<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17099

Description Cyclin dependent kinase 19
SequenceMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPAAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLAPSGANSGGPVMPADYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPTHQGHRY
Length398
PositionKinase
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.08
Grand average of hydropathy-0.731
Instability index61.03
Isoelectric point8.68
Molecular weight44791.02
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17099
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.55|      21|      32|     307|     328|       1
---------------------------------------------------------------------------
  307-  328 (34.46/20.69)	GAGAGAGGAGAGLQHSQdSGLN
  342-  362 (41.09/20.84)	GANSGGPVMPADYQHSS.SRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      14|      17|     363|     376|       5
---------------------------------------------------------------------------
  363-  376 (25.22/13.79)	YQSSVQGSSQSQST
  379-  392 (27.04/15.25)	YSSSSQQSAQYHPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      16|      17|     215|     230|       6
---------------------------------------------------------------------------
  215-  230 (28.65/17.20)	DPTKRITSEQALQDPY
  234-  249 (30.88/19.05)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17099 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPAAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLAPSGANSGGPVMPADYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPTHQGHRY
249
398










Molecular Recognition Features






MoRF SequenceStartStop




1) NKKPRLAP
2) QYHPTHQGHRY
333
388
340
398