<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17158

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length534
PositionUnknown
OrganismGorilla gorilla gorilla (Western lowland gorilla)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Gorilla.
Aromaticity0.04
Grand average of hydropathy-0.336
Instability index59.28
Isoelectric point9.40
Molecular weight55454.93
Publications
PubMed=22398555

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17158
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     209.99|      38|      40|     374|     411|       2
---------------------------------------------------------------------------
  140-  176 (55.08/10.41)	GSGLAPTA.Q...PGAPSMAGTVAPGGVSG.PSPAQLGAPAL
  347-  402 (69.06/15.12)	GGQQAPPGlG...PPQPQPQGTVGASGATGQPQPQGTAQPPP
  403-  428 (42.09/ 6.03)	GAPQGPPG.AasgPP...P............PGPILRPQNPG
  488-  522 (43.75/ 6.59)	.AQSWPAQ.L..pPRAPLP.GQMLLSGGPRGPVPQPGLQP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.02|      46|      74|     215|     268|       3
---------------------------------------------------------------------------
  215-  268 (66.42/65.45)	PCQVYVNHgeNLKTEQwpQKLIMQLIP.QQ..LLTTLGPLFRNSRMVQfhftNKDLE
  292-  340 (71.60/44.39)	PCEVRVLM..LLYSSK..KKIFMGLIPyDQsgFVNGIRQVITNHKQVQ....QQKLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.33|      18|     322|     113|     133|       4
---------------------------------------------------------------------------
  113-  133 (30.17/15.64)	PQL......PPgPPGAPKPPPASqpSL
  431-  454 (30.16/ 6.83)	PQLrslllnPP.PPQTGVPPPQA..SL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.26|      42|      53|       4|      52|       5
---------------------------------------------------------------------------
    4-   52 (67.66/46.63)	GSEGPAR..AGSVVADvvFVIEGTAN....LGPYFEGLRkhyllPAIEYFNG.GPP
   58-  106 (62.60/29.65)	GGDVPGNlsAAQVAAQ..NAVEAAKNqkagLGPRFSPIT.....PLQQAAPGvGPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17158 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
2) PPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
331
51
532
177










Molecular Recognition Features






MoRF SequenceStartStop




NANANA