<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17250

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQVGIVVLFIFSFTLSDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVFLRAFVLFPRVNDIAILAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSGPRLRGRKEKRQAWGRIKLGSLNCIFYFHLTDLLWPWQVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVATGLEPQAQGQLPRLGMQPVNWVGDSME
Length2145
PositionKinase
OrganismPapio anubis (Olive baboon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Papio.
Aromaticity0.07
Grand average of hydropathy-0.472
Instability index56.71
Isoelectric point6.93
Molecular weight239322.08
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17250
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     164.51|      16|      16|    2030|    2045|       1
---------------------------------------------------------------------------
 2030- 2045 (37.35/15.73)	QQQQQQQQQQQQQQQQ
 2047- 2061 (25.65/ 8.52)	QQQQQQQQQYHIRQQ.
 2062- 2077 (32.88/12.98)	QQQQILRQQQQQQQQQ
 2078- 2093 (37.35/15.73)	QQQQQQQQQQQQQQQQ
 2094- 2108 (31.28/11.99)	QQHQQQQQQQ.AAPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.52|      18|      19|    1709|    1726|       2
---------------------------------------------------------------------------
 1709- 1726 (34.57/15.37)	PRAYYLEP...LPLPPEDEEP
 1727- 1747 (25.95/ 9.47)	PAPTLLEPekkAPEPPKTDKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.44|      36|     353|     321|     359|       3
---------------------------------------------------------------------------
  324-  359 (63.71/37.30)	DGVSS..HSSHVISAQST....SSLPTTPAPQPPTSSTPST...P
 1920- 1960 (62.23/29.60)	QGYTP..YVSHVGLQQHTgpagTMVPPSYSSQPYQSTHPST..nP
 1987- 2027 (38.51/16.44)	.GLTStqRFSHQTLQQ.TpmisTMTP..MSAQGVQAGVRSTailP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.67|      47|     353|    1412|    1479|       4
---------------------------------------------------------------------------
 1238- 1272 (44.86/16.44)	AELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGRN...............................................................................................................................................................
 1412- 1425 ( 5.65/ 6.91)	......................................isvetasldvyakyvlrsicqqewvgerclkslcedsndlqdpvlssaqaqrlmqlicyphrlldnedgenpqrqrikrilqnldqwtmrqsslelqlmikqtpnnemnslleniakatievfqqsaetgssgstasnmPSSSKTKP......VLSSLE
 1437- 1499 (58.16/46.50)	AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDRQ....................................................................................................................................kqksgprLRGRKEKRqawgriKLGSLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.63|      25|     233|    1875|    1899|       6
---------------------------------------------------------------------------
 1819- 1841 (33.96/13.69)	QNQPLPAGGPRVDPYRPVRLPMQ..
 1875- 1899 (43.07/19.53)	QQQPAVPQGQRLRQQLQAKIQSQGM
 2112- 2134 (39.60/17.31)	QSQPQVATG..LEPQAQGQLPRLGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     350.06|     115|     233|     527|     651|       7
---------------------------------------------------------------------------
  527-  651 (171.34/161.07)	SCKRSGRHRAMVVAKLLEKR.QAEIEAERCGES..EAADEKGSIASGSLsAPSAPIfQDVLLQFL...DTQAPMLTDPRSESERVEFFNlvlLFCELIRHDvfSHNMytCTLISRGDL....AFgAPGPRPPSPF
  759-  883 (178.72/130.13)	SCSHECNQRLVVLFGVGKQRdDARHAIKKITKDilKVLNRKGTAETDQL.APIVPL.NPGDLTFLggeDGQKRRRNRPEAFPTAEDIFA...KFQHLSHYD..QHQV..TAQVSRNVLeqitSF.ALGMSYHLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      16|    1333|    1347|      13
---------------------------------------------------------------------------
 1333- 1347 (21.57/16.98)	HRLLDNEDgENPQRQ
 1350- 1363 (26.45/15.46)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      18|    1638|    1655|      14
---------------------------------------------------------------------------
 1638- 1655 (18.50/20.52)	NKIAGFDsIFkkEGLQVS
 1658- 1672 (30.32/18.61)	QKISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.43|      22|      23|    1527|    1549|      15
---------------------------------------------------------------------------
 1527- 1549 (32.46/34.79)	QQTTEwAMLLLEIIISGTV..DMQS
 1552- 1575 (31.98/25.39)	ELFTT.VLDMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.44|      10|      18|     366|     377|      16
---------------------------------------------------------------------------
  366-  377 (16.13/14.31)	CPQhrPLVFGLS
  387-  396 (22.31/11.69)	CPS..ALVWHYS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17250 with Med12 domain of Kingdom Metazoa
Unable to open file!