<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17244

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQTRPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVWGREVRAMPSSFRQCKYATVKK
Length2139
PositionKinase
OrganismPapio anubis (Olive baboon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Papio.
Aromaticity0.07
Grand average of hydropathy-0.396
Instability index56.08
Isoelectric point7.15
Molecular weight239491.30
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17244
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     538.66|     173|     201|    1676|    1876|       1
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 1676- 1875 (264.21/209.24)	GSLIDTKGnKIAGFDSIDKKQG..LQ......VSTKQKVSPWDLFEGQKNPAPLSWAwfgtvrvDRRVIK...YEEQHHLLLYHTHPMPKPRS....YYLQPLPLPpeeeeeeptsPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYrvPPNYS.PISSQMMHHPQSTLWGYnlVGQPQQPgfFLqnQSLTpGGSRLD
 1878- 2066 (274.45/153.71)	GSFVPTNT.KQALSNMLQRRSGamMQppslhaITSQQQLIQMKLLQQQQQQRLLRQA.......QTRPFQqdfCNSAVSLLEDFDNIMGQPGDqaalFAAQTRPSP..........QLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAY..PAAHSnPVLMERLRQIQQQPSGY..VQQQASP..YL..QPLT.GSQRLN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     489.07|     160|     203|     909|    1109|       2
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  909- 1107 (258.08/281.31)	SYTTGLCVCIVAVLRRyhsclilnpdqtaQVFeGLCGVVKHVVNPS....ECSSPER.......C.ILAYLYDLYVSCsHLRSKFGDLFS...SACSKVKQTIYNNVMPANSNLRWDPDFMM..DF.IENPSARSI...NYSMLGkiLSDNaanrysfvcntlmnvcmghqdaGRINDIANFSSELTACCTVLSSEWLG.......VLKALCCS...SNHVWGFNDVLCT
 1114- 1304 (230.99/166.26)	SFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPSllaaACGDADAepgarmtCrLLLHLFRAPQAC.FLPQATGKPFPgirSSCDRHLLAAAHNSIEVGAVFAVLKAIMMlgDAkIGNNSVSSLkndDFTMRG..LRCD......................GNADDIWTASQNPKSCGKSISIETANlreyaryVLRTICQQewvGEHCLKEPERLCT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.34|      23|      35|    1313|    1335|       3
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 1313- 1335 (41.58/26.65)	VLSNMQAQKLLQ.LICYPHGIKEC
 1349- 1372 (37.76/23.44)	ILQNLEQWTLRQsWLELQLMIKQC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     244.58|      59|     203|    1378|    1457|       5
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  308-  365 (70.00/34.92)	...DSPNLLAAHSPHM.MIGPNnsSIGAPSPGppgpgmSPVQLAFSDFLSCAQH......GPLVYGLS
  380-  431 (79.81/39.02)	VWNYSTNENKSANPG....SPL..DLLQVAPS......SLPMPGGNTAFNQQVRARIYEVEQQI....
 1398- 1457 (94.77/86.55)	VFQQSADLNNSSNSGMsLFNPN..SIGSADTS......STRQNGIKTFLSSSERRGVWLVAPLIARLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.15|      32|     159|     542|     603|      11
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  548-  584 (45.25/58.76)	EVLDEKESISSsslaGSS..LPVFQNVLLRFlDTQAPSL
  843-  876 (50.90/14.47)	NVLEQITSFAS....GTSyhLPLAHHIQLIF.DLMEPAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17244 with Med12 domain of Kingdom Metazoa
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