<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17213

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGMMGIVRTCRSEIFKKWNSFLCPRPYLNPPSLSFGLQISSDDDAVVSIAIVLGRHRDMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSLFCPISLFLDEKLMGLRFCGARFFLRAFVLFPRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVNWVGDSME
Length2109
PositionKinase
OrganismNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae> Nomascus.
Aromaticity0.07
Grand average of hydropathy-0.469
Instability index57.49
Isoelectric point7.06
Molecular weight235327.06
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17213
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     168.23|      16|      16|    1995|    2010|       1
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 1995- 2010 (37.69/15.42)	QQQQQQQQQ.....QQQQQQQ
 2024- 2039 (34.03/13.19)	QQQQQQILR.....QQQQQQQ
 2040- 2055 (37.69/15.42)	QQQQQQQQQ.....QQQQQQQ
 2056- 2071 (34.44/13.45)	QQQQHQQQQ.....QQQAAPP
 2072- 2092 (24.37/ 7.31)	QPQPQSQPQvaaglQPQAQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.66|      15|      15|     959|     973|       2
---------------------------------------------------------------------------
  959-  973 (27.98/15.92)	LYDLYTSCS.HLKNKF
  976-  991 (22.68/11.53)	LFSLFCPISlFLDEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     655.72|     149|     233|    1566|    1717|       3
---------------------------------------------------------------------------
 1390- 1570 (129.81/56.48)	EELEKG.QHLGS.SSRKERDrqkqksmsLLSQQPFLSLVLT...CLKGQDE..Q.....REGLLTSlysqVHQIVN.NWrdDqylddckpkqlMHEALKLRLNLVGGMFDTVQ..RSTQQTTEWAMLLLeiiisgtvdmqsnnelfttvldmlsvlingtlaadmssiSQGSMEENKRAYMN....LA..KKLQKELGE..........................................rQS
 1571- 1734 (248.85/122.53)	DSLEKV.RQLLP.LPKQTRD........VITCEPQGSLIDTKGnKIAGFDSIFK.....KEGLQVS....TKQKIS.PW..D...........LFEGLKPSAPLSWGWFGTVRvdRRVARGEEQQRLLL.......................................YHTHLRPRPRAYYL....EP..LPLPPEDEEPPA.PTLLEPEKKAPEPPKTDKPGAAPpsteerkkkstkGKK.RS
 1735- 1832 (129.09/56.12)	QPATKT.EDYGM.GPGR................................................S....GPYGVTvPP..D...........LLH..HPN.P......GSI..........................................................THLNYRQGSIGLytqnQP..LPAGGPRVDPYR.PVRL.PMQKLPTRP..TYPGVLP.....ttmtgvmGLE.PS
 1833- 1948 (147.97/65.45)	SYKTSVyRQQQPaVPQGQR..........LRQQLQAK.IQSQG..MLGQSSVHQmtpssSYGLQ......TSQGYT.PY..V...........SHVGL.........................QQ............................................HTG....PAGTMV....PPsySSQPYQSTHPSTnPTLVDPTRHLQQRPSGYVHQQAP..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.94|      77|     596|      13|      96|       4
---------------------------------------------------------------------------
   13-   96 (113.57/96.90)	PLKRPRlGPPDVYPQDPKQKEDELTAlNVKQgfnNQPAVSGD.EHGSAKNVSFNPAKiSSNFsSIIAEKLRCNTLPDTGRRKPQV
  613-  690 (136.38/87.78)	PGPRPP.SPFDDPADDPEHKEAEGSS.SSKL...EDPGLSESmDIDPSSSVLFEDME.KPDF.SLFSPTMPCEGKGSPSPEKPDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.11|      45|     233|     331|     377|       6
---------------------------------------------------------------------------
  331-  377 (82.14/53.17)	TPAPQ..PPTSSTPSTPFSD..LLMCPQHRPLVFglSCILQTILLCCPSAL
  560-  608 (73.97/41.91)	TQAPMltDPRSESERVEFFNlvLLFCELIRHDVF..SHNMYTCTLISRGDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      18|     159|     998|    1024|      14
---------------------------------------------------------------------------
  998- 1024 (23.33/36.60)	GARF.FLRA.FVLfprvNDiailcAELTG
 1159- 1178 (24.88/13.27)	GAVFaVLKAvFVL....GD.....AELKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.46|      22|     159|     896|     921|      15
---------------------------------------------------------------------------
  896-  921 (29.83/40.60)	SDLvgSYTTSLClCIVAVLRHYHaCL
 1061- 1082 (39.62/30.14)	SDL..SFHDSLA.TFVAILIARQ.CL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17213 with Med12 domain of Kingdom Metazoa
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