<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17103

Description Mediator complex subunit 23
SequenceMVQMETQLQSIFEDVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRPHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCGMNAREENPWIPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGEDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSESEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAINSGSPAPQSNQVPVSLPVTQ
Length1377
PositionTail
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.10
Grand average of hydropathy-0.006
Instability index45.70
Isoelectric point6.93
Molecular weight157357.19
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17103
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.58|      26|      89|    1074|    1101|       1
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 1074- 1101 (47.35/36.78)	DSYYCRLIGRLVDTMAgkSPGPFPNCDW
 1167- 1192 (47.24/29.88)	EPYWIVLHDRIVSVIS..SPSLTSESEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      30|     348|     357|       2
---------------------------------------------------------------------------
  348-  357 (18.69/ 9.19)	IFFVLFQFAS
  381-  390 (19.45/ 9.85)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.91|      47|     619|     496|     544|       3
---------------------------------------------------------------------------
  496-  544 (73.48/57.20)	CFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLpMNLLdSLTVHA
 1118- 1164 (78.42/50.83)	CVELMALAVSGEDVGNALLNVVLKSQPLVPRENITAW.MNAI.GLIITA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.73|      28|      43|     610|     638|       4
---------------------------------------------------------------------------
  610-  638 (48.25/33.81)	LHTLLEMFSYRM......HHIQPHYrVQLLSHLHT
  650-  683 (42.48/24.72)	LHLCVESTALRLitalgsSEVQPQF.TRFLSDPKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.41|      47|      49|     203|     251|       7
---------------------------------------------------------------------------
  151-  197 (51.23/28.92)	.IPNTVSSAVVQQLL.AARevIAYILERnaC.LLPAY...FAVTEIRKLYPEG.
  203-  251 (77.08/56.04)	LLGNLVSDFVDTFRP.TAR..INSICGR..CsLLPVVnNSGAICNSWKLDPATL
  255-  297 (66.10/39.47)	LKGLLPYD.KDLFEPqTAL..LRYVLEQ......PY..SRDMVCNMLGLNKQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.29|      51|     717|      25|      92|       9
---------------------------------------------------------------------------
   32-   92 (83.44/87.29)	TPEDEKTKLISCL.GAFRQF........................WGGLSQESHeqciqwIVKFIHGQHSPKrisfLYDCL..AMAVET
  732-  809 (76.85/42.23)	TPHNWASHTLSCFpGPLQAFfkqnnvpqesrfnlkknveeeyrkWKSMTNEND......IITHFSMQGSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.45|      46|     257|     980|    1025|      12
---------------------------------------------------------------------------
  980- 1025 (84.36/58.93)	IHRFLE..LLPVSKSLETLL..DHLGGLY..KFHDRPVTYLYN.TLHYYEMHL
 1236- 1288 (65.09/43.57)	IPKFLTevLLPIVKTEFQLLyvYHLVGPFlqRFQQERTRCMIEiGVAFYDMLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.48|      40|     372|     925|     973|      13
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  925-  973 (67.95/54.40)	DWHTKHMN.........YHKKYpeklYFEG..LAEQVDPPVQIQSPYLPIYfgnvcLRFL
 1291- 1341 (62.53/32.24)	DQCSAHLNymdpicdflYHMKY....MFTGdsVKEQVEKIICNLKPALKLR.....LRFI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17103 with Med23 domain of Kingdom Metazoa
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