<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17206

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGIPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMTVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQQQLQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQLQPQPPIQQPSMQQPQPPPAQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length746
PositionTail
OrganismNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae> Nomascus.
Aromaticity0.03
Grand average of hydropathy-0.741
Instability index88.81
Isoelectric point9.38
Molecular weight82376.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17206
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.72|      16|      21|     161|     181|       1
---------------------------------------------------------------------------
  170-  188 (30.32/ 7.00)	QQQQQaalQQQQ..QQQQQQF
  248-  265 (29.40/ 7.22)	QQQQQ...QQQQqqQQQQLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     190.70|      41|      41|     319|     359|       3
---------------------------------------------------------------------------
  290-  342 (46.21/ 9.70)	..QQ.MHHP...qhhqpppqpqqppvaqNQPSqLPPQSQTQPLVSQAQALPGQML........YTQP
  343-  376 (49.57/11.15)	PLKF.VRAPMVV................QQPP.VQPQVQQQTAVQTAQA..AQM.............
  396-  423 (52.26/12.32)	PGQQ.VQTP...................QSMP.PPPQPSPQP..GQ....PGS............QP
  456-  503 (42.66/ 8.15)	PQNFsVPSPGPL.................NTP.VNPSSVMSP.AGSSQAEEQQYLdklkqlskYIEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.25|      21|      21|      88|     108|       6
---------------------------------------------------------------------------
   81-   98 (21.82/ 8.67)	....PMNALQsLTGGPAAGAAG
   99-  120 (37.31/21.08)	IGIPPRGPGQsLGGMGSLGAMG
  126-  137 (19.12/ 6.50)	SGQPP..PG...TSGMA.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.80|      34|     151|     506|     540|       8
---------------------------------------------------------------------------
  506-  540 (53.74/31.83)	RMINKIDKNEDrKKDLSKMKSL.LDILTDPSKRCPL
  542-  568 (43.60/20.89)	TL....QKCEI...ALEKLKND.MAVPTPPPPPVP.
  664-  693 (42.46/20.12)	.LICKLD.....DKDLPSVPPLeLSVPADYPAQSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.03|      17|      49|     377|     395|      10
---------------------------------------------------------------------------
  377-  395 (25.61/16.34)	VAPGVQVSQSSLpmLSSPS
  427-  443 (33.42/15.03)	VSSGPAPSPSSF..LPSPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17206 with Med15 domain of Kingdom Metazoa
Unable to open file!