<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17243

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQVPGPLFLLLASLLQCEPWAGISHDPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRLALPGPHPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length736
PositionTail
OrganismPapio anubis (Olive baboon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Papio.
Aromaticity0.04
Grand average of hydropathy-0.582
Instability index78.79
Isoelectric point9.30
Molecular weight80863.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17243
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.95|      18|      21|      76|      95|       5
---------------------------------------------------------------------------
   76-   93 (35.49/11.46)	QSLTGGPAAGAAGIGMPP
   98-  113 (25.91/ 8.01)	QSLGGMGSLGAMGQPM..
  115-  128 (23.55/ 6.71)	..LSGQPPPGTS..GMAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     216.85|      41|     118|     293|     333|       6
---------------------------------------------------------------------------
  244-  268 (33.17/ 6.19)	DPP...MQqP.......QP..PPTQA.....LPQ.QLQ...QMH.........HP...............
  293-  327 (57.44/16.73)	..........QSQ...TQPLVSQAQA.....LPG.QML...YTQ.........PPLKFV..RAP..MVVQ
  328-  382 (42.05/10.05)	QPP...VQ.PQVQ...QQTAVQTAQA.aqmvAPGvQMIteaLAQggmhirarfPPTTAV..SA.....VP
  414-  452 (45.80/11.67)	QPG...SQ.PNSN...VRL......A.....LPG.PHP...SPQ.........PSQSPVtaRTPqnFSVP
  551-  598 (38.39/ 8.46)	TPPpppVP.PTKQqylCQPLLDAVLAnirspVFN.HSL...YRT.............FV..PAM..TAIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.56|      21|      28|     474|     496|       8
---------------------------------------------------------------------------
  474-  495 (31.70/26.91)	QAEEQQYLDKLKQL.......SKYIePLR
  504-  531 (29.86/14.79)	NEDRKKDLSKMKSLldiltdpSKRC.PLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.48|      18|     442|     209|     227|       9
---------------------------------------------------------------------------
  209-  227 (31.31/17.73)	HLI.KLHHQNQQQVPgPLFL
  653-  671 (29.18/11.96)	HLIcKLDDKDLPSVP.PLEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17243 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTAT
2) PWAGISHDPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
3) RAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRLALPGPHPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
74
237
321
138
308
486










Molecular Recognition Features






MoRF SequenceStartStop




1) MHIRAR
366
371