<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17289

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLMPRNPCLFPKIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLVKFQLIVFLMVFNHLFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSDVVSFLTVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1375
PositionTail
OrganismPan troglodytes (Chimpanzee)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.148
Instability index52.28
Isoelectric point9.12
Molecular weight151530.64
Publications
PubMed=16136131

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17289
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     224.59|      60|      64|     923|     984|       1
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  923-  954 (49.47/12.09)	...........................................................PPPQQQPFPKQPGTSGAYPL.TSPPTSYHSTVN
  956- 1021 (93.25/31.34)	SPSMMHTQSPGNlHAASSPSGALRAP..SPA.......................sfvptPPPSSHGISIGPGASFASPHgTLDPSSPYTMV.
 1022- 1104 (81.88/22.69)	SPSGRAGNWPGS.PQVSGPSPAARMPgmSPAnpslhspvpdashspragtssqtmptnmPPPR.....KLPQRSWAASI...PTILTHSALN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.65|      23|      28|     223|     245|       2
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  223-  245 (35.56/24.25)	RLLKLEILVEDKETGDGRALVHS
  253-  275 (40.09/28.33)	QLVQSRLFADEKPLQDMYNCLHS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.28|      42|     594|     553|     619|       3
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  553-  596 (59.47/31.97)	LQQFKENIQDLVFRTKtGkQTRTNAKRKLSDDPCPVESKKTKRA
  624-  665 (69.80/67.99)	LELSNLEIPHQGVQVE.G.DGFSHAIRLLKIPPCKGITEETQKA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.81|      56|     154|     676|     740|       5
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  676-  734 (66.79/61.40)	..........RLQGRNNRTWVAELVFAncPLNGTST........................reqgpsRHVYLTYENLlSEPVGGRKVVEMF..LND
  735-  795 (29.83/12.86)	WNSIAR..............................lyecvlefarslpdipahlnifsevrvynyRKLILCY....GTTKGSSDVVSFLtvLFD
  800-  842 (53.18/28.55)	LNAINKlptvPMLGLTQRTNTAYQCFS..ILPQSST...............................HIRLAFRNM...................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     482.35|     151|    1079|      28|     187|       6
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   28-  131 (140.03/77.83)	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PAPPPPGAAVAAAAAA....AASP.....GYRLMPRNPC..LFPKIVQFASRTRQLF.VRLLALVKWANNAgKVEKCAMISSFLDQQAILFVDTADRLASLA..RDAL.VHARLPSFAI
  132-  187 (27.02/26.79)	PYAIDVLTtgSYPRL...PTCI.RDKIippdPITKIE...KQATlhQLNQILRHRL.VTTDLPP................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1109- 1210 (111.02/56.39)	................................................................qlanltvangrvkfrvegefeatltvmgddpdvpwrllkleilvedketgdgralvhsmqisfihqlvqsrlfadekplqdmynclhsfclslqlevlhsqtlmlirerwgdlvqveryhagkclslsvwnqqvlgrktgtasvhkvtikidendvskplqifhdpplpasdsklveramkidhlsiekllidsvharahqklqelkailrgfnanenssietalpalvvpilepcgnseclhifvdlhsgmfqlmlyglvkfqlivflmvfnhlfwlgqqrckqsikhlptissetlqlsnysthpignlsknklfikltrlpqyyivvemlevpnkptqlsykyyfmsvnaadredspamalllqqfkeniqdlvfrtktgkqtrtnakrklsddpcpveskktkragemcafnkvlahfvamcdtnmpfvglrlelsnleiphqgvqvegdgfshairllkippckgiteetqkaldrslldctfrlqgrnnrtwvaelvfancplngtstreqgpsrhvyltyenllsepvggrkvvemflndwnsiarlyecvlefarslpdipahlnifsevrvynyrklilcygttkgssdvvsfltvlfdtqaplnainklptvpmlgltqrtntayqcfsilpqssthirlafrnmycidiycrsrgvvairdgayslfdnsklvegfypapglktflnmfvdsnqdarrrsvneddnppspiggdmmdslisqlqpppqqqpfpkqpgtsgaypltspptsyhstvnqspsmmhtqspgnlhaasspsgalrapspasfvptpppsshgisigpgasfasphgtldpsspytmvspsgragnwpgspqvsgpspaarmpgmspanpslhspvpdashspragtssqtmptnmppprklpqrswaasiptilthsalnilllPS.PTPGLVPGLAGSY....LCSPlerflGSVIMRRH.....LQRIIQ..QETLQLInSNEPGVIMFKTDA...LKCRVALSPKTNQTLQLKVTPENAGQWK..PDELqVLEKFFETRV
 1214- 1374 (204.28/114.43)	PFKANTLI..AFTKLlgaPTHIlRDCV....HIMKLElfpDQAT..QLKWNVQFCLtIPPSAPP.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................iaP.PGTP..AVVLKSKMlfflQLTQ.....KTSVPPQEPVsiIVPIIYDMASGTTQ......QADIPRQQNS.SVAAPMMVSNILKRFAEMNPPRQGECTIFAavRDLM.ANLTLPPGGR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.80|      52|      63|     407|     461|       7
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  407-  461 (81.07/67.47)	SIEtALPALVVPILEPCGNSecLHIFVDLHSGMFQLMLYGLVKFQLIV.FLMVFNH
  473-  525 (83.73/57.28)	SIK.HLPTISSETLQLSNYS..THPIGNLSKNKLFIKLTRLPQYYIVVeMLEVPNK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17289 with Med14 domain of Kingdom Metazoa
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