISRGDL
  759-  867 (160.68/111.44)	SCSHECNQRLVVLFGVGKQRdDARHAIKKITKDilKVLNRKGTAETDQL.APIVPL.NPGDLTFLGGED...GQKRRRN.RPEAFptaeDIFAKFQHLSHYD..QHQV..TAQVSRNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     105.63|      22|     229|    1769|    1790|      10
---------------------------------------------------------------------------
  645-  675 (29.71/13.87)	PRP........PSPfddpaddaeHKEAEG.......SSS.SKLEDPG
 1769- 1787 (28.08/12.62)	...........TLL.........EPEKKA.......PEP.PKTDKPG
 1788- 1817 (25.55/10.69)	AAP........PST.........EERKKKstkgkkrSQPaTKTEDYG
 1818- 1841 (22.29/ 8.19)	MGPgrsgpygvTV...........P...........PDL.LHHPNPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17329 with Med12 domain of Kingdom Metazoa
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