<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17247

Description Transducin beta like 1 X-linked
SequenceMTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQAAAAAASAAAAAAATTSASVSQQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVSNTSGWLESGVLGAADAEVSFEGMCSVRVLKGLAQCQRKLLGWIPSELVPHLGMAFSLSLPECPSSQHFLSQIVGSQPG
Length645
PositionTail
OrganismPapio anubis (Olive baboon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Papio.
Aromaticity0.07
Grand average of hydropathy-0.270
Instability index41.07
Isoelectric point5.93
Molecular weight69636.08
Publications









Function






Annotated function


GO - Cellular Component
histone deacetylase complex	GO:0000118	IEA:Ensembl
mitotic spindle	GO:0072686	IEA:Ensembl
transcription repressor complex	GO:0017053	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:Ensembl
histone binding	GO:0042393	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
transcription factor binding	GO:0008134	IEA:Ensembl
transcription regulatory region sequence-specific DNA binding	GO:0000976	IEA:Ensembl

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:Ensembl
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:Ensembl
proteolysis	GO:0006508	IEA:Ensembl
sensory perception of sound	GO:0007605	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17247
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     352.87|      39|      39|     382|     420|       1
---------------------------------------------------------------------------
  262-  296 (44.07/23.25)	NGGSTQLVLR...HCirEGGHDVP..S....NKDVTSLDWNTNG
  300-  337 (59.36/33.80)	ATGSYDGFAR...I...WTEDGNLASTLGQHKGPIFALKWNRKG
  382-  420 (68.11/39.84)	ASCSTDMCIH...VC..RLGCDRPVKTFQGHTNEVNAIKWDPSG
  424-  462 (65.50/38.04)	ASCSDDMTLK...IW..SMKQEVCIHDLQAHNKEIYTIKWSPTG
  475-  513 (50.50/27.69)	ASASFDSTVRlwdIE..RGVC...IHTLTKHQEPVYSVAFSPDG
  517-  554 (65.33/37.92)	ASGSFDKCVH...IW..NTQSGNLVHSYRG.TGGIFEVCWNARG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.84|      11|      39|     571|     581|       4
---------------------------------------------------------------------------
  571-  581 (21.32/12.80)	GWLESGV...LGAA
  608-  621 (17.52/ 9.17)	GWIPSELvphLGMA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17247 with Med16 domain of Kingdom Metazoa
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