<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17180

Description Mediator of RNA polymerase II transcription subunit 13
SequenceGGAGASMPSLSAPPSKNLHVSKKYFKSFFLFGCPFYWFFFFLFSFFFSVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQVSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPHMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGVSTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYSAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2155
PositionMiddle
OrganismNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae> Nomascus.
Aromaticity0.08
Grand average of hydropathy-0.384
Instability index58.38
Isoelectric point5.81
Molecular weight236590.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17180
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     464.80|     110|     113|     383|     495|       1
---------------------------------------------------------------------------
  383-  470 (129.40/57.23)	.........................................PnRP.......PTIS.QPGFSAGPSSSSSLPPPASSKHKTTERQEK.....GDKLQKRPLIPFHHRPS.VAEELCMEQD..T.PGQKLGLAGIDSSLEV.SSSRKY
  471-  578 (150.19/66.62)	DKQMAVPSRNTSKQMNL.............NPMDSPhspisP.LP.......PTLSpQP...RG.QETESLDPPSVPVNPAL....Y.....GNGLELQQLSTLDDRTVlVGQRLPLMAE..V.SETAL.YCGIRPSNPE.SSEKWW
  602-  726 (128.78/54.20)	DAKMEVNSESTALQRLLaqpnkrfkiwqdkQPHMQP.........lhfldplPLSQ.QPGDSLGEVNDPYTFEDGDIKYIFTANKKC.....KQGTEKDSL.....KKN.KSEDGFGTKDvtT.PGHSTPVPDGKNAMSIfSSATKT
 1522- 1586 (56.43/18.74)	......................................................SS.ASGSSVPPVS.SSASAPGISQISTTSSSGFsgsvgGQNPSTGGVST..DRT..QGNIGCG.GD..TdPGQS...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.99|      74|    1266|     101|     180|       2
---------------------------------------------------------------------------
  101-  180 (115.18/91.24)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1370- 1446 (124.81/77.17)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2013|    2040|       3
---------------------------------------------------------------------------
 2013- 2040 (37.05/29.83)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2043- 2071 (44.88/25.98)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.86|      19|     910|     326|     345|       4
---------------------------------------------------------------------------
  326-  345 (31.77/23.56)	WKECiLNRTQSKRSQVSTPT
 1217- 1235 (38.09/23.80)	WTEC.FNALEQGRQYVDNPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     301.76|      57|      69|     919|     975|       5
---------------------------------------------------------------------------
  810-  853 (52.97/21.52)	..FPTP.PSLEQHPaFSPVMNY.KDGISS.ETVTALG...MMESPMVSMVST.......
  858-  903 (67.12/29.37)	....FK.MEVEDGL.GSPKPEEIKD.FSYVHKVPSF.QP.FVGS.SMFAPLKM...LPS
  919-  975 (98.73/46.92)	PSWAIP.PKIEQLP.MPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPA
  989- 1043 (82.94/38.16)	PRFSVPtPRTPRTP.RTPRGGGTASGQGSV.KYDSTDQGSPASTPSTTRP..LNSVEPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      28|    1964|    1986|       6
---------------------------------------------------------------------------
 1964- 1986 (25.52/23.56)	SPNNDdmfvDLPFPDDmDNDIGI
 1995- 2012 (34.86/15.93)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.10|      23|      27|    1685|    1711|       7
---------------------------------------------------------------------------
 1689- 1711 (43.93/35.15)	IQYLKSM..AFSVYCQCR...RPLPTQI
 1713- 1740 (29.17/11.36)	IKSLTGFgpAASIEMTLKnpeRPSPIQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.00|      13|      16|    1177|    1190|       9
---------------------------------------------------------------------------
 1177- 1190 (19.45/13.95)	QHTQPFASLSFlDY
 1194- 1206 (25.56/14.12)	NNRQTLPCVSW.SY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.76|      14|    1266|     348|     362|      10
---------------------------------------------------------------------------
  348-  362 (23.20/12.42)	EEPASNPATWDFvDP
 1496- 1509 (25.56/10.16)	NGSAAPPAGSAF.NP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.53|      27|     912|     182|     219|      11
---------------------------------------------------------------------------
  184-  210 (52.66/43.20)	WQYFYPMVLKKKEESKEEDE........LGYDDDF
 1304- 1338 (46.87/17.02)	WQQFHKMAGRGTYGSEESPEplpiptllVGYDKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.34|      12|      27|    1818|    1829|      12
---------------------------------------------------------------------------
 1818- 1829 (24.58/13.92)	KIGLQKLWEWCI
 1848- 1859 (22.75/12.35)	RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.08|      17|     136|    1644|    1661|      13
---------------------------------------------------------------------------
 1644- 1661 (26.88/24.25)	WLLSLMRCyTEMLDNLPE
 1667- 1683 (31.20/21.65)	FILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17180 with Med13 domain of Kingdom Metazoa
Unable to open file!