<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17195

Description Mediator of RNA polymerase II transcription subunit 13
SequenceRFQVHSTCHCNPEDGADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYTASSGGLCEEATAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDADSANQRLVMSAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSVKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGPAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYECLGENRKQVIKFPTCFYSLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESTNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2123
PositionMiddle
OrganismNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae> Nomascus.
Aromaticity0.08
Grand average of hydropathy-0.412
Instability index53.92
Isoelectric point5.38
Molecular weight233961.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17195
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     527.99|     147|     421|    1332|    1512|       1
---------------------------------------------------------------------------
  749-  833 (66.72/17.49)	.......................................................................................APRPTSHARPPST...SliyDSDLAVSYTDLDNLFNSDEDELT......PG.......SKKSANGSDDKASCKESKTGNLDplSCISTADLhkmyptpPSL.....
  890- 1063 (225.38/90.58)	KDFSY.VYKPENCQILVGCSMFapLKTLPSQYlppiklpeECIYRQSWTVGKLE..LLSSGP...AMPFikegDGSNMDQeygPAYTPQTHTSFGMPPSSappS...NSGAGILPSPSTPRFPTPRTPRTprtprgAGGPASAqgSVKYENSDLYSPASTPSTCRPLN..S.VEPATV.......PSIPEAHS
 1360- 1512 (235.89/142.08)	RDIAYvVLCPENEALLNGAKSF..FRDLTAIY........ECLGENRKQVIKFPtcFYSLGPylaSLPL....DSSLLSQ...PNLVAPTSQSLITPPQM...T...NTGNANTPSATLASAASSTMTMT......SGVAIST..SVATANSTLTTASTSSSSSSNLN..SGVSSNKL.......PSFPPFGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.84|      29|     712|     851|     879|       2
---------------------------------------------------------------------------
  851-  879 (51.39/34.00)	GSMDTTPGGTV.................LEGNSSSIGAQFKIEVDE
 1519- 1563 (38.19/22.89)	GSM.STQANTVqsgqlggqqtsalqtagISGESSSLPTQPHPDVSE
 1564- 1582 (23.26/10.32)	STMDRDKVGIP.................TDGDSHAI..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.84|      22|     674|     613|     643|       3
---------------------------------------------------------------------------
  311-  332 (39.27/14.76)	PAMSSVTLTPPTSPEEVQTVDP
  614-  635 (40.57/29.87)	PKKKDVEFLPPQLPSDKFKDDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.24|      55|     462|     693|     748|       6
---------------------------------------------------------------------------
  693-  748 (88.92/84.51)	FVEgDEEFLFPDKKD.......RQNSEREAGKKH.....KVEDGTSSVTVLSHEEDAMSLFSP..SVKQD
 1134- 1202 (74.32/63.36)	FLE.DELDIIGRNTDcgkeaekRFEALRATSAEHvngglKESEKLSDDLILLLQDQCTNLFSPfgAADQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.12|      18|     203|     226|     248|       7
---------------------------------------------------------------------------
  226-  248 (28.62/30.82)	IGEWKQFYPiscclKEMSEEKQE
  439-  456 (32.50/19.49)	LGQQQQILP.....KHKTNEKQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     505.77|     162|    1682|      34|     213|       9
---------------------------------------------------------------------------
   34-  213 (268.69/176.41)	AP..ILFPVTEEDPILS.SFSRC.LKADVLGV...WRRDQRpgrrelWIF.....WWGE..DPNFADL.IHHDLSEEEDGVWENGLS..YE.CRTLLfkAVHNLLERCLMNRnFVRIGK.....WFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPvyllsEEHITLAQQSNSPFQVilcpFGLNGTLTGQ
 1710- 1894 (237.08/124.21)	APpfILAPVKDKQTELGeTFGEAgQKYNVLFVgycLSHDQR......WILasctdLYGEllETCIINIdVPNRARRKKSSARKFGLQklWEwCLGLV..QMSSLPWRVVIGR.LGRIGHgelkdWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEP.....QGSFVIMPDSVSTGSV....FGRSTTLNMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.43|      31|     751|     505|     556|      10
---------------------------------------------------------------------------
  461-  492 (51.41/46.48)	PQKRPLTPfHHRVSVSDDVGMDADS.ANQRLV.M
  524-  556 (52.02/29.12)	PQPPPLSP.HPCDVVDEGVTKTPSTpQSQHFYqM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17195 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDADSANQRLVMSAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPP
2) DLDNLFNSDEDELTPGSKKSANGSDDKASCKE
3) GPAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
4) GSPVHSPGSHYPHGGDAGKGQSTDRLLSTEPHE
5) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
419
775
947
1970
1480
581
806
1032
2002
1578










Molecular Recognition Features






MoRF SequenceStartStop




NANANA