<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17216
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQPGQAGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQMAQASQPGKMPSGIKTNIKSASMHPYQR |
Length | 268 |
Position | Head |
Organism | Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae>
Nomascus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.549 |
Instability index | 45.42 |
Isoelectric point | 6.92 |
Molecular weight | 29109.63 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP17216
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.96| 13| 17| 198| 210| 1
---------------------------------------------------------------------------
198- 210 (26.14/14.15) GSSGPGQPGQAGA
216- 228 (22.82/11.48) GTSGLQQVQMAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.41| 19| 27| 67| 86| 2
---------------------------------------------------------------------------
67- 86 (29.90/29.65) KTPLFRNQViIP..LVLSPDRD
96- 116 (30.51/24.07) RVPVFSHEV.VPdhLRTKPDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.07| 15| 35| 12| 26| 3
---------------------------------------------------------------------------
12- 26 (25.08/16.03) LD..ALLS.QVADLKNSL
46- 63 (16.00/ 8.05) LDsfALLSgQLNTLNKVL
---------------------------------------------------------------------------
|