<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17125

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDNQGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQVRHAHLGPSWGPDLVLLSWRGSQHVPGGRAVPQSGALRPPPSLSTGRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACMTSRASEEAPAFVQLGPSLDRLHPEDRP
Length847
PositionTail
OrganismGorilla gorilla gorilla (Western lowland gorilla)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Gorilla.
Aromaticity0.06
Grand average of hydropathy-0.040
Instability index51.47
Isoelectric point7.09
Molecular weight93072.59
Publications
PubMed=22398555

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP17125
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     575.58|     138|     368|     337|     474|       1
---------------------------------------------------------------------------
  337-  474 (227.16/128.25)	LKWRILSATNDLDRVSAVALP...............................KLPIS.L....TNTDLKVAS.D.TQFYPGLGLALAFHD.GSVHIVHRLSLQTMA..VFYSSAA.PRPVDEPAMKRPRTAGPAVHLKAMQLSW.TSLALVGIDNQGKLSVLRLSPSMGHP..LEVGLALRHL
  522-  687 (151.01/82.63)	LSTRILAMKASLCKLSPCTVTrvcdyhtklfliaisstlksllrphflntpdKSPGDrL....TEICTKITDvDiDKVMINLKTEEFVLDmNTLQALQQL.LQWVGdfVLYLLASlPNQV......RHAHLGPSWGPDLVLLSWrGSQHVPGGRAVPQSGALRPPPSLSTG..RDEGPA....
  710-  841 (197.41/110.43)	LDW..LPASDGL..VSRLQ.P...............................KQPLR.LqfgrAPTLPGSAA.T.LQLD...GLARAPGQ.PKIDHLRRLHLGACP..TEECKAC.TRCGCVTMLKSPNRTT.AV..KQWEQRW.IKNCL.AVEGRGPDACMTSRASEEAPafVQLGPSLDRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     313.68|      99|     200|       1|     129|       2
---------------------------------------------------------------------------
   22-  129 (163.85/158.50)	EKWSKSTHCPSVPLACAWSCRNLIAFTMD.......LRSDDQDLTrmihilDTEhPwDLHSIPSEHREAITCLEW...DQSGSRLL..SADADGQIKCWSM.ADHL.ANSWESSVGSLVeGD
  157-  233 (96.05/47.92)	EKFSRVKFSPSLTLFGGKPMEGWIAVTVSglvtvslLKPSGQVLT......STE.S..LCRLRG..RVALADIAF....TGGGNIV..VATADG............................
  270-  331 (53.78/20.32)	.........................................................DLNR..KDKFPAITHLKFlarDMSEQVLLcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVV.GD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17125 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA