<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP17094

Description Mediator complex subunit 25
SequenceMEVEPTSPACPAQTWPRARPAAQLRRPAPAHAQRRRTSAPPAEAAAAAAVAAVAAAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGETCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQASLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length805
PositionUnknown
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.05
Grand average of hydropathy-0.248
Instability index61.70
Isoelectric point9.07
Molecular weight84007.50
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP17094
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.71|      23|      23|     655|     677|       3
---------------------------------------------------------------------------
  650-  677 (40.35/ 7.60)	GASAASGQPQPQGAAQAPPGAPQ
  750-  772 (40.36/ 7.61)	GPPLLHPPPAQSWPAQLPPRAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.97|      17|      49|     679|     696|       4
---------------------------------------------------------------------------
  678-  695 (33.17/12.53)	GPPgAAPGPPPPGPILRP
  711-  727 (28.80/ 6.02)	PPP.PQTGVPPPQASLHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     340.59|     101|     297|     132|     288|       6
---------------------------------------------------------------------------
   71-  128 (57.03/ 9.17)	...GGLVADVVFVIEGTANLGPYFEGLRKH............................Y....LLPAIEyfnggppaETDFGGdY.........G..GTQYSLV.........................................
  161-  269 (171.45/125.74)	KFMGGGGETCSLIAEGLSTALQLFDDFKKMreqigqtH.........RVCLLICNSPPY....LLPAVE........STTYSG.YTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPAmLEP..............LQPP
  547-  646 (112.11/31.54)	RIMGNGFAGCV..........................HfphtapcevRVLMLLYSSKKKifmgLIP..................YDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPG.LGPiledqarpsqnllqLRPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.82|      20|     285|     432|     451|       7
---------------------------------------------------------------------------
  389-  402 (32.03/ 7.85)	PGPPGAPKP....PPA...SQ
  432-  451 (40.30/12.05)	PGGVSGPSPAQLGAPALG.GQ
  730-  746 (30.49/ 7.07)	P..PGA..PALLPPPHQGlGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.59|      22|      23|      21|      42|       8
---------------------------------------------------------------------------
   21-   42 (40.10/20.51)	AAQLRRPAPAHAQRRRT..SAPPA
   45-   68 (30.49/13.73)	AAAAAVAAVAAAARGMVpgSEGPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP17094 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQASLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
3) MEVEPTSPACPAQTWPRARPAAQLRRPAPAHAQRRRTSAPP
291
603
1
449
803
41










Molecular Recognition Features






MoRF SequenceStartStop




1) AAVAA
2) AQTWPRARPAAQLRRPAPAHAQR
48
12
52
34