<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17096

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMKTTYARHRDRAGVEETMENFSALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGTAPQPTSATAPPGADKSAAGCGPFYLMRELPGSTELTGSTNLITHYNLEHSYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGVGSSQASSSSSLR
Length261
PositionHead
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.05
Grand average of hydropathy-1.065
Instability index62.61
Isoelectric point9.84
Molecular weight28295.91
Publications
PubMed=17975172

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP17096
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.67|      16|      16|     207|     222|       2
---------------------------------------------------------------------------
  189-  210 (22.18/ 8.12)	KKKNKHKHKQSRtqdpvpPETP
  211-  229 (20.31/ 6.90)	SDSDHKKKKKKK...eedPERK
  230-  247 (24.18/ 9.43)	RKKKEKKKKKNR....hsPDHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.26|      26|      46|     106|     135|       5
---------------------------------------------------------------------------
   85-  125 (34.40/28.79)	MRELPGSTEL.......tgstnlithynLEHSYNKFCGkkvkEKLSNF
  126-  169 (37.86/22.29)	LPDLPGMIDLpgshdnsslrsliekppiLGGSFNPITG....TMLAGF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17096 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPIT
2) MKTTYARHRDRAGVEETMENFSALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGTAPQPTSATAPPGADKSA
3) TMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGVGSSQASSSSSLR
125
1
164
162
76
261










Molecular Recognition Features






MoRF SequenceStartStop




1) DRAGVEETMENFSALFG
2) DSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPD
10
212
26
245