<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17177
Description |
Mediator complex subunit 14 |
Sequence | MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLVVLSYRKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP |
Length | 1451 |
Position | Tail |
Organism | Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae>
Nomascus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.172 |
Instability index | 52.12 |
Isoelectric point | 8.97 |
Molecular weight | 160227.28 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP17177
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 283.59| 62| 64| 999| 1060| 1
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18- 47 (26.82/ 6.27) GGGSGG..PP..S...........................apaPPPPGAAVA.AAAAAAASP...................................
999- 1047 (85.54/36.60) ...........................................PPPQQQPFPKQPGTSGAYP..L.TSPPTSYHSTVN..QSPSMMHTQSPGNLHAA
1048- 1112 (102.56/45.39) SSPSGALRAP..SPA.......................sfvptPPPSSHGISIGPGASFASP..HgTLDPSSPYTMV....SPSGRAGNWPGS.PQV
1113- 1198 (68.67/27.89) SGPSPAARMPgmSPAnpslhspvpdashspragtssqtmptnmPPPRKLP...QRSWAASIPtiL.T......HSALNilLLPSPTPGLVPG.LAGS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 212.75| 64| 394| 373| 589| 3
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292- 356 (109.88/150.66) CLHSFCLSLQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTI
443- 512 (102.87/166.79) CGNSECLHIFVD.LHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 178.75| 66| 396| 807| 989| 4
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876- 983 (79.89/243.55) LNAINKLPTVPMLGLTQRTNTAYqCFSILPQSSTHIrlaFRNmyCIDI.......ycrsrgvvairdgayslfdnsklvegfyPAPGLKTFLNMFVdsnQDARRRSVneddnPPS
1275- 1375 (98.86/40.53) LQVLEKFFETRVAGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHImklelfpdqatqlkwnvqfcltippsappiappgtPAVVLKSKMLFFL...QLTQKTSV.....PPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.33| 10| 25| 1399| 1408| 16
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1399- 1408 (17.56/ 8.60) PRQQNSSVAA
1425- 1434 (19.77/10.56) PRQGECTIFA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.23| 16| 32| 79| 94| 19
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79- 94 (27.14/18.03) KIE....IVQFASRTRQLFV
108- 127 (21.09/12.38) KVEkcamISSFLDQQAILFV
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