<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17207

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHPMNALQSLTGGPAAGAAGIGIPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMTVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQQQLQQQQQQQHLIKLHHQNQQQVPGPLFLLLASLLQCEPWAGSSHDPSMQQPQPPPAQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMSQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPALPGPRPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length737
PositionTail
OrganismNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae> Nomascus.
Aromaticity0.04
Grand average of hydropathy-0.601
Instability index80.25
Isoelectric point9.36
Molecular weight80956.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17207
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      18|      23|     392|     413|       2
---------------------------------------------------------------------------
  272-  295 (23.31/ 7.71)	HQPPPQPQQPP.vaqnQP.SQLpPqS
  403-  427 (24.07/ 7.33)	MPPPPQPSPQPgqpgsQPnSNVrP.A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.06|      18|      23|     170|     188|       3
---------------------------------------------------------------------------
  170-  188 (32.84/11.15)	QQQQQQQQFQAQQsAMQQQ
  194-  209 (32.81/ 8.20)	QQQQQQQQLQQQQ...QQQ
  245-  262 (31.41/ 7.50)	DPSMQQPQPPPAQ.ALPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     258.44|      60|     138|     298|     358|       4
---------------------------------------------------------------------------
  298-  350 (88.48/33.05)	.........Q.P.....LVSQA...QA..........LPGQML........YTQ.P.............................................PLKFVRAPMVVQQPP...V....QPQVQQQTAVQTAQAAQM
  351-  402 (47.88/17.04)	VAPGvQMItE.A.....L........A..........QGGMHI........RARfP.............................................PTTAVSA...VPSSS...IplgrQPMSQ....VQTPQS...
  414-  453 (38.09/ 9.71)	GQPG.......................sqpnsnvrpaLPGPRP........SPQ.P.............................................S...........QSP...V....TARTPQNFSVP.......
  454-  575 (47.02/13.88)	.SPG.PLN.T.PvnpssVMSPAgssQA..........EEQQYLdklkqlskYIE.PlrrminkidknedrkkdlskmkslldiltdpskrcplktlqkceiALEKLKNDMAVPTPPpppV....PPT.KQQYLCQPLLDAVL
  576-  607 (36.98/ 9.20)	AN.....I.RsP.....VFNHS....................L........YRT..................................................FVPAMTAIHGPP...I....TAPV..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.46|      20|      21|      71|      90|       5
---------------------------------------------------------------------------
   71-   90 (37.59/18.72)	PMNALQSLTGGPAAGAAGIG
   93-  110 (35.35/17.13)	PRGPGQSLGGMGSLGA..MG
  112-  126 (27.52/11.61)	PM....SLSGQPPPGTSGM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.78|      18|     443|     210|     228|       6
---------------------------------------------------------------------------
  210-  228 (30.95/18.58)	HLI.KLHHQNQQQVPgPLFL
  654-  672 (28.82/12.53)	HLIcKLDDKDLPSVP.PLEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17207 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQSLTGGPAAGAAGIGIPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMTVVSTAT
2) PWAGSSHDPSMQQPQPPPAQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
3) RAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMSQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPALPGPRPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
74
238
322
138
309
487










Molecular Recognition Features






MoRF SequenceStartStop




1) MHIRARF
367
373